Persistent Epigenetic Reprogramming of Sweet Taste by Diet

Vaziri, Anoumid; Khabiri, Morteza; Genaw, Brendan T.; May, Christina E.; Freddolino, Peter L.; Dus, Monica

doi:10.1101/2020.03.25.007773

Cited by 3 publications

(2 citation statements)

References 98 publications

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“…This could be a delayed effect of the experienced starvation stress; prolonged vibrational stress can lead to reduced voluntary locomotion (Ries et al, 2017). Another possibility could be a long-lasting or even persistent effect on sensory perception (May et al, 2019;Vaziri et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

Mahishi

Triphan

Hesse

et al. 2021

Front. Behav. Neurosci.

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Animal behaviours are demonstrably governed by sensory stimulation, previous experience and internal states like hunger. With increasing hunger, priorities shift towards foraging and feeding. During foraging, flies are known to employ efficient path integration strategies. However, general long-term activity patterns for both hungry and satiated flies in conditions of foraging remain to be better understood. Similarly, little is known about how permanent contact chemosensory stimulation affects locomotion. To address these questions, we have developed a novel, simplistic fly activity tracking setup—the Panopticon. Using a 3D-printed Petri dish inset, our assay allows recording of walking behaviour, of several flies in parallel, with all arena surfaces covered by a uniform substrate layer. We tested two constellations of providing food: (i) in single patches and (ii) omnipresent within the substrate layer. Fly tracking is done with FIJI, further assessment, analysis and presentation is done with a custom-built MATLAB analysis framework. We find that starvation history leads to a long-lasting reduction in locomotion, as well as a delayed place preference for food patches which seems to be not driven by immediate hunger motivation.

show abstract

Section: Discussionmentioning

confidence: 99%

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

Mahishi

Triphan

Hesse

et al. 2021

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…This could be a delayed effect of the experienced starvation stress; prolonged vibrational stress can lead to reduced voluntary locomotion (Ries et al, 2017). Another possibility could be a long-lasting or even chronic effect on sensory perception (May et al, 2019;Vaziri et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Long-lasting impact of starvation experience on fly activity and place preference

Mahishi

Triphan

Hesse

et al. 2020

Preprint

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Animal behaviours are demonstrably governed by sensory stimulation, previous experience and internal states like hunger. With increasing hunger, priorities shift towards foraging and feeding. During foraging, flies are known to employ efficient path integration strategies. However, general long-term activity patterns for both hungry and satiated flies in conditions of foraging remain to be better understood. Similarly, little is known about how chronic contact chemosensory stimulation affects locomotion. To address these questions, we have developed a novel, simplistic fly activity tracking setup – the Panopticon. Using a 3D-printed Petri dish inset, our assay allows recording of walking behaviour, of several flies in parallel, with all arena surfaces covered by a uniform substrate layer. We tested two constellations of providing food: i) in single patches, and ii) omnipresent within the substrate layer. Fly tracking is done with FIJI, further assessment, analysis and presentation is done with a custom-built MATLAB analysis framework. We find that starvation history leads to a long-lasting reduction in locomotion, as well as a delayed place preference for food patches not driven by immediate hunger motivation.

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Dietary sugar inhibits satiation by decreasing the central processing of sweet taste

May

Rosander

Gottfried

et al. 2020

eLife

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From humans to vinegar flies, exposure to diets rich in sugar and fat lowers taste sensation, changes food choices, and promotes feeding. However, how these peripheral alterations influence eating is unknown. Here we used the genetically tractable organism D. melanogaster to define the neural mechanisms through which this occurs. We characterized a population of protocerebral anterior medial dopaminergic neurons (PAM DANs) that innervates the β’2 compartment of the mushroom body and responds to sweet taste. In animals fed a high sugar diet, the response of PAM-β’2 to sweet stimuli was reduced and delayed, and sensitive to the strength of the signal transmission out of the sensory neurons. We found that PAM-β’2 DANs activity controls feeding rate and satiation: closed-loop optogenetic activation of β’2 DANs restored normal eating in animals fed high sucrose. These data argue that diet-dependent alterations in taste weaken satiation by impairing the central processing of sensory signals.

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Persistent Epigenetic Reprogramming of Sweet Taste by Diet

Cited by 3 publications

References 98 publications

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

Long-lasting impact of starvation experience on fly activity and place preference

Dietary sugar inhibits satiation by decreasing the central processing of sweet taste

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