Persistent adenoviral infection and chronic obstructive bronchitis in children: Is there a link?

Pichler, M.; Herrmann, Gudrun; Schmidt, Hendrik; Ahrens, Peter; Zielen, Stefan

doi:10.1002/ppul.1145

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…There is also some evidence, mostly from models, that respiratory viruses are able to cause persistent infection. Persistent and/or latent AV infection was demonstrated for children with established bronchiolitis (213) but was not found in children with chronic obstructive bronchitis (256). The persistence of RV RNA was detected in the lungs of hospitalized children (153).…”

Section: Persistencementioning

confidence: 99%

Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology

2010

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SUMMARY In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy, in particular, is a time of increased disease susceptibility and severity. Early-life viral infection causes acute illness and can be associated with the development of wheezing and asthma in later life. The most commonly detected viruses are respiratory syncytial virus (RSV), rhinovirus (RV), and influenza virus. In this review we explore the complete picture from epidemiology and virology to clinical impact and immunology. Three striking aspects emerge. The first is the degree of similarity: although the infecting viruses are all different, the clinical outcome, viral evasion strategies, immune response, and long-term sequelae share many common features. The second is the interplay between the infant immune system and viral infection: the immaturity of the infant immune system alters the outcome of viral infection, but at the same time, viral infection shapes the development of the infant immune system and its future responses. Finally, both the virus and the immune response contribute to damage to the lungs and subsequent disease, and therefore, any prevention or treatment needs to address both of these factors.

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Section: Persistencementioning

confidence: 99%

Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology

2010

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“…Persistence of an adenoviral infection is described as a possible cause of non-remitting airway obstruction in children. However, chronic obstructive bronchitis with inadequate response to inhaled steroid and bronchodilator therapy is a rather rare disorder in this age group [29]. Nevertheless, adenoviral infection might act as a starter of chronic obstructive bronchitis in children [29].…”

Section: Human Adenovirus (Hadv)mentioning

confidence: 99%

“…However, chronic obstructive bronchitis with inadequate response to inhaled steroid and bronchodilator therapy is a rather rare disorder in this age group [29]. Nevertheless, adenoviral infection might act as a starter of chronic obstructive bronchitis in children [29]. Childhood infection of the respiratory tract with adenoviral agents represents an independent risk factor for the pathogenesis of COPD in cigarette smokers [26,30].…”

Section: Human Adenovirus (Hadv)mentioning

confidence: 99%

The influence of virus infections on the course of COPD

Frickmann¹,

Jungblut²,

Hirche³

et al. 2012

European Journal of Microbiology and Immunology

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Chronic obstructive pulmonary disease (COPD) is extensively influenced by viral infections. The mechanisms of how viral agents affect the pathogenesis and prognosis of COPD are numerous. In general, patients with infectious exacerbations are characterized by longer hospitalization periods and greater impairment of several lung function parameters than those with non-infectious exacerbations. Prodromal, clinical, and outcome parameters fail to distinguish virally from non-virally induced illnesses in cases of exacerbations. The importance of infections with respiratory and non-respiratory viral agents for pathogenesis and course of COPD is detailed. Human adenovirus, non-respiratory viruses including human immunodeficiency virus, human metapneumovirus, influenza virus, human rhinovirus, and respiratory syncytial virus are especially stressed.

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“…Other research suggests that adenovirus infection might predispose children to chronic obstructive brochitis. 44 Another report implicated that exacerbation of COPD might be the result of latent adenoviral infection. 45 It is clear that some viruses can have a lasting effect on the structure and function of the lung as shown in Fig 2. Interestingly, no research studies to date draw a correlation between influenza infection and the later development of respiratory disorders.…”

Section: Respiratory Viral Infection and Predisposition To Asthmamentioning

confidence: 99%

Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response

Schaller

Hogaboam

Lukacs

et al. 2006

Journal of Allergy and Clinical Immunology

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A number of investigations have linked respiratory viral infections and the intensity and subsequent exacerbation of asthma through host response mechanisms. For example, it is likely that the immune-inflammatory response to respiratory syncytial virus can cause a predisposition toward an intense inflammatory reaction associated with asthma, and adenovirus might cause exacerbation of the immune response associated with chronic obstructive pulmonary disease. In each of these situations, the host's immune response plays a critical mechanistic role through the production of certain cytokines and chemokines. Specific aspects of these augmented immune responses are determined by the biology of the virus, the genetic variability of the host, and the cytokine-chemokine phenotype of the involved tissue. For instance, the type 1/type 2 cytokine ratio in the airways during infection with rhinovirus determines how long the viral infection endures. By this same theory, it has been demonstrated that chemokine levels produced during respiratory syncytial virus infection determine host responses to later immune stimuli in the lung, with the potential to augment the asthmatic response. Further research in this area will clarify cytokines, chemokines, or cell targets, which will provide the basis for next-generation therapies.

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Persistent adenoviral infection and chronic obstructive bronchitis in children: Is there a link?

Cited by 9 publications

References 29 publications

Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology

Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology

The influence of virus infections on the course of COPD

Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response

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