Persistent ductus arteriosus complicating the respiratory distress syndrome.

Jones, R. Watson; Pickering, D

doi:10.1136/adc.52.4.274

Cited by 42 publications

(21 citation statements)

References 28 publications

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“…Recovery from RDS is clearly improved by ductal closure during the first 2 weeks of life [1][2][3][4][5][6][7][8][9][10]. Neither the frequency nor the significance of ductal patency after the first 2 weeks of life is known.…”

Section: Discussionmentioning

confidence: 99%

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Ductus Arteriosus in Premature Infants Beyond the Second Week of Life

Carboni

Ringel

1997

Pediatr Cardiol

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Persistent patency of the ductus arteriosus (PDA), common in premature infants, is associated with severe respiratory distress. The likelihood and significance of finding PDA in premature infants beyond the second week of life is unknown. We retrospectively analyzed all echocardiograms obtained between 1987 and 1992 on infants <35 weeks' gestational age. Of 446 echocardiograms 77 were obtained from infants >/=14 days. Of the 77 infants, 17 (22%) were found to have PDA (group 1) and the remainder did not (group 2). Forty-eight infants had been diagnosed as having PDA prior to 14 days of age. Of these infants, 16 were from group 1. Thus only 1/17 (6%) infants diagnosed as having PDA after 2 weeks did not have a history of PDA. The presence of PDA after 2 weeks did not relate to duration of oxygen therapy, ventilator therapy, or hospital stay. Furthermore, late closure of PDA in a subgroup of 11 infants did not appear to affect these parameters. It was concluded that premature infants beyond the second week of life are unlikely to have PDA if PDA had not been diagnosed during the first 14 days. Closure of PDA beyond the second week may not improve the infant's respiratory status.

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Section: Discussionmentioning

confidence: 99%

“…Persistent patency of the ductus arteriosus (PDA) has been associated with acute respiratory decompensation and the need for prolonged ventilatory assistance in these infants [1,2,5,6,8,10].…”

mentioning

confidence: 99%

Ductus Arteriosus in Premature Infants Beyond the Second Week of Life

Carboni

Ringel

1997

Pediatr Cardiol

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“…1 Over the following two decades, the hemodynamic and pulmonary consequences of delayed ductal closure provided a compelling rationale for treatment to close the ductus. In landmark papers, patent ductus arteriosus (PDA) in infants with RDS was linked to bronchopulmonary dysplasia (BPD) by Northway et al, 2 prolonged ventilation by Siassi et al, 3 mortality by Gregory et al, 4 and worsening pulmonary disease by Kitterman et al 5 Subsequent studies confirmed the association of PDA with pulmonary hemorrhage, 6,7 severe RDS, 8,9 BPD, [10][11][12] necrotizing enterocolitis (NEC), 13,14 renal impairment, 15 intraventricular hemorrhage (IVH), 16,17 periventricular leukomalacia (PVL), 18 cerebral palsy, 19 and death. 20,21 Even now, the adjusted risk of death is increased four- 22 to eightfold 23 for very low birth weight (<1500 g) infants in whom the ductus remains patent after medical therapy.…”

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confidence: 80%

Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?

2010

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“…When surgical ligation is delayed until medical man agement has failed the outcome in most re ported series is also poor (5,9,13,15). Earlier ligation has therefore been suggested in order to avoid the progressive deterioration in lung func tion associated with the persistence of the PDA and mechanical ventilation (8,12,15,22).…”

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confidence: 99%

Lung Compliance in Newborns with Patent Ductus Arteriosus before and after Surgical Ligation

Gerhardt

Bancalari²

1980

Neonatology

105

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Pressure volume curves of the lungs were determined in 10 premature infants (mean gestational age 31.4 weeks, mean birth weight 1,260 g) before and after surgical ligation of a patent ductus arteriosus (PDA). 7 infants who had low compliance initially showed a significant improvement in lung compliance after surgery, while 3 infants whose compliance was close to normal before surgery had a decrease after ligation. In conclusion, a PDA with left to right shunt is frequently associated with a decrease in lung compliance that improves after ligation. Measurement of lung compliance in infants with PDA can be helpful in predicting the degree of improvement in lung function that may result from the closure of the ductus.

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Persistent ductus arteriosus complicating the respiratory distress syndrome.

Cited by 42 publications

References 28 publications

Ductus Arteriosus in Premature Infants Beyond the Second Week of Life

Ductus Arteriosus in Premature Infants Beyond the Second Week of Life

Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?

Lung Compliance in Newborns with Patent Ductus Arteriosus before and after Surgical Ligation

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