Persistent blood eosinophilia and eosinophil activation marker in a severe case of eosinophilic gastroenteritis associated with multiple food allergies

Leru, Polliana Mihaela; Anton, Vlad Florin; Zacheu, Horia; Voiosu, Theodor; Matei, Dumitru

doi:10.2478/rrlm-2018-0026

Cited by 2 publications

(3 citation statements)

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“…Allergic diseases are usually accompanied by blood eosinophilia, usually in moderate range and this can be asymptomatic for variable periods of time. The preclinical phase of eosinophilia may suggest the period of hypersensitization to food allergens, before clinically manifested food allergies, with severe forms in rare cases, such as EGE [ 12 ]. In this context, blood eosinophilia may not be considered a trivial laboratory parameter and early evaluation and identification of causal disease could improve medium and long-term prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of this manuscript is to present the five-year follow-up and outcome of a rare case of eosinophilic gastroenteritis with oesophageal involvement, associated with persistent blood eosinophilia, asthma and multiple food allergies in a young male adult and to outline some relevant diagnostic and problematic aspects reviewed in the literature on this topic. The summary of the data from the initial presentation of the patient were presented in a Letter to the Editor published in 2018 [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Follow-Up of a Rare Case of Eosinophilic Gastroenteritis Associated with Persistent Blood Eosinophilia and Multiple Food Allergies

et al. 2022

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Eosinophilic gastroenteritis (EGE) is a subgroup of the eosinophilic gastro-intestinal disorders (EGIDs), characterized by eosinophilic infiltration and chronic inflammation of the gastrointestinal tract. These are rare diseases with still incompletely elucidated causes and mechanisms, with frequently delayed diagnosis and variable outcome. Despite increased interest in eosinophilic diseases in recent years, fewer data have been published on EGE and no standardized diagnostic and therapeutic approach exists. This paper reports the case of a young male patient diagnosed with EGE in 2017 based on clinical and histopathological criteria and constantly monitored during five years. Besides gastrointestinal eosinophilic infiltration, biopsies also revealed eosinophilic infiltration of the oesophagus, despite no declared characteristic oesophageal symptoms. We found increased specific IgE to multiple foods and progressive blood hypereosinophilia which preceded EGE diagnosis by three years. The EGE management included selective dietary restrictions and pharmacologic therapy based on daily budesonide non-enteric coated tablets, proton pumps inhibitors, antihistamines, cromoglycate, correction of iron, calcium and vitamin D deficiencies. The clinical outcome was good, while blood eosinophilia and endoscopic appearance remained almost unchanged. After one year the patient complained of respiratory symptoms suggesting asthma, needing continuous combined inhaled therapy. The reported case is illustrative for complex presentation, diagnosis and outcome of a rare case of mucosal chronic EGE associated with oesophageal involvement, peripheral eosinophilia, multiple food allergies and asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Follow-Up of a Rare Case of Eosinophilic Gastroenteritis Associated with Persistent Blood Eosinophilia and Multiple Food Allergies

et al. 2022

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“…Eosinophilic disorders of the gastrointestinal tract, mainly eosinophilic esophagitis, gastroenteritis and colitis, may be accompanied by peripheral eosinophilia in a significant number of patients and this is considered an independent predictor of relapsing disease. It was reported that progressive blood eosinophilia associated with multiple food allergies may precede onset of gastrointestinal symptoms with months-years, confirming the importance of early allergist evaluation in the diagnosis work-up of hypereosinophilia [12].…”

Section: The Concept Of Hypereosinophilic Syndromementioning

confidence: 96%

Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm

Leru

2019

Clin Transl Allergy

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Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades, with consistent progress made regarding understanding of molecular mechanisms, refining of diagnostic criteria, classification and evaluation of therapeutic options. There are still many gaps and difficulties in evaluating eosinophilic syndromes and diseases in medical practice. The disease prognosis depends mainly on the cause and mechanism of eosinophilia, on severity of organ dysfunction and on accurate diagnosis and response to treatment. Besides primary hypereosinophilic syndromes and secondary (reactive) eosinophilias, many associated or idiopathic forms have been described, making this topic a complex and difficult medical entity. An important aim of the experts in the field is to agree upon a more clear and practically useful classification, a better characterization of various phenotypes and endotypes of eosinophilic diseases and to identify novel biomarkers and more effective therapies. The aim of this paper is to review recent data from the literature regarding definition, classification and diagnosis criteria of eosinophilic diseases and to propose a revised and updated diagnostic algorithm useful in clinical practice.

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Persistent blood eosinophilia and eosinophil activation marker in a severe case of eosinophilic gastroenteritis associated with multiple food allergies

Cited by 2 publications

References 10 publications

Follow-Up of a Rare Case of Eosinophilic Gastroenteritis Associated with Persistent Blood Eosinophilia and Multiple Food Allergies

Follow-Up of a Rare Case of Eosinophilic Gastroenteritis Associated with Persistent Blood Eosinophilia and Multiple Food Allergies

Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm

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