Persistent changes in nociceptor translatomes govern hyperalgesic priming in mouse models
Ishwarya Sankaranarayanan,
Moeno Kume,
Ayaan Mohammed
et al.
Abstract:Hyperalgesic priming is a model system that has been widely used to understand plasticity in painful stimulus-detecting sensory neurons, called nociceptors. A key feature of this model system is that following priming, stimuli that do not normally cause hyperalgesia now readily provoke this state. We hypothesized that hyperalgesic priming occurs due to reorganization of translation of mRNA in nociceptors. To test this hypothesis, we used paclitaxel treatment as the priming stimulus and translating ribosome aff… Show more
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