Persistent Idiopathic Facial Pain Responsive to Topiramate

Volcy, Michel; Rapoport, AM; Tepper, SJ; Sheftell, FD; Bigal, ME

doi:10.1111/j.1468-2982.2006.01036.x

Cited by 26 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therapeutic trials of PIFP (and AFP) have been reported as efficient, but the trials are not all randomized or controlled. Case series using tricyclic antidepressants (115), an open study on duloxetine (116), a randomized controlled trial on venlafaxine (117), and open studies on anticonvulsants (118,119) and low level laser (120) have all shown beneficial effects, but other than one study the level of evidence is clearly low. Similarly, based on the premise that PIFP is neuropathic, high-frequency repetitive transcranial magnetic stimulation (rTMS) on the right secondary somatosensory (S2) cortex in patients with neuropathic orofacial pain induced significant pain relief compared to stimulation of the sensorimotor (S1/M1) cortex and sham stimulation (121).…”

Section: Treatmentmentioning

confidence: 99%

Persistent idiopathic facial pain

Benoliel

Gaul

2017

Cephalalgia

View full text Add to dashboard Cite

Background Persistent idiopathic facial pain (PIFP) is a chronic disorder recurring daily for more than two hours per day over more than three months, in the absence of clinical neurological deficit. PIFP is the current terminology for Atypical Facial Pain and is characterized by daily or near daily pain that is initially confined but may subsequently spread. Pain cannot be attributed to any pathological process, although traumatic neuropathic mechanisms are suspected. When present intraorally, PIFP has been termed 'Atypical Odontalgia', and this entity is discussed in a separate article in this special issue. PIFP is often a difficult but important differential diagnosis among chronic facial pain syndromes. Aim To summarize current knowledge on diagnostic criteria, differential diagnosis, pathophysiology and management of PIFP. Methods We present a narrative review reporting current literature and personal experience. Additionally, we discuss and differentiate the common differential diagnoses associated with PIFP including traumatic trigeminal neuropathies, regional myofascial pain, atypical neurovascular pains and atypical trigeminal neuropathic pains. Results and conclusion The underlying pathophysiology in PIFP is still enigmatic, however neuropathic mechanisms may be relevant. PIFP needs interdisciplinary collaboration to rule out and manage secondary causes, psychiatric comorbidities and other facial pain syndromes, particularly trigeminal neuralgia. Burden of disease and psychiatric comorbidity screening is recommended at an early stage of disease, and should be addressed in the management plan. Future research is needed to establish clear diagnostic criteria and treatment strategies based on clinical findings and individual pathophysiology.

show abstract

Section: Treatmentmentioning

confidence: 99%

Persistent idiopathic facial pain

Benoliel

Gaul

2017

Cephalalgia

View full text Add to dashboard Cite

show abstract

“…These figures are probably an underestimation of the real incidence since not all such patients are evaluated in regional neurological services. Owing to obvious similarities, both disorders may previously have been regarded as persistent idiopathic facial pain . Besides, a considerable number of patients may be referred to ophthalmology and ENT services.…”

Section: Discussionmentioning

confidence: 99%

“…Owing to obvious similarities, both disorders may previously have been regarded as persistent idiopathic facial pain. 4,5 Besides, a considerable number of patients may be referred to ophthalmology and ENT services.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Ophthalmodynia and Idiopathic Rhinalgia: A Prospective Series of 16 New Cases

et al. 2015

View full text Add to dashboard Cite

show abstract

“…(72) A single case report suggested efficacy of topiramate in PIFP treatment. (73) Calcitonin did not show sufficient pain relief in a randomized controlled trial on PIFP. (74) Sumatriptan showed only a transient effect on pain score reduction but this effect was very small so that sumatriptan was not considered an appropriate therapeutic option for the treatment of PIFP in two randomized placebo-controlled clinical trials.…”

Section: Medical Treatment For Persistent Idiopathic Facial Painmentioning

confidence: 99%

Trigeminal neuralgia and persistent idiopathic facial pain

Obermann

Holle

Katsarava

2012

View full text Add to dashboard Cite

Trigeminal neuralgia (TN) and persistent idiopathic facial pain (PIFP) are two of the most puzzling orofacial pain conditions and affected patients often are very difficult to treat. TN is characterized by paroxysms of brief but crucial pain, followed by asymptomatic periods without pain. In some patients a constant dull background pain may persist. This constant dull pain sometimes makes the distinction from PIFP difficult. PIFP is defined as continuous facial pain, typically localized in a circumscribed area of the face, which is not accompanied by any neurological or other lesion identified by clinical examination or clinical investigations. The pain usually does not stay within the usual anatomic boundaries of the trigeminal nerve distribution and is a diagnosis of exclusion. Epidemiologic evidence on TN and even more so on PIFP is quite scarce, but generally both conditions are considered to be rare diseases. The aetiology and underlying pathophysiology of TN and more so PIFP remain unknown. Treatment is based on only few randomized controlled clinical trials and insufficiently evaluated surgical procedures.

show abstract

Persistent Idiopathic Facial Pain Responsive to Topiramate

Cited by 26 publications

References 31 publications

Persistent idiopathic facial pain

Persistent idiopathic facial pain

Idiopathic Ophthalmodynia and Idiopathic Rhinalgia: A Prospective Series of 16 New Cases

Trigeminal neuralgia and persistent idiopathic facial pain

Contact Info

Product

Resources

About