Persistent dysfunctional frontal lobe activation in former smokers

Neuhaus, Andres H.; Bajbouj, Malek; Kienast, Thorsten; Kalus, Peter; Haebler, Dorothea von; Winterer, Georg; Gallinat, Jürgen

doi:10.1007/s00213-006-0366-7

Cited by 71 publications

(70 citation statements)

References 69 publications

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“…Also implicating cholinergic factors in P300, Neuhaus et al (2006) reported reduced P300s in both current smokers (for about 20 years) and former smokers (about 12 years abstinence), relative to never smokers. This may point to a relatively strong disposition to indulge in smoking behavior in low-P300 individuals, perhaps to compensate low natural cholinergic transmission; or chronic smoking alters the cholinergic system and thereby P300 in an irreversible manner, perhaps through receptor desensitization.…”

Section: 'Attention' and Memory Updating: P300mentioning

confidence: 88%

“…Cholinergic transmission is an important determinant of P300 amplitude, a reflection of attention allocation predictive of subsequent memory, and probably based in a posterior cortical network, including temporal and parietal areas, as well as well possibly posterior cingulate cortex (Neuhaus et al, 2006). ACh further augments MMN (temporally and frontally) as well as P50 suppression, although the latter effect is believed to be indirect (Adler et al, 2004).…”

Section: Wrapping Up Neurotransmission Drugs and Cortical Processingmentioning

confidence: 99%

See 1 more Smart Citation

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Kenemans

Kähkönen

2010

Neuropsychopharmacol

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This review surveys human event-related brain potential (ERP) and event-related magnetic field (ERF) approaches to psychopharmacology and psychopathology, and the way in which they complement behavioral studies and other neuroimaging modalities. The major paradigms involving ERP/ERF are P50 suppression, loudness-dependent auditory evoked potential (LDAEP), mismatch negativity (MMN), P300, mental chronometry, inhibitory control, and conflict processing (eg, error-related negativity (ERN)). Together these paradigms cover a range of more bottom-up driven to more top-down controlled processes. A number of relationships between the major neurotransmitter systems and electrocortical mechanisms are highlighted. These include the role of dopamine in conflict processing, and perceptual processing vs motor preparation; the role of serotonin in P50 suppression, LDAEP, and MMN; glutamate/NMDA and MMN; and the role of acetylcholine in P300 generation and memory-related processes. A preliminary taxonomy for these relationships is provided, which should be helpful in attuning possible new treatments or new applications of existing treatments to various disorders.

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Section: 'Attention' and Memory Updating: P300mentioning

confidence: 88%

Section: Wrapping Up Neurotransmission Drugs and Cortical Processingmentioning

confidence: 99%

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Kenemans

Kähkönen

2010

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Neuhaus et al, (2006) revealed persistent fronto-striatal dysfunction in former smokers despite a mean of 11 years of abstinence from cigarette smoking. In addition to other functional differences, they reported decreased cortical activation in orbitofrontal and left dorsolateral prefrontal regions amongst previous smokers when completing an auditory oddball task.…”

Section: Executive Function Treatment Recovery In Nicotine Dependencementioning

confidence: 98%

Substance Dependence as a Neurological Disorder

Meil¹,

LaPorte²,

Stewart³

2012

Advanced Topics in Neurological Disorders

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“…However, research has yielded mixed results. Impairment of response inhibition among smokers continues across 3 months of abstinence [28] and hypoactivation in the frontal lobes has been observed among long term abstainers [29] suggesting executive deficits may persist among smokers. In contrast, other research maintains executive dysfunction associated with tobacco addiction may be more malleable.…”

Section: Journal Of Addiction Research and Therapymentioning

confidence: 99%

“…Tobacco dependence was measured via the Fagerstrom Test of Nicotine Dependence (FTND) [40]. Most studies of executive deficits and nicotine addiction have employed cross sectional research designs [12,29,30] or measured executive abilities initially and related them to subsequent treatment attrition or outcomes [31,32]. This study was relatively unique in that it assessed executive abilities in the same participants prior to treatment and approximately one and a half months after the initiation of treatment.…”

Section: Journal Of Addiction Research and Therapymentioning

confidence: 99%

Changes in Executive Function Following Short-Term Tobacco Cessation Therapy in College Students

Meil¹,

Sesti²,

Desai³

et al. 2017

J Addict Res Ther

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Objective: Evidence has been accumulating regarding the role of executive deficits in nicotine addiction; however, little is known as to whether executive abilities change as a function of treatment for nicotine dependence. The purpose of this study was to investigate whether executive function improves following short-term tobacco cessation therapy. Methods:College students (N=17) expressing an interest in tobacco cessation therapy involving Motivational Interviewing Therapy with or without the nicotine patch were administered the self-report Frontal Systems Behavioral Scale (FrSBe), the performance-based Delis-Kaplan Executive Function System (D-KEFS) and the Fagerstrom Test of Nicotine Dependence (FTND) prior to treatment and approximately 1.5 months later. A group of non-smoking college students (N=19) was also administered the same measures of executive function across the same time period.Results: Prior to treatment smokers had significantly higher FrSBe Apathy subscale scores compared to nonsmokers. Acute tobacco cessation therapy significantly decreased nicotine dependence as measured by the FTDN. After controlling for pre-treatment scores, a significant difference emerged between tobacco cessation participants and non-smoking controls on post-test FrSBe Disinhibition scores. Post hoc analyses revealed a significant improvement in FrSBe Disinhibition scores among tobacco cessation participants, but no change among nonsmokers. Conclusion:While caution is warranted due to the small sample size of this study, these results suggest selfreport measures of executive function maybe more sensitive to executive deficits among smokers and change following short-term tobacco cessation therapy, particularly measures indicative of an improved ability to inhibit impulses and behavior. These results also highlight the multidimensional nature of executive function.

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Persistent dysfunctional frontal lobe activation in former smokers

Abstract: For the first time, evidence is provided that dysfunctional activation of frontal lobe networks in smokers is also present in long term abstainers.

Cited by 71 publications

References 69 publications

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Substance Dependence as a Neurological Disorder

Changes in Executive Function Following Short-Term Tobacco Cessation Therapy in College Students

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