Persistent hyaloid artery with an aberrant peripheral retinal attachment: A unique presentation

Sheth, Jay; Sharma, Ashish; Chakraborty, Santonu

doi:10.4103/0974-620x.111924

Cited by 10 publications

(9 citation statements)

References 4 publications

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“…The HA, a branch of the ophthalmic artery, is located in the optic canal and extends from the optic disc to the crystalline lens through the vitreous humour [ 3 ]. HA branches throughout the vitreous, forming the vasa hyaloidea propria [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a healthy foetus, regression of the HA itself starts at 18 weeks, and by 29 gestational weeks it disappears leaving clear central zone in the vitreous humour, called Cloquet’s canal [ 3 , 5 , 16 ]. The main trunk of the HA finally closes centrally by the end of gestation [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Atrophy of the HA is usually complete before birth, but anatomical remnants of the hyaloid system may present as Mittendorf’s dot at the posterior lens capsule or Bergmeister’s papilla at the optic disc [ 2 , 3 ]. PHA is seen in 3% of full term infants and 95% of premature infants [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…PHA is seen in 3% of full term infants and 95% of premature infants [ 4 ]. However, PHA with active blood flow is a rare finding of unknown incidence [ 2 , 3 , 5 ], but when present may be supplying a part of the retinal tissue [ 3 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Central retinal artery and vein occlusion as a complication of persistent hyaloid artery – a case report

et al. 2020

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Background In this case report, we present for the first time central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO) as a complication of persistent hyaloid artery (PHA). Case presentation In August 2019, a six-year-old male patient manifested right eye (RE) excessive tearing, conjunctival injection and pain. On examination, RE demonstrated light perception and intraocular pressure of 36 mmHg. The diagnoses of neovascular glaucoma, CRVO and CRAO were established as affirmed with fluorescein angiography (FA). PHA was not reported. Extensive work-up and family history were unremarkable. The child was born on term after uncomplicated twin pregnancy. In December 2019, he was referred to our Centre. Transillumination revealed fully dilated, non-reactive RE pupil, clear lens and tubular remnant of HA containing blood cells in its lumen freely rotating in the anterior vitreous. Conclusions PHA results from failure of apoptosis during gestation. It can easily be observed during the red reflex screening at neonatal wards. We hypothesized that PHA twisting led to torsion of the residual primordial common bulb, branching off to HA and CRA with CRAO occurring first. The consequential CRVO presumably advanced by venous stasis due to decrease in arterial inflow. Liquid vitreous appears as early as 4 years of age enabling PHA to whirl more freely. Thus, in case of PHA, we advocate FA to be performed and if connection with retinal artery is proven, parents should be informed on the possible devastating complications and prompt surgical treatment should be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Central retinal artery and vein occlusion as a complication of persistent hyaloid artery – a case report

et al. 2020

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“…Several congenital deformities of the eye occur such as coloboma, congenital glaucoma, congenital cataracts, congenital detached retina, partially persistent iridopupillary membrane, persistent hyaloid artery, microphthalmia and Peter's anomaly, Leber's Congenital Ameurosis [151][152][153][154][155][156]. While the cause of most of these diseases is rooted deep in mutation of genes such as PAX2, PAX6, CYP1B1, GLC3A, GLC3B, GLC3C, FOXC1, CEP290, CRB1, GUCY2D, RPE65, several reports suggest autophagy may be compromised in some of these diseases [157].…”

Section: Autophagy In Congenital Ocular Abnormalitiesmentioning

confidence: 99%

Autophagy in Ocular Pathophysiology

Mitter¹,

Boulton²

2016

Autophagy in Current Trends in Cellular Physiology and Pathology

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Autophagy is an evolutionarily conserved intracellular recycling pathway that is indispensable for cellular quality control. Dysfunctional autophagy has been associated with several neurodegenerative, myodegenerative, infectious, and cancerous disorders. Autophagic processes are not only important for cellular maintenance in the retina but also intimately involved with phagocytosis and the very core of retinal visual process. Additionally, excessively upregulated autophagy may culminate into a cell death modality, which may be detrimental to the non-dividing cells of various eye segments. Major advances have been made in understanding the role and fate of autophagy in different ocular tissue layers. In this chapter, we summarize the current understanding of autophagy in the eye in the context of development, aging, and disease. We also speculate on the putative therapeutic strategies where autophagy may be incorporated to treat oculopathies.

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Aberrant visual pathway development in albinism: From retina to cortex

Ather

Proudlock

Welton

et al. 2018

Human Brain Mapping

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Albinism refers to a group of genetic abnormalities in melanogenesis that are associated neuronal misrouting through the optic chiasm. We perform quantitative assessment of visual pathway structure and function in 23 persons with albinism (PWA) and 20 matched controls using optical coherence tomography (OCT), volumetric magnetic resonance imaging (MRI), diffusion tensor imaging and visual evoked potentials (VEP). PWA had a higher streamline decussation index (percentage of total tractography streamlines decussating at the chiasm) compared with controls (Z = −2.24, p = .025), and streamline decussation index correlated weakly with inter‐hemispheric asymmetry measured using VEP (r = .484, p = .042). For PWA, a significant correlation was found between foveal development index and total number of streamlines (r = .662, p < .001). Significant positive correlations were found between peri‐papillary retinal nerve fibre layer thickness and optic nerve (r = .642, p < .001) and tract (r = .663, p < .001) width. Occipital pole cortical thickness was 6.88% higher (Z = −4.10, p < .001) in PWA and was related to anterior visual pathway structures including foveal retinal pigment epithelium complex thickness (r = −.579, p = .005), optic disc (r = .478, p = .021) and rim areas (r = .597, p = .003). We were unable to demonstrate a significant relationship between OCT‐derived foveal or optic nerve measures and MRI‐derived chiasm size or streamline decussation index. Our novel tractographic demonstration of altered chiasmatic decussation in PWA corresponds to VEP measured cortical asymmetry and is consistent with chiasmatic misrouting in albinism. We also demonstrate a significant relationship between retinal pigment epithelium and visual cortex thickness indicating that retinal pigmentation defects in albinism lead to downstream structural reorganisation of the visual cortex.

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Persistent hyaloid artery with an aberrant peripheral retinal attachment: A unique presentation

Cited by 10 publications

References 4 publications

Central retinal artery and vein occlusion as a complication of persistent hyaloid artery – a case report

Central retinal artery and vein occlusion as a complication of persistent hyaloid artery – a case report

Autophagy in Ocular Pathophysiology

Aberrant visual pathway development in albinism: From retina to cortex

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