Persistent aryl hydrocarbon receptor inducers increase with altitude, and estrogen-like disrupters are low in soils of the Alps

Levy, Walkiria; Henkelmann, Bernhard; Bernhöft, Silke; Bovee, Toine F.H.; Buegger, Franz; Jakobi, Gert; Kirchner, M.; Bassan, Rodolfo; Kräuchi, Norbert; Moche, Wolfgang; Offenthaler, Ivo; Simončić, Primož; Weiß, Peter; Schramm, K.‐W.

doi:10.1007/s11356-010-0361-8

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…The triolein was removed by passing the residue through a C18 SPE cartridge for which acetonitrile was used as eluting solvent. The extract was blown to dryness with a gentle nitrogen flow and then the residue was dissolved in a mixture of DMSO/isopropanol 4:1(v/v) for Micro-EROD bioassay (Levy et al, 2011).…”

Section: Sample Extraction and Clean Upmentioning

confidence: 99%

Combined chemical and toxicological long-term monitoring for AhR agonists with SPMD-based virtual organisms in drinking water Danjiangkou Reservoir, China

Wang

Guo-qiang

et al. 2014

Chemosphere

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Section: Sample Extraction and Clean Upmentioning

confidence: 99%

Combined chemical and toxicological long-term monitoring for AhR agonists with SPMD-based virtual organisms in drinking water Danjiangkou Reservoir, China

Wang

Guo-qiang

et al. 2014

Chemosphere

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“…The volumes of the extract solutions were reduced to about 2 mL using a vacuum rotary evaporator. The residue was further purified through a C18 SPE cartridge for which a mixture of acetonitrile/dichloromethane 95:5 was used as eluting solvent (Levy et al 2011). Finally, the extract was gently blown to dryness with nitrogen and redissolved in 200 μL DMSO/ isopropanol 4:1 (v /v ) to be ready for EROD and yeast bioassays.…”

Section: Sample Collection and Preparationmentioning

confidence: 99%

Aryl hydrocarbon receptor (AhR) inducers and estrogen receptor (ER) activities in surface sediments of Three Gorges Reservoir, China evaluated with in vitro cell bioassays

Wang

Bovee²,

et al. 2013

Environ Sci Pollut Res

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Two types of biological tests were employed for monitoring the toxicological profile of sediment cores in the Three Gorges Reservoir (TGR), China. In the present study, sediments collected in June 2010 from TGR were analyzed for estrogen receptor (ER)-and aryl hydrocarbon receptor (AhR)-mediated activities. The estrogenic activity was assessed using a rapid yeast estrogen bioassay, based on the expression of a green fluorescent reporter protein. Weak anti-estrogenic activity was detected in sediments from an area close to the dam of the reservoir, and weak estrogenic activities ranging from 0.3 to 1 ng 17β-estradiol (E2) equivalents (EQ) g −1 dry weight sediment (dw) were detected in sediments from the Wanzhou to Guojiaba areas. In the upstream areas Wanzhou and Wushan, sediments demonstrated additive effects in coadministration of 1 nM E2 in the yeast test system, while sediments from the downstream Badong and Guojiaba areas showed estrogenic activities which seemed to be more than additive (synergistic activity). There was an increasing tendency in estrogenic activity from upstream of TGR to downstream, while this tendency terminated and converted into anti-estrogenic activity in the area close to the dam. The AhR activity was detected employing rat hepatoma cell line (H4IIE). EROD activities were found homogenously distributed in sediments in TGR ranging from 200 to 311 pg 2,3,7,8-tetrachlorodibenzo-p -dioxin (TCDD) EQ g −1 dw for total AhR agonists and from 45 to 76 pg TCDD EQ g −1 dw for more persistent AhR agonists. The known AhR agonists polycyclic aromatic hydrocarbon, polychlorinated biphenyl, and PCDD/F only explained up to 8 % of the more persistent AhR agonist activity in the samples, which suggests that unidentified AhR-active compounds represented a great proportion of the TCDD EQ in sediments from TGR. These findings of estrogenic potential and dioxin-like activity in TGR sediments provide possible weight-of-evidence of potential ecotoxicological causes for the declines in fish populations which have been observed during the past decades in TGR.

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Results of the second national forest soil inventory in Germany - Interpretation of level and stock profiles for PCDD/F and PCB in terms of vegetation and humus type

Pandelova

Henkelmann

Bussian

et al. 2018

Science of The Total Environment

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Persistent aryl hydrocarbon receptor inducers increase with altitude, and estrogen-like disrupters are low in soils of the Alps

Abstract: Low bioassay responses with a higher relative amount of ER disrupters than AhR inducers were detected,indicating the higher abundance of estrogen-like than persistent dioxin-like compounds in these forested areas [corrected].

Cited by 4 publications

References 36 publications

Combined chemical and toxicological long-term monitoring for AhR agonists with SPMD-based virtual organisms in drinking water Danjiangkou Reservoir, China

Combined chemical and toxicological long-term monitoring for AhR agonists with SPMD-based virtual organisms in drinking water Danjiangkou Reservoir, China

Aryl hydrocarbon receptor (AhR) inducers and estrogen receptor (ER) activities in surface sediments of Three Gorges Reservoir, China evaluated with in vitro cell bioassays

Results of the second national forest soil inventory in Germany - Interpretation of level and stock profiles for PCDD/F and PCB in terms of vegetation and humus type

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