Persistence of Spatial Memory Induced by Spaced Training Involves a Behavioral-Tagging Process

Correa, Julieta; Tintorelli, Ramiro; Budriesi, Pablo; Viola, Haydeé

doi:10.1016/j.neuroscience.2022.02.032

Cited by 6 publications

(4 citation statements)

References 69 publications

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“…Most of them focused on understanding the effects of reconsolidation on established memories and showed, in different cases, that the sole reactivation could serve as a memory enhancer. This type of effect was found in rodents and humans 32 – 37 . Instead of focusing on the effect of reconsolidation on memory, we studied how experiences occurring close to a reactivating event act on the reconsolidation process to affect previously stored memories.…”

Section: Discussionmentioning

confidence: 52%

Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change

Schroeder,

Fullio,

Ballarini

et al. 2023

Commun Biol

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Reconsolidation turns memories into a responsive state that allows their modulation until they stabilize again. This phenomenon attracted remarkable attention due to its potential impact on therapeutics and education. Recent evidence revealed that different memories undergo reconsolidation via a behavioral tagging process. Thus, their re-stabilization involves setting “reconsolidation-tags” and synthesizing plasticity-related proteins for their capture at the tagged sites. Here, we studied the possibility of affecting these fundamental mechanisms to modulate reconsolidation. Our findings, in laboratory rats, indicate that exploring a novel environment 60 min before or after memory reactivation improves spatial object recognition memory by promoting protein synthesis. Conversely, experiencing novelty immediately after reactivation impairs the reconsolidation by affecting the tags. Similar effects, but with a different optimal time window for improvement, occur in inhibitory avoidance memory. These results highlight the possibility of modulating existing memories using non-invasive interventions that selectively affect the fundamental mechanisms of behavioral tagging during their reconsolidation.

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Section: Discussionmentioning

confidence: 52%

Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change

Schroeder,

Fullio,

Ballarini

et al. 2023

Commun Biol

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“…This exposure time does not lead to a 24-h LTM (SOR-LTM), because animals replaced in the arena in which one of the objects was displaced to a novel location do not allocate more time exploring the displaced object, 10 , 31 as they typically do when SOR-LTM is present. 30 …”

Section: Resultsmentioning

confidence: 99%

“…The BT mechanism has been demonstrated for a broad spectrum of memory types, animal species, and ages of individuals. 8 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 PRPs can be provided by either novel events, 6 , 17 , 20 , 21 , 22 , 23 , 24 reactivation or extinction sessions, 25 , 26 rewarding events, 27 exposure to acute stress, 28 , 29 memory expression of enough similar experiences 30 or retraining sessions. 31 To what extent BT provides a valid framework to understand LTM formation on repeated aversive spaced training trials remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

A behavioral tagging account of kinase contribution to memory formation after spaced aversive training

Budriesi¹,

Tintorelli²,

Correa³

et al. 2023

iScience

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“…Studies showed that intra-hippocampal infusion of emetine after memory reactivation has been shown to impair the reconsolidation of certain memories. It disrupts the process by which memories are stabilized after retrieval, leading to memory impairment ( Correa et al, 2022 ). Emetine’s ability to interfere with memory reconsolidation raises potential therapeutic applications in memory-related disorders.…”

Section: Discussionmentioning

confidence: 99%

Exploring gene-drug interactions for personalized treatment of post-traumatic stress disorder

Skolariki,

Vlamos

2024

Front. Comput. Neurosci.

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IntroductionPost-Traumatic Stress Disorder (PTSD) is a mental disorder that can develop after experiencing traumatic events. The aim of this work is to explore the role of genes and genetic variations in the development and progression of PTSD.MethodsThrough three methodological approaches, 122 genes and 184 Single Nucleotide Polymorphisms (SNPs) associated with PTSD were compiled into a single gene repository for PTSD. Using PharmGKB and DrugTargetor, 323 drug candidates were identified to target these 122 genes. The top 17 drug candidates were selected based on the statistical significance of the genetic associations, and their promiscuity (number of associated genestargets) and were further assessed for their suitability in terms of bioavailability and drug-like characteristics. Through functional analysis, insights were gained into the biological processes, cellular components, and molecular functions involved in PTSD. This formed the foundation for the next aspect of this study which was to propose an efficient treatment for PTSD by exploring drug repurposing methods.ResultsThe main aim was to identify the drugs with the most favorable profile that can be used as a pharmacological approach for PTSD treatment. More in particular, according to the genetic variations present in each individual, the relevant biological pathway can be identified, and the drug candidate proposed will specifically target said pathway, accounting for the personalized aspect of this work. The results showed that the drugs used as off-label treatment for PTSD have favorable pharmacokinetic profiles and the potential drug candidates that arose from DrugTargetor were not very promising. Clozapine showed a promising pharmacokinetic profile and has been linked with decreased psychiatric symptoms. Ambrucin also showed a promising pharmacokinetic profile but has been mostly linked with cancer treatment.

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Persistence of Spatial Memory Induced by Spaced Training Involves a Behavioral-Tagging Process

Cited by 6 publications

References 69 publications

Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change

Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change

A behavioral tagging account of kinase contribution to memory formation after spaced aversive training

Exploring gene-drug interactions for personalized treatment of post-traumatic stress disorder

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