Persistent Bloodstream Infection with Kocuria rhizophila Related to a Damaged Central Catheter

Moissenet, Didier; Becker, Karsten; Mérens, Audrey; Ferroni, Agnès; Dubern, B.; Vu-Thien, Hoang

doi:10.1128/jcm.06038-11

Cited by 48 publications

(41 citation statements)

References 33 publications

(18 reference statements)

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“…These patients had mainly bacteremia/recurrent sepsis. [1][2][3][4][5] It is noticeable, however, that the immunocompromise was not mandatory in all reported cases. 3 Most pediatric cases were caused by K. kristinae; K. rosea was only described in one child until now, with peritonitis 2-7 ( Table 1).…”

mentioning

confidence: 63%

Endocarditis by Kocuria rosea in an immunocompetent child

Moreira

Riccetto

Silva

et al. 2015

The Brazilian Journal of Infectious Diseases

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Kocuria rosea belongs to genus Kocuria (Micrococcaceae family, suborder Micrococcineae, order Actinomycetales) that includes about 11 species of bacteria. Usually, Kocuria sp are commensal organisms that colonize oropharynx, skin and mucous membrane; Kocuria sp infections have been described in the last decade commonly affecting immunocompromised patients, using intravenous catheter or peritoneal dialysis. These patients had mainly bacteremia/recurrent sepsis. We hereby describe the case of a 10-year-old girl, immunocompetent, who had endocarditis/sepsis by K. rosea which was identified in five different blood cultures by Vitek 2 ID-GPC card (BioMérieux, France). Negative HIV serology, blood count within normal range of leukocytes/neutrophils and lymphocytes, normal fractions of the complement, normal level of immunoglobulins for the age; lymphocyte immunophenotyping was also within the expected values. Thymus image was normal at chest MRI. No catheters were required. Identification of K. rosea was essential to this case, allowing the differentiation of coagulase-negative staphylococci and use of an effective antibiotic treatment. Careful laboratory analysis of Gram-positive blood-born infections may reveal more cases of Kocuria sp infections in immunocompetent patients, which may collaborate for a better understanding, prevention and early treatment of these infections in pediatrics.

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mentioning

confidence: 63%

Endocarditis by Kocuria rosea in an immunocompetent child

Moreira

Riccetto

Silva

et al. 2015

The Brazilian Journal of Infectious Diseases

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“…This is in contrast to the high abundance of Propionibacterium , Corynebacterium , and Staphylococcus commonly found on human skin [3], which only represented 0.0045 ± 0.006% of sequences, 0.33 ± 0.3%, and 0.57 ± 0.5% of the pig skin bacteriome, respectively. While Kocuria rhizophila , the fourth most abundant species in our samples, has been shown to cause systemic infection, its role in cutaneous wound healing is unclear [35]. …”

Section: Discussionmentioning

confidence: 99%

Initial Characterization of the Pig Skin Bacteriome and Its Effect on In Vitro Models of Wound Healing

et al. 2016

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Elucidating the roles and composition of the human skin microbiome has revealed a delicate interplay between resident microbes and wound healing. Evolutionarily speaking, normal cutaneous flora likely has been selected for because it potentiates or, at minimum, does not impede wound healing. While pigs are the gold standard model for wound healing studies, the porcine skin microbiome has not been studied in detail. Herein, we performed 16S rDNA sequencing to characterize the pig skin bacteriome at several anatomical locations. Additionally, we used bacterial conditioned-media with in vitro techniques to examine the paracrine effects of bacterial-derived proteins on human keratinocytes (NHEK) and fibroblasts (NHDF). We found that at the phyla level, the pig skin bacteriome is similar to that of humans and largely consists of Firmicutes (55.6%), Bacteroidetes (20.8%), Actinobacteria (13.3%), and Proteobacteria (5.1%) however species-level differences between anatomical locations exist. Studies of bacterial supernatant revealed location-dependent effects on NHDF migration and NHEK apoptosis and growth factor release. These results expand the limited knowledge of the cutaneous bacteriome of healthy swine, and suggest that naturally occurring bacterial flora affects wound healing differentially depending on anatomical location. Ultimately, the pig might be considered the best surrogate for not only wound healing studies but also the cutaneous microbiome. This would not only facilitate investigations into the microbiome’s role in recovery from injury, but also provide microbial targets for enhancing or accelerating wound healing.

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“…Indeed, it has been reported that Kocuria can cause bacteraemia in chronically ill patients with malignancies or in immunosuppressed states (Basaglia et al, 2002;Martinaud et al, 2008). Kocuria infection has been linked to cases of peritonitis associated with peritoneal dialysis (Altuntas et al, 2004;Lee et al, 2009;Meletis et al, 2012), acute cholecystitis (Ma et al, 2005), catheter-related bacteraemia (Dunn et al, 2011;Lai et al, 2011;Moissenet et al, 2012), infective endocarditis (Lai et al, 2011) and brain abscesses (Tsai et al, 2010). Here, we describe the first known case of Kocuria dacryocystitis in an immunocompetent patient.…”

Section: Introductionmentioning

confidence: 76%

Kocuria dacryocystitis infection, caused by kocuria ocularis sp. Nov.

Domont¹,

Flèche‐Matéos

Brémond‐Gignac

et al. 2014

JMM Case Reports

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Introduction: Kocuria spp. rarely cause infectious disease but can be opportunistic pathogens in immunocompromised patients. The numbers of documented infections are low but rising.Case presentation: A 74-year-old woman presented with acute, painful swelling of the medial canthus of the left eye. The skin surface was red and acutely painful to the touch. Because of several clinical relapses despite antibiotic treatment, surgical dacryocystorhinostomy with marsupialization of the lacrimal sac into the nasal cavity was performed. Lacrimal sac drainage samples were analysed and yielded Kocuria. This is, to our knowledge, the first case of Kocuria dacryocystitis. Furthermore, the dacryocystitis was caused by a novel species of Kocuria, which we suggest should be named Kocuria ocularis.Conclusion: Kocuria related to ocular infection has not yet been documented. This report expands the clinical spectrum of diseases caused by these potentially underestimated pathogens.

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Persistent Bloodstream Infection with Kocuria rhizophila Related to a Damaged Central Catheter

Cited by 48 publications

References 33 publications

Endocarditis by Kocuria rosea in an immunocompetent child

Endocarditis by Kocuria rosea in an immunocompetent child

Initial Characterization of the Pig Skin Bacteriome and Its Effect on In Vitro Models of Wound Healing

Kocuria dacryocystitis infection, caused by kocuria ocularis sp. Nov.

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