Abstract:This prospective observational study was carried out to evaluate the efficacy of large loop excision of the transformation zone (LLETZ) as a management strategy for women with four or more smears showing borderline changes or mild dyskaryosis. A total of 102 women with four or more smears showing minor abnormalities and no colposcopic evidence of high-grade disease opted to undergo LLETZ in preference to continued cytological surveillance. Histology of the LLETZ specimens showed 11 cases of CIN2/3, one CGIN, 3… Show more
“…One study [23] that excised the cervical tissue of 102 women following >4 borderline or mildly abnormal smears and no colposcopic evidence of high-grade disease found only 11 cases (11%) of undiagnosed CIN2/3. Thus, although immediate excision provides the greatest safety, almost 90% of women would be overtreated.…”
Women with long-term persistence of HPV infection appear to be generally more susceptible to other HPV infections, especially longer-lasting infections, than are women who cleared their HPV infections.
“…One study [23] that excised the cervical tissue of 102 women following >4 borderline or mildly abnormal smears and no colposcopic evidence of high-grade disease found only 11 cases (11%) of undiagnosed CIN2/3. Thus, although immediate excision provides the greatest safety, almost 90% of women would be overtreated.…”
Women with long-term persistence of HPV infection appear to be generally more susceptible to other HPV infections, especially longer-lasting infections, than are women who cleared their HPV infections.
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