Persistent cough and asthma-like symptoms post COVID-19 hospitalization in children

Esmaeilzadeh, Hossein; Dashti, Anahita Sanaei; Mortazavi, Negar; Fatemian, Hossein; Vali, Mohebat

doi:10.1186/s12879-022-07252-2

Cited by 28 publications

(22 citation statements)

References 25 publications

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“…Children were more often found to be asymptomatic or mildly affected (9,10). If symptoms were present, usually, headache, fatigue, fever, cough and sore throat were predominant, while hypoxemia and dyspnea remained rare (9)(10)(11). In general, illness duration was reported as shorter in children than in adults (10).…”

Section: Introductionmentioning

confidence: 99%

Exhaled Aerosols in SARS-CoV-2 Polymerase Chain Reaction-Positive Children and Age-Matched-Negative Controls

et al. 2022

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BackgroundChildren and adolescents seem to be less affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease in terms of severity, especially until the increasing spread of the omicron variant in December 2021. Anatomical structures and lower number of exhaled aerosols may in part explain this phenomenon. In a cohort of healthy and SARS-CoV-2 infected children, we compared exhaled particle counts to gain further insights about the spreading of SARS-CoV-2.Materials and MethodsIn this single-center prospective observational trial, a total of 162 children and adolescents (age 6–17 years), of whom 39 were polymerase chain reaction (PCR)-positive for SARS-CoV-2 and 123 PCR-negative, were included. The 39 PCR-positive children were compared to 39 PCR-negative age-matched controls. The data of all PCR-negative children were analyzed to determine baseline exhaled particle counts in children. In addition, medical and clinical history was obtained and spirometry was measured.ResultsBaseline exhaled particle counts were low in healthy children. Exhaled particle counts were significantly increased in SARS-CoV-2 PCR-positive children (median 355.0/L; range 81–6955/L), compared to age-matched -negative children (median 157.0/L; range 1–533/L; p < 0.001).ConclusionSARS-CoV-2 PCR-positive children exhaled significantly higher levels of aerosols than healthy children. Overall children had low levels of exhaled particle counts, possibly indicating that children are not the major driver of the SARS-CoV-2 pandemic.Trial Registration[ClinicalTrials.gov], Identifier [NCT04739020].

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Section: Introductionmentioning

confidence: 99%

Exhaled Aerosols in SARS-CoV-2 Polymerase Chain Reaction-Positive Children and Age-Matched-Negative Controls

et al. 2022

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“…Asthma is one of the most prevalent chronic diseases in the United States, and respiratory infections are frequently thought to be asthma triggers (Esmaeilzadeh et al, 2022). Patients with acute asthma attacks frequently describe upper respiratory symptoms, including cough, in the days before the exacerbation starts (Pattemore et al, 1992).…”

Section: Resultsmentioning

confidence: 99%

COVID-19 respiratory sound analysis and classification using audio textures

Silva

Valadão²,

Lampier³

et al. 2022

Front. Signal Process.

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Since the COVID-19 outbreak, a major scientific effort has been made by researchers and companies worldwide to develop a digital diagnostic tool to screen this disease through some biomedical signals, such as cough, and speech. Joint time–frequency feature extraction techniques and machine learning (ML)-based models have been widely explored in respiratory diseases such as influenza, pertussis, and COVID-19 to find biomarkers from human respiratory system-generated acoustic sounds. In recent years, a variety of techniques for discriminating textures and computationally efficient local texture descriptors have been introduced, such as local binary patterns and local ternary patterns, among others. In this work, we propose an audio texture analysis of sounds emitted by subjects in suspicion of COVID-19 infection using time–frequency spectrograms. This approach of the feature extraction method has not been widely used for biomedical sounds, particularly for COVID-19 or respiratory diseases. We hypothesize that this textural sound analysis based on local binary patterns and local ternary patterns enables us to obtain a better classification model by discriminating both people with COVID-19 and healthy subjects. Cough, speech, and breath sounds from the INTERSPEECH 2021 ComParE and Cambridge KDD databases have been processed and analyzed to evaluate our proposed feature extraction method with ML techniques in order to distinguish between positive or negative for COVID-19 sounds. The results have been evaluated in terms of an unweighted average recall (UAR). The results show that the proposed method has performed well for cough, speech, and breath sound classification, with a UAR up to 100.00%, 60.67%, and 95.00%, respectively, to infer COVID-19 infection, which serves as an effective tool to perform a preliminary screening of COVID-19.

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“…In addition, since the role of “Long COVID-19 Syndrome” (LCS) has recently been brought to the attention of the scientific community, there has consequently been interested in the relationship between this LCS and allergies. Several studies have already reported that allergies seem to be associated with a higher risk of persistent symptoms during the follow-up period post-infection [ 13 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19, Anosmia, and Allergies: Is There a Relationship? A Pediatric Perspective

Brindisi

Spalice

Anania

et al. 2022

JCM

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Background: Between June and July 2020, we evaluated children and adolescents concerning post-infection surveillance after a COVID-19 positivity during the lockdown. We aimed to assess whether the anamnestic presence of allergies could correlate with the presence of SARS-CoV-2 symptoms, and in particular with anosmia. Material and methods: For each patient, we collected anamnestic data, the presence of allergies documented by performing skin prick tests, and COVID-19 symptoms. Then, if over six years of age, each patient underwent an active anterior rhinomanometry. Results: A total of 296 patients were enrolled, of whom 105 (35.4%) reported allergies. Considering COVID-19 symptoms, 74 subjects (25%) presented an asymptomatic form, 222 (75%) reported symptoms, and anosmia recurred in 60 subjects (27.03%). A statistically significant relationship was found between allergies and symptomatic COVID-19 (p = 0.042), allergies, and anosmia (p = 0.05), and allergies and anosmia in males (p = 0.007). Moreover, anosmic patients presented a higher body mass index, older age, and a longer COVID-19 duration with statistical significance (p = 0.001, 0.001, 0.006, respectively). Conclusions: Allergic subjects seem to develop symptomatic COVID-19 more frequently and allergies appear to be a protective factor from anosmia’s onset in males.

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Persistent cough and asthma-like symptoms post COVID-19 hospitalization in children

Cited by 28 publications

References 25 publications

Exhaled Aerosols in SARS-CoV-2 Polymerase Chain Reaction-Positive Children and Age-Matched-Negative Controls

Exhaled Aerosols in SARS-CoV-2 Polymerase Chain Reaction-Positive Children and Age-Matched-Negative Controls

COVID-19 respiratory sound analysis and classification using audio textures

COVID-19, Anosmia, and Allergies: Is There a Relationship? A Pediatric Perspective

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