Persistent infection of <i>Helicobacter pylori</i> affects weight loss in obese population compared with persistent negative: A case‐control study based on healthy Chinese

Zhang, Jinshun; Chen, Yahong; Chen, Weiling; Xu, Hongfang; Wang, Huihong; Chen, Lijuan; Ye, Yafei; Wang, Zhongtai; Ye, Juanjuan

doi:10.1111/hel.12697

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…The associations among obesity, genetics of obesity, obesity related bacteria and H. pylori infection were reported pair wisely, but their causal relationships are still largely unknown. It is reported that H. pylori persistent infection had a negative effect on the fall of BMI values in Chinese obese population 45 . This comorbidity between H. pylori infection and obesity may be caused by the pleiotropic effects of FTO and other genes.…”

Section: Discussionmentioning

confidence: 97%

Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

Wang

et al. 2021

Sci Rep

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Helicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H. pylori infection conducted in Chinese population, who carried different and relatively homogenous strain of H. pylori. In this work, we performed SNP (single nucleotide polymorphism)-based, gene-based and pathway-based genome-wide association analyses to investigate the genetic basis of host susceptibility to H. pylori infection in 480 Chinese individuals. We also profiled the composition and function of the gut microbiota between H. pylori infection cases and controls. We found several genes and pathways associated with H. pylori infection (P < 0.05), replicated one previously reported SNP rs10004195 in TLR1 gene region (P = 0.02). We also found that glycosaminoglycan biosynthesis related pathway was associated with both onset and progression of H. pylori infection. In the gut microbiome association study, we identified 2 species, 3 genera and several pathways had differential abundance between H. pylori infected cases and controls. This paper is the first GWAS for H. pylori infection in Chinese population, and we combined the genetic and microbial data to comprehensively discuss the basis of host susceptibility to H. pylori infection.

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Section: Discussionmentioning

confidence: 97%

Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

Wang

et al. 2021

Sci Rep

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“…It was inferred that the difference in prevalence rates between men and women may be affected by a variety of factors, such as different opportunity to obtain antibiotics, or stronger estrogens related immune response against infection in women, or different living habits 57 . Some studies also showed that H. pylori infection is positively correlated with higher body mass index (BMI) 57–59 . A community‐based study showed that H. pylori infection independently increased the risk of obesity (BMI ≥ 30) (adjusted OR: 1.84; 95% CI: 1.08–3.13) in Taiwanese adults under 50 years old 60 …”

Section: Discussionmentioning

confidence: 99%

Declining trends of prevalence ofHelicobacter pyloriinfection and incidence of gastric cancer in Taiwan: An updated cross‐sectional survey and meta‐analysis

et al. 2022

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Background We aimed to assess the latest prevalence and secular trend of Helicobacter pylori infection and its association with the incidence and mortality of gastric cancer in Taiwan. Materials and Methods Adults naive to H. pylori eradication received 13C‐urea breath test (13C‐UBT), H. pylori stool antigen test, and serology test during 2019–2020 in this prospective screening program. Children and adolescent aged between 7 and 19 years received 13C‐UBT for H. pylori screening. We also conducted a systematic review and meta‐analysis to assess the secular trend of prevalence of H. pylori from 1990 to 2020 in Taiwan. The secular trends of age‐standardized incidence and mortality of gastric cancer were obtained from the Taiwan Cancer Registry. Results A total of 1494 participants were enrolled, including 294 children or adolescents and 1200 adults. The overall prevalence of active H. pylori infection by 13C‐UBT was 26.6% (397/1494), which was 30.8% in adults and 9.5% in adolescents/children. The age‐standardized prevalence of active H. pylori infection was 32.3% in adults after adjustment of the population structure in Taiwan. Of the 29 studies including 38,597 subjects eligible for the meta‐analysis, the pooled prevalence of H. pylori infection decreased from 63.8% (95% CI: 55.9%–71%) in 1990–2000 to 28.2% (95% CI:21.8%–35.6%) in 2016–2020. The age‐standardized incidence and mortality of gastric cancer have also declined from 15.2 to 10.75 per 100,000, respectively, in 1999 to 9.29 and 5.4 per 100,000, respectively, in 2019. Conclusions The prevalence of H. pylori infection has declined in Taiwan, which correlates with the declining trends of age‐standardized incidence and mortality of gastric cancer in Taiwan.

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“…The stone burden was calculated by the formula (0.785 × length max × width max ) introduced by the Clinical Research Office of the Endourological Society [ 8 ]. According to the standard set by the World Health Organization, a body mass index (BMI) of ≥ 28 is considered an obese patient in the Chinese population [ 9 ]. The present study was approved by the Ethics Committee of the First Affiliated Hospital of University of South China (No.202008191), in accordance with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

The safety and efficiency of a 1470 nm laser in obtaining tract hemostasis in tubeless percutaneous nephrolithotomy: a retrospective cross-sectional study

Zhang

Fei

et al. 2022

BMC Urol

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Objective It is challenging to perform a tubeless percutaneous nephrolithotomy (PNL) in patients with tract bleeding. The present study was designed to study the safety and efficacy of the 1470 nm laser for hemostatic completion in tubeless PNL patients with tract bleeding. Patients and Methods Between January 2020 and October 2021, 120 patients were retrospectively included and divided into two groups. The hemostasis group included 60 patients receiving tubeless PNL, in which a 1470 nm laser was used to manage tract bleeding. The other group included 60 patients receiving tubeless PNL in which the hemostasis procedure was not performed, serving as the control group. The differences in the patients’ demographic characteristics, procedural information, and posttreatment outcomes between the two groups were statistically compared. Results The differences associated with sex, age, weight, body mass index, urine culture, stone burden, calyx of puncture, degree of hydronephrosis and comorbidities between the two groups were not statistically significant. Compared with the control group, the hemostasis group showed greatly reduced blood loss (0.61 ± 0.31 vs. 0.85 ± 0.46 g/dL) and decreased postoperative hospitalization duration (2.83 ± 0.81 vs. 4.45 ± 0.91 days). The differences in operative time, stone-free rate, Visual Analogue Score and postoperative complications between the two groups were not statistically significant. In the subgroup analysis, the obese patients and patients with moderate to severe hydronephrosis in the hemostasis group also showed a significantly less blood loss (0.51 ± 0.22 vs. 0.83 ± 0.48 g/dL; 0.54 ± 0.27 vs. 0.85 ± 0.47 g/dL, respectively) and shorter length of postoperative hospitalization (2.62 ± 0.51 vs. 4.47 ± 1.19 days; 2.97 ± 0.63 vs. 4.41 ± 0.91 days, respectively) than those in the control group. Conclusions Our results demonstrated that 1470 nm laser is a safe, feasible and effective method to obtain tract hemostasis in tubeless PNL.

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Persistent infection of Helicobacter pylori affects weight loss in obese population compared with persistent negative: A case‐control study based on healthy Chinese

Cited by 9 publications

References 16 publications

Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection

Declining trends of prevalence ofHelicobacter pyloriinfection and incidence of gastric cancer in Taiwan: An updated cross‐sectional survey and meta‐analysis

The safety and efficiency of a 1470 nm laser in obtaining tract hemostasis in tubeless percutaneous nephrolithotomy: a retrospective cross-sectional study

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