Persistent luminescence nanothermometers

López-Peña, Gabriel; Montes, Emilio Fontela; Lifante, G.; Solé, J. Garcı́a; Jaque, Daniel; Dı́az-Torres, L.A.; Salas, P.

doi:10.1063/1.4990873

Cited by 33 publications

(13 citation statements)

References 28 publications

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“…Fortunately, recent advances have produced probes with heat-sensitive luminescence that are efficient nanothermometers for monitoring temperature on the microscale 22–26 . Therefore, microscopic temperature changes can be read by measuring the luminescence intensity, which provides an applicable strategy for determining the temperature of the probe on the electrode in situ 27 .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous multi-signal quantification for highly precise serodiagnosis utilizing a rationally constructed platform

et al. 2019

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Serodiagnosis with a single quantification method suffers from high false positive/negative rates. In this study, a three-channel platform with an accessional instrumented system was constructed for simultaneous electrochemical, luminescent, and photothermal quantification of H2S, a bio-indicator for acute pancreatitis (AP) diagnosis. Utilizing the specific reaction between platform and H2S, the three-channel platform showed high sensitivity and selectivity in the biological H2S concentration range. The three-channel platform was also feasible for identifying the difference in the plasma H2S concentrations of AP and normal mice. More importantly, the precision of AP serodiagnosis was significantly improved (>99.0%) using the three-signal method based on the three-channel platform and an optimized threshold, which was clearly higher than that of the single- or two-signal methods (79.5%–94.1%). Our study highlights the importance of constructing a multichannel platform for the simultaneous multi-signal quantification of bio-indicators, and provides rigorous ways to improve the precision of medical serodiagnosis.

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Section: Introductionmentioning

confidence: 99%

Simultaneous multi-signal quantification for highly precise serodiagnosis utilizing a rationally constructed platform

et al. 2019

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“…9b). These NIR-emitting PLNPs lead to an improved contrast quality and deeper tissue penetration depth than the Cr 3+ -doped PLNPs with the emission in the first NIR window [116][117][118][119].…”

Section: In Vivo Pl Imaging In the Second Or Third Biological Windowmentioning

confidence: 99%

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

Ding

et al. 2020

Nano-Micro Lett.

130

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Persistent luminescence phosphors are a novel group of promising luminescent materials with afterglow properties after the stoppage of excitation. In the past decade, persistent luminescence nanoparticles (PLNPs) with intriguing optical properties have attracted a wide range of attention in various areas. Especially in recent years, the development and applications in biomedical fields have been widely explored. Owing to the efficient elimination of the autofluorescence interferences from biotissues and the ultra-long near-infrared afterglow emission, many researches have focused on the manipulation of PLNPs in biosensing, cell tracking, bioimaging and cancer therapy. These achievements stimulated the growing interest in designing new types of PLNPs with desired superior characteristics and multiple functions. In this review, we summarize the works on synthesis methods, bioapplications, biomembrane modification and biosafety of PLNPs and highlight the recent advances in biosensing, imaging and imaging-guided therapy. We further discuss the new types of PLNPs as a newly emerged class of functional biomaterials for multiple applications. Finally, the remaining problems and challenges are discussed with suggestions and prospects for potential future directions in the biomedical applications.

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“…Biodetection is one of the most essential technologies in bioanalysis, 55 including the detection of various biological indicators such as proteins, [56][57][58] nucleic acids, 2,59 biological small molecules, 15,60,61 and physiological parameters. 23,62 These technologies have already played important roles in disease diagnosis, [18][19][20] water quality monitoring, 63 food and drug safety survey, 6 and criminal investigations. 65,66 Among various biodetection technologies, uorophotometry provides a convenient, 67,68 real-time, [69][70][71][72] and non-invasive [73][74][75] method for detecting analyte contents, and is one of the most promising quantitative detection technologies.…”

Section: Application Of Vplnps In Biomedicinementioning

confidence: 99%

“…21,22 Beneting from this unique feature, PLNPs have already received much attention in bioanalysis in recent decades. 23,24 However, the excitation band of conventional PLNPs is usually located in the ultraviolet (UV) region. 25,26 tissue damage and has low tissue penetration.…”

Section: Introductionmentioning

confidence: 99%