Persistence of secondary mitral regurgitation and response to cardiac resynchronization therapy

Abstract

CRT can reduce moderate or severe baseline MR to non-significant in one-third of patients. However, its persistence was associated with worse clinical evolution, greater incidence of arrhythmic events, and less reverse remodelling.

Assessing mitral regurgitation in the prediction of clinical outcome after cardiac resynchronization therapy

“…In contrast, in a large observational registry by van Bommel et al, 23 baseline MR remained a significant predictor of unplanned HF hospitalization and mortality in univariate and multivariate modeling. A similar investigation by CabreraBueno et al 24 found that MR persistence after CRT was also associated with an increased incidence of arrhythmic events. Our findings amplify and extend these results.…”

Impact of Cardiac Resynchronization Therapy on Heart Failure Patients: Experience from One Center

“…Further investigations are warranted to combine CRT with specific MR therapeutic approaches such as surgical annuloplasty or percutaneous therapies to maximize the effect of CRT in MR patients [17].…”

Novel Heart Failure Biomarkers Predict Improvement of Mitral Regurgitation in Patients Receiving Cardiac Resynchronization Therapy—The BIOCRT Study

“…Functional MR in HF is clearly related to adverse prognosis, but the treatment of this condition remains elusive. CRT for eligible patients emerges as a possible solution: significant MR reduction has been shown for a subset of patients in previous and current data (4, 6, 21-23). Since surgical or catheter treatment of secondary MR can sometime be considered in selected patients, identification of those likely or unlikely to improve their MR after CRT becomes clinically relevant.…”