Persistence of Yersinia enterocolitica in man

Hoogkamp-Korstanje, J. A. A.; Koning, J. de; Heesemann, Jürgen

doi:10.1007/bf01644307

Cited by 132 publications

(65 citation statements)

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“…Despite the importance of T lymphocytes in protection against Yersinia spp., it has been shown that this response does not always protect the host infected with Y. pseudotuberculosis or Y. enterocolitica against persistent infections [57][58][59][60]. These findings and our study suggests that Yersinia may cripple DC function to durably inactivate these responses.…”

Section: Discussionmentioning

confidence: 45%

Modulation of dendritic cell differentiation and function by YopJ of Yersinia pestis

et al. 2007

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Yersinia pestis evades immune responses in part by injecting into host immune cells several effector proteins called Yersinia outer proteins (Yops) that impair cellular function. This has been best characterized in the innate effector cells, but much less so for cells involved in adaptive immune responses. Dendritic cells (DC) sit at the crossroads between innate and adaptive immunity, and can function to initiate or inhibit adaptive immune responses. Although Y. pestis can target and inactivate DC, the mechanism responsible for this remains unclear. We have found that injection of Y. pestis YopJ into DC progenitors disrupts key signal transduction pathways and interferes with DC differentiation and subsequent function. YopJ injection prevents upregulation of the NF-jB transcription factor Rel B and inhibits MAPK/ERK activationboth having key roles in DC differentiation. Furthermore, YopJ injection prevents costimulatory ligand up-regulation, LPS-induced cytokine expression, and yields differentiated DC with diminished capability to induce T cell proliferation and IFN-c induction. By modulating DC function through YopJ-mediated disruption of signaling pathways during progenitor to DC differentiation, Yersinia may interfere with the adaptive responses necessary to clear the infection as well as establish a tolerant immune environment that leads to chronic infection/carrier state in the surviving host.

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Section: Discussionmentioning

confidence: 45%

Modulation of dendritic cell differentiation and function by YopJ of Yersinia pestis

et al. 2007

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“…Comparing the agglutination reaction with determination of specific anti-IgA and anti-IgG to Yops in culture-positive patients, it was clear that the anti-Yops are far more sensitive and reliable for diagnosis of Yersinia-associated disease. This was previously shown.6,7> 14,15 We could not associate the systemic forms with predisposing factors such as malignancy, hematologic disorders and iron overload. 16 We were impressed by the severity of the lymphad enopathy, which resembled that of disorders such as malignant lymphoma.…”

Section: Discussionmentioning

confidence: 50%

“…Persis tence of infection and antigens may be responsible for or involved in these complications. 15 Antibiotic treatment does not influence the course and duration of uncomplicated enteritis,14,18 and cur rently we do not advise antibiotic treatment in children younger than 6 years of age with enteritis in our area.…”

Section: Discussionmentioning

confidence: 78%

Yersinia enterocolitica infection in children

Hoogkamp-Korstanje

Stolk-Engelaar

1995

The Pediatric Infectious Disease Journal

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The clinical presentation, course and outcome of Yersinia enterocolitica infection was studied prospectively in 125 children. Enteric forms oc curred in 114 children (92 enteritis, 20 pseudoap pendicitis, 2 chronic ileitis), of whom 17 also had extramesenteric manifestations; 11 children had one or more extramesenteric forms without en teric disease. Enteritis occurred more frequently in young children whereas serious forms and extramesenteric forms were more common in children older than 6 years of age (P < 0.001). Arthritis was observed in 13 children and exten sive lymphadenopathy in 11; 1 child had septice mia with pleurisy, 1 had vasculitis, 1 had chole cystitis and 4 had erythema nodosum. Diagnosis was established by positive culture in 100 (80%) children and by agglutinin test in 11 of 45 (24%), demonstration of circulating specific anti-IgA and anti-IgG to Yersinia outer membrane pro teins in 47 of 48 (98%) and detection of antigen in biopsies in 28 of 33 (85%) children. The 2 latter methods were superior to the agglutinin test. Serotype 03 and 0 9 predominated. The fre quency and seriousness of complications may justify the use of antibiotics for Yersinia enteritis in children 6 years of age or older.

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“…Diagnosis is not easy because the disease has diverse clinical presentations and stool cultures require specific laboratory methods, most of which are not per formed routinely. Furthermore, stool cultures and serology by demonstration of circulating agglutinins are often nega tive in the more complicated forms (2,3), and both may contribute to underestimation of the disease, In 1982 we began a study on Yersinia infections. At first all patients with enteritis were cultured for Y. enterocolitica and their physicians were asked to record all symptoms in cases with positive culture.…”

Section: Introductionmentioning

confidence: 99%