Persistent fatigue in liver transplant recipients: a two‐year follow‐up study

Ginneken, Berbke T J van; Berg-Emons, Rita J G van den; Windt, A. van der; Tilanus, H. W.; Metselaar, Herold J.; Stam, Henk J.; Kazemier, Geert

doi:10.1111/j.1399-0012.2009.01083.x

Cited by 58 publications

(66 citation statements)

References 40 publications

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“…30, nº 1 (enero) dicts negative post-transplant outcomes (Kelly et al, 2006;Zipfel et al, 2002). On the other hand, even in the posttransplant phase, because these patients do not achieve the well-being levels of the general population (Estraviz et al, 2007;Kousoulas et al, 2008) and mental health impairment predicts worse daily functioning -by means of fatigue- (Van Ginneken et al, 2010) and mortality after transplant (Pérez-San-Gregorio, Martín-Rodríguez, Galán-Rodríguez, & Borda-Más, 2009). Likewise, if the psychological complications at the pre-waiting-list-study phase are identified and treated, future disorders will be prevented in next stages such as at the waiting-list and post-transplant phases.…”

Section: Discussionmentioning

confidence: 99%

Funcionamiento biopsicosocial entre pacientes cirróticos en distin-tas etapas del proceso de trasplante y su comparación con trasplantados hepáticos.

et al. 2014

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Título: Funcionamiento biopsicosocial entre pacientes cirróticos en distintas etapas del proceso de trasplante y su comparación con trasplantados hepáticos. Resumen: Antecedentes: Si bien la evaluación de la calidad de vida en fases previas y posteriores al trasplante es un objetivo científico de actualidad; és-ta aún no ha sido abordada a lo largo de todo el proceso de trasplante. Objetivos: 1) Comparar la salud mental y calidad de vida en las tres siguientes fases del proceso de trasplante: en el estudio previo a la lista de espera, en lista de espera y en fase post-trasplante; 2) analizar la correlación entre estas variables afectivas y de calidad de vida y las puntuaciones en Model for End-Stage Liver Disease (MELD). Métodos: Se seleccionaron dos grupos de pacientes hepáticos: 51 pacientes cirróticos evaluados en dos etapas (en el estudio previo a la lista de espera y en lista de espera), y 51 pacientes con trasplante hepático procedente de un donante cadáver; ambos grupos igualados en género y edad mediante apareo. Se emplearon como instrumentos el HADS y el Cuestionario de Salud SF-36. Resultados: Los pacientes en estudio pre-lista de espera percibieron su estatus global de salud mucho peor que los pacientes trasplantados. Los pacientes en lista de espera presentaron mucha mayor ansiedad, más limitaciones funcionales por problemas fí-sicos, peor funcionamiento físico, y percibieron su estatus global de salud mucho peor que los pacientes trasplantados. Correlaciones estadísticamen-te significativas fueron únicamente observadas en los pacientes en lista de espera entre MELD y las subescalas de Ansiedad y Funcionamiento Social. Conclusiones: Los pacientes en lista de espera presentaron el peor estatus de bienestar biopsicosocial; por el contrario, los trasplantados hepáticos gozaron del mejor nivel en estas dimensiones. Palabras clave: Sintomatología ansioso-depresiva; calidad de vida; estudio pre-lista de espera; fase lista de espera; trasplante hepático. Abstract:Background: Although assessment of pre-and post-transplant quality of life is a current scientific target; it has not yet been carried out throughout the entire transplant process. Aims: 1) To analyze differences in mental health and quality of life at pre-waiting-list-study, waiting-list, and post-transplant phases; 2) to analyze correlation between these qualityof-life and affective variables and Model for End-Stage Liver Disease (MELD) scores. Methods: Two liver patient groups were recruited: 51 cirrhotic patients, who were assessed at two different stages (at pre-waitinglist-study and waiting-list phases), and 51 cadaveric liver transplant recipients; groups were homogeneous in gender and age variables by matching. Anxiety-depressive symptomatology and quality of life were assessed by HADS and SF-36 Health Survey, respectively. Results: Pre-waiting-list-study patients self-perceived their global health status much worse than transplant recipients. Waiting-list patients displayed much higher anxiety, more role limitations due to physical problem...

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Section: Discussionmentioning

confidence: 99%

Funcionamiento biopsicosocial entre pacientes cirróticos en distin-tas etapas del proceso de trasplante y su comparación con trasplantados hepáticos.

et al. 2014

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“…Fatigue appears to be a chronic problem after OLT with no change after 2 years, and there is a relation between fatigue and the physical domains of health-related quality of life. 23 It is well-known that these domains of health-related quality of life are reduced after liver transplant. 32 A possible explanation for the presence of fatigue after OLT might be that these patients have multiple comorbidities related to immuno suppressive therapy, such as osteoporosis, arterial hypertension, and chronic kidney disease.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 However, the few studies that have examined fatigue in OLT recipients have found that fatigue is still present after liver transplant and remains a major concern. [21][22][23] Reports about psychosocial outcome factors in recipients of liver and kidney transplant procedures are rare and have a limited number of cases. 24 The present crosssectional study aimed to identify clinical factors influencing fatigue and to measure fatigue in patients with a history of OLT and patients with a history of simultaneous/sequential liver and kidney transplant (LKTX) compared with the general population.…”

Section: Introductionmentioning

confidence: 99%

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Benzing

Krenzien²,

Krezdorn³

et al. 2017

Exp Clin Transplant

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Objectives: To date, fatigue is still poorly understood in recipients of orthotopic liver transplant and simultaneous/sequential liver and kidney transplant procedures. The present study examined the appearance of fatigue in patients who received orthotopic liver and sequential liver and kidney transplant procedures compared with the general population and the influence of various clinical and socioeconomic factors on fatigue levels. Materials and Methods: The Multidimensional Fatigue Inventory survey was sent to all patients with a history of orthotopic liver and simultaneous/sequential liver and kidney transplant. The results were compared to data from a reference population. Results: Our survey included 276 eligible patients: 256 recipients (92.7%) of orthotopic liver transplant and 20 recipients (7.3%) of simultaneous/sequential liver and kidney transplant. Significantly lower fatigue scores were found in the general population compared with both transplant groups (P < .001). There were also no significant differences between the transplant groups. Among the clinical and socioeconomic factors, history of hepatocellular carcinoma, chronic kidney disease, age, family status, and education had a significant impact on fatigue levels. Conclusions: This is the first study to compare fatigue in recipients of orthotopic liver and simultaneous/-sequential liver and kidney transplant. We found that fatigue is an important but still poorly understood outcome after transplant.

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“…However, in a 2-year follow-up study, fatigue remained a persistent problem for liver transplant patients. 23 Different liver disease diagnoses may be associated with different levels of fatigue postoperatively. In one study, physical fatigue continued to be a problem for transplant recipients diagnosed with cirrhosis.…”

Section: Fatiguementioning

confidence: 99%

“…17,18 Sleepiness and fatigue are also common events in patients with chronic liver disease, which can reduce their daily function and their health-related quality of life. [19][20][21][22][23] In addition, impaired neuropsychologic and cognitive functions, such as memory, have been common in liver disease patients and transplant recipients. [24][25][26][27][28] Such deficits may lead to nonadherence to medication and its debilitating consequences, including transplant rejection, infection, and even increased mortality.…”

Section: Introductionmentioning

confidence: 99%

Psychologic Evaluation in Liver Transplantation: Assessment of Psychologic Profile of End-Stage Liver Disease Patients Before and After Transplant

Baghernezhad

Mani²,

Ayoobzadehshirazi³

et al. 2020

Exp Clin Transplant

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Objectives: Patients with end-stage liver disease face various psychologic challenges. We aimed to compare levels of depression, anxiety, fatigue, sleepiness, and memory in patients before and after liver transplant. Materials and Methods: Forty patients (24 male, 16 female) were recruited from the liver transplant clinic affiliated with Shiraz University of Medical Sciences. Patients between 18 and 60 years old with at least a 6th-grade level of education were included in the study; those with severe psychiatric problems were excluded. We performed the following assessments before and 1 month after liver transplant: Hospital Anxiety and Depression questionnaires, California Verbal Learning Test, Epworth Sleepiness Scale, and Fatigue Severity Scale. Paired-sample t tests were used. P < .05 was considered significant. Results: Level of depression in study patients increased after transplant (7.42 vs 8.42; P = .008). We found improvements in categories of immediate memory (65.23 vs 60; P = .007), short delay free recall (10.52 vs 12.52; P < .001), short delay cued recall (11.42 vs 13.00; P = .001), long delay free recall (10.80 vs 12.50; P = .003), long delay cued recall (11.80 vs 13.25; P = .003), and recognition (14.65 vs 15.42; P = .003).Patient levels of fatigue (39.9 vs 33.2; P = .029) and sleepiness (10.8 vs 7.8; P = .004) decreased. Level of anxiety did not change significantly (12.6 vs 12.8; P = .642). Conclusions:We observed higher levels of depression but improved fatigue, sleepiness, and memory function in patients after liver transplant. No significant change in patient level of anxiety was seen. Future direction is discussed.

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Persistent fatigue in liver transplant recipients: a two‐year follow‐up study

Abstract: This longitudinal study shows that fatigue is a chronic problem after LTx and that daily functioning and HRQoL do not improve over time. This study supports the need for intervention programs to address fatigue after LTx.

Cited by 58 publications

References 40 publications

Funcionamiento biopsicosocial entre pacientes cirróticos en distin-tas etapas del proceso de trasplante y su comparación con trasplantados hepáticos.

Funcionamiento biopsicosocial entre pacientes cirróticos en distin-tas etapas del proceso de trasplante y su comparación con trasplantados hepáticos.

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Psychologic Evaluation in Liver Transplantation: Assessment of Psychologic Profile of End-Stage Liver Disease Patients Before and After Transplant

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