Persistent Genital Arousal Disorder Treated with Duloxetine: A Case Report

Gündüz, Nermin; Polat, Aslıhan; Turan, Hatice

doi:10.5080/u23441

Cited by 1 publication

(4 citation statements)

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“…Pharmacological therapy appears to be the most studied interventions to date for treating PGAD symptoms in many studies, most of them showing effectiveness in alleviating the symptoms of PGAD. 36,46,56 However, each study used different drugs and doses, making it difficult to determine which drug may be most effective and which are the mechanisms underlying their effectiveness. Furthermore, contradictory results were also found; for example, in the case of SSRIs, some authors 46,56 were able to demonstrate their effectiveness, while others did not find effective results.…”

Section: Discussionmentioning

confidence: 99%

“…36,46,56 However, each study used different drugs and doses, making it difficult to determine which drug may be most effective and which are the mechanisms underlying their effectiveness. Furthermore, contradictory results were also found; for example, in the case of SSRIs, some authors 46,56 were able to demonstrate their effectiveness, while others did not find effective results. 52,54 Physical therapies also appear to be particularly effective in the treatment of PGAD.…”

Section: Discussionmentioning

confidence: 99%

“…52 Duloxetine is another drug that has been used and reported as effective. In addition to being effective in the reduction of the symptoms of arousal, masturbation, and genital pain, 46,56 it is also effective in reducing the comorbid symptoms of anxiety and Mindfulness, paroxetine, mirtazapine, and ECT The patient initiated treatment with physiotherapy, but the exercises only improved the symptoms briefly. Anxiolytic and sleep medications (benzodiazepine, triazolam, melatonin, and zopiclone) were initiated, but did not provide the patient any relief.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

“…Oaklander, 2020 56 11 depression. 46 Treatment with this drug has also been effective in the partial reduction of the symptoms of PGAD in a woman with Tarlov cysts. 48 By contrast, a recent study found that only 2 of 11 cases of treatment with duloxetine was it effective in reducing the symptoms of PGAD.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

See 3 more Smart Citations

Treatments for Persistent Genital Arousal Disorder in Women: A Scoping Review

Martin-Vivar

Villena-Moya

Mestre‐Bach

et al. 2022

The Journal of Sexual Medicine

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Background Persistent genital arousal disorder (PGAD) is characterized by elevated discomfort associated with persistent genital arousal in the absence of sexual desire. Aim To perform a scoping review of the proposed treatments for PGAD and their efficacy. Methods A scoping review was carried out (PRISMA-Scr) that included articles on PGAD as the main disorder, only in women, which explained, in detail, the treatment and its efficacy, was empirical, was written in English and Spanish. No prior filtering by years was performed. Outcomes Three different effective treatments were found (physical therapies, pharmacological therapies, and psychotherapeutics in combination with other therapies). Results Thirty-eight articles were selected. From physical therapies, treatments using neuromodulation, transcutaneous electrical stimulation, Botox, surgery, electroconvulsive therapy, manual therapy, pelvic floor therapy, dietary changes, and transcranial magnetic stimulation showed effectiveness. Using the pharmacological approach, paroxetine, duloxetine, pramipexole, ropinirole, and clonazepam treatments were effective. Psychotherapy treatments showed effectiveness only in combination with other types of treatments, specifically a combination of cognitive–behavioral strategies with pharmacological treatment. Clinical implications Pharmacological treatment, specifically SSRIs, have proven to be the therapy of choice for different subtypes of patients. Strengths and limitations This study analyzed treatment effectiveness with different approaches and took into consideration those articles where psychotherapy was used as a combination treatment with pharmacological and physical therapy. The main limitation is that it was focused exclusively on women, and the results cannot be generalized to include men. Conclusions To date, a combination of pharmacological interventions with physical therapy and, in some occasions, with psychological therapy is main strategy followed to accomplish effective treatment of PGAD.

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