Persistence of SARS-CoV-2 virus RNA in feces: A case series of children

Du, Wenjun; Jin-hong, YU; Liu, Xiaoyan; Chen, Hong; Lin, Lingbo; Li, Qiang

doi:10.1016/j.jiph.2020.05.025

Cited by 38 publications

(33 citation statements)

References 9 publications

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“…In addition, we found that a shared latrine was the most likely cause of incident SARS-CoV-2 contagion among several members of two otherwise unrelated families [27]. These findings are in line with previous studies that demonstrated the presence of the virus in human feces [28,29] as well as in rivers contaminated by wastewater [30]. However, we cannot rule out the possibility that latrines are acting as a proxy for unknown interacting variables.…”

Section: Discussionsupporting

confidence: 83%

Late incidence of SARS-CoV-2 infection in a highly-endemic remote rural village. A prospective population-based cohort study

Brutto

Costa²,

Mera

et al. 2020

Pathogens and Global Health

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Data on SARS-CoV-2 transmission in rural communities is scarce or non-existent. A previous cross-sectional study in middle-aged and older adults enrolled in the Atahualpa Project Cohort demonstrated that 45% of participants had SARS-CoV-2 antibodies, 77% of whom were symptomatic. Here, we assessed the incidence of SARS-CoV-2 infection in the abovementioned rural population. One month after baseline testing, 362 of 370 initially seronegative individuals were re-tested to assess incidence of seroconversion and associated risk factors. Twenty-eight of them (7.7%) became seropositive. The overall incidence rate ratio was 7.4 per 100 person months of potential virus exposure (95% C.I.: 4.7-10.2). Six seroconverted individuals (21.4%) developed SARS-CoV-2-related symptomatology. The only covariate significantly associated with seroconversion was the use of an open latrine. Predictive margins showed that these individuals were 2.5 times more likely to be infected (95% C.I.: 1.03-6.1) than those using a flushing toilet. Therefore, along one month, approximately 8% of seronegative individuals became infected, even after almost half of the population was already seropositive. Nevertheless, a smaller proportion of incident cases were symptomatic (21% versus 77% of the earlier cases), and no deaths were recorded. Whether this decreased clinical expression resulted from a lower viral load in new infections cannot be determined. Increased seroconversion in individuals using latrines is consistent with a contributory role of fecal-oral transmission, although we cannot rule out the possibility that latrines are acting as a proxy for poverty or other unknown interacting variables.

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Section: Discussionsupporting

confidence: 83%

Late incidence of SARS-CoV-2 infection in a highly-endemic remote rural village. A prospective population-based cohort study

Brutto

Costa²,

Mera

et al. 2020

Pathogens and Global Health

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“…Cough: Initial symptoms were fever and cough; even among neonates 30 . Cough was experienced by the majority of patients, 10‐12,14,15,19,21‐93 it was mainly dry, but was sometimes followed by productive cough in moderately severe cases 19 . There may be upper airway symptoms, such as nasal congestion, rhinitis, and sore throat 19 .…”

Section: Resultsmentioning

confidence: 99%

“…Fever: One of the commonest early symptoms is fever, 11,14,15,19‐22,25‐36,38‐58,61‐65,67,68,70‐106 occasionally low grade. In Zhejiang province, fever clinics that exclusively accept for admission patients suspected of being positive for SARS‐CoV‐2 were set up 27 …”

Section: Resultsmentioning

confidence: 99%

Coronavirus global pandemic: An overview of current findings among pediatric patients

Perikleous

Tsalkidis

Bush

et al. 2020

Pediatric Pulmonology

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Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) epidemic has been emerged as a cardinal public health problem. Children have their own specific clinical features; notably, they seem to be escaping the severe respiratory adverse effects. The international scientific community is rapidly carrying out studies, driving to the need to reassess knowledge of the disease and therapeutic strategies. Aim To assess the characteristics of COVID‐19 infected children worldwide of all ages, from neonates to children and adolescents, and how they differ from their adult counterparts. Search Strategy An electronic search in PubMed was conducted, using combinations of the following keywords: coronavirus, SARS‐CoV‐2, COVID‐19, children. The search included all types of articles written in English between January 1, 2019 until August 15, 2020. Results The search identified 266 relevant articles. Children were mainly within family clusters of cases and have relatively milder clinical presentation compared with adults; children were reported to have better outcomes with a significantly lower mortality rate. Cough and fever were the most common symptoms while pneumonia was the cardinal respiratory manifestation of infected children. Laboratory results and thoracic imaging give varying results. Conclusions Children were mainly family cluster cases and usually presented with a mild infection, although cases presented with the multisystem inflammatory syndrome are becoming more apparent. Studies determining why the manifestations of SARS‐CoV‐2 infection are so variable may help to gain a better understanding of the disease and accelerate the development of vaccines and therapies.

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“…[9] Although in our locality, 4 children suffered from such a predicament, cumulatively from our literature review, the number of children who have prolonged faecal excretion and potential spread of infection of SARS-CoV-2 by this route is approximately 150-200 in total. [7,8,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Therefore, this issue is a huge concern affecting many patients and deserves further deliberation.…”

Section: Discussionmentioning

confidence: 99%

Discharging coronavirus disease 2019 (COVID-19) patients with faecal viral shedding and prolonged hospitalisation

Duque

Mak²,

Wong³

et al. 2020

JHA

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Persistence of SARS-CoV-2 virus RNA in feces: A case series of children

Cited by 38 publications

References 9 publications

Late incidence of SARS-CoV-2 infection in a highly-endemic remote rural village. A prospective population-based cohort study

Late incidence of SARS-CoV-2 infection in a highly-endemic remote rural village. A prospective population-based cohort study

Coronavirus global pandemic: An overview of current findings among pediatric patients

Discharging coronavirus disease 2019 (COVID-19) patients with faecal viral shedding and prolonged hospitalisation

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