Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease

Zhang, Yujue; Fan, Yuanyuan; He, Wei; Han, Yi; Bao, Huarui; Yang, Renjun; Wang, Bingbing; Kong, Deyan

doi:10.1186/s13578-021-00664-8

Cited by 15 publications

(9 citation statements)

References 36 publications

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“…It follows that organ systems which rely on immune signaling for proper functioning are also impaired. Some systems, like the nervous system may be altered in subtle ways that alter behavior ( 75 ). In contrast, systems which directly encounter pathogens from the environment can become more susceptible to infection and injury ( 76 , 77 ).…”

Section: Discussionmentioning

confidence: 99%

Innate lymphocytes: Role in alcohol-induced immune dysfunction

2022

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Alcohol use is known to alter the function of both innate and adaptive immune cells, such as neutrophils, macrophages, B cells, and T cells. Immune dysfunction has been associated with alcohol-induced end-organ damage. The role of innate lymphocytes in alcohol-associated pathogenesis has become a focus of research, as liver-resident natural killer (NK) cells were found to play an important role in alcohol-associated liver damage pathogenesis. Innate lymphocytes play a critical role in immunity and homeostasis; they are necessary for an optimal host response against insults including infections and cancer. However, the role of innate lymphocytes, including NK cells, natural killer T (NKT) cells, mucosal associated invariant T (MAIT) cells, gamma delta T cells, and innate lymphoid cells (ILCs) type 1–3, remains ill-defined in the context of alcohol-induced end-organ damage. Innate-like B lymphocytes including marginal zone B cells and B-1 cells have also been identified; however, this review will address the effects of alcohol misuse on innate T lymphocytes, as well as the consequences of innate T-lymphocyte dysfunction on alcohol-induced tissue damage.

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Section: Discussionmentioning

confidence: 99%

Innate lymphocytes: Role in alcohol-induced immune dysfunction

2022

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“… 88 Previously, Riva et al 89 reported that peripheral blood MAIT cell frequency was significantly lower in patients with ALD (alcohol-related cirrhosis and severe alcoholic hepatitis) than in healthy volunteers, especially in patients with severe alcoholic hepatitis, where the decrease was most obvious. According to Zhang et al, 90 the combined effects of IL-12, IL-18, and IL-8 could be responsible for the decrease in MAIT cells in patients with ALD. Compared with control subjects, peripheral blood MAIT cells expressed higher levels of CD69 and HLA-DR, but produced significantly less IL-17, granzyme B, and CD107a.…”

Section: Mucosal-associated Invariant T Cells In Hepatobiliary Diseasesmentioning

confidence: 97%

Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer?

Zhang

Shen

Zhou

et al. 2023

Cellular and Molecular Gastroenterology and Hepatology

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“…As mentioned above, our group recently identified a novel population of human FoxP3 + T2NKT cells that might exert immunoregulatory functions in this scenario ( 40 ). Alcoholic-related cirrhosis and severe alcoholic hepatitis patients had a dramatic depletion and hyperactivated circulating MAIT cells ( 127 , 128 ). Dysfunctional MAIT cells could explain the susceptibility to infection of these patients ( 127 , 128 ).…”

Section: Alcohol-induced Hepatitis and Drugsmentioning

confidence: 99%

Innate immunity and early liver inflammation

Zhou

2023

Front. Immunol.

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The innate system constitutes a first-line defence mechanism against pathogens. 80% of the blood supply entering the human liver arrives from the splanchnic circulation through the portal vein, so it is constantly exposed to immunologically active substances and pathogens from the gastrointestinal tract. Rapid neutralization of pathogens and toxins is an essential function of the liver, but so too is avoidance of harmful and unnecessary immune reactions. This delicate balance of reactivity and tolerance is orchestrated by a diverse repertoire of hepatic immune cells. In particular, the human liver is enriched in many innate immune cell subsets, including Kupffer cells (KCs), innate lymphoid cells (ILCs) like Natural Killer (NK) cells and ILC-like unconventional T cells – namely Natural Killer T cells (NKT), γδ T cells and Mucosal-associated Invariant T cells (MAIT). These cells reside in the liver in a memory-effector state, so they respond quickly to trigger appropriate responses. The contribution of aberrant innate immunity to inflammatory liver diseases is now being better understood. In particular, we are beginning to understand how specific innate immune subsets trigger chronic liver inflammation, which ultimately results in hepatic fibrosis. In this review, we consider the roles of specific innate immune cell subsets in early inflammation in human liver disease.

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Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease

Cited by 15 publications

References 36 publications

Innate lymphocytes: Role in alcohol-induced immune dysfunction

Innate lymphocytes: Role in alcohol-induced immune dysfunction

Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer?

Innate immunity and early liver inflammation

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