2018
DOI: 10.1016/j.wneu.2018.04.088
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Persistent High Levels of miR-502-5p Are Associated with Poor Neurologic Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage

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Cited by 20 publications
(19 citation statements)
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“…Many studies have shown that there is a close relationship between SAH and miRNA in a variety of physiological and pathological aspects, such as signal pathway level, cellular level, and so on, and predict that miRNA will become one of the effective methods for the treatment of SAH in the future ( Su et al, 2015 ; Chen et al, 2017 ). It not only participates in inflammation, neuronal apoptosis, synaptic remodeling, and many other cellular functions but also detects the differential expression of miRNA in blood, cerebrospinal fluid (CSF) of SAH patients, and MCA of SAH model in rats ( Kikkawa et al, 2017 ; Sheng et al, 2018a , b ). Many disorders of miRNA expression are involved in the occurrence and development of CVS, and the detection of miRNA in EVs can be used as a new standard to prevent, diagnose, and judge the prognosis of CVS after SAH.…”
Section: Discussionmentioning
confidence: 99%
“…Many studies have shown that there is a close relationship between SAH and miRNA in a variety of physiological and pathological aspects, such as signal pathway level, cellular level, and so on, and predict that miRNA will become one of the effective methods for the treatment of SAH in the future ( Su et al, 2015 ; Chen et al, 2017 ). It not only participates in inflammation, neuronal apoptosis, synaptic remodeling, and many other cellular functions but also detects the differential expression of miRNA in blood, cerebrospinal fluid (CSF) of SAH patients, and MCA of SAH model in rats ( Kikkawa et al, 2017 ; Sheng et al, 2018a , b ). Many disorders of miRNA expression are involved in the occurrence and development of CVS, and the detection of miRNA in EVs can be used as a new standard to prevent, diagnose, and judge the prognosis of CVS after SAH.…”
Section: Discussionmentioning
confidence: 99%
“…SAH accounts for 5-7% of the total incidence of stroke [1,2]. A major prognostic determinant is the character of the initial hemorrhage that causes early brain injury (EBI) and early cerebral vasospasms (CVS) and may be associated with delayed cerebral ischemia (DCI) [3]. Several lines of evidence suggest that EBI after SAH may be the leading factor contributing to unfavorable outcomes following SAH [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…The potential of miRNAs serving as biomarkers for aSAH complications was recently explored in several reports (Su et al, 2015;Powers et al, 2016;Bache et al, 2017;Kikkawa et al, 2017;Lu et al, 2017;Stylli et al, 2017;Lopes et al, 2018; -Nicolas et al, 2018;Sheng et al, 2018a). These studies confirmed that dysregulated miRNA expression is associated with aSAH and its acute complications, which could be observed in extracellular fluids.…”
Section: Discussionmentioning
confidence: 76%