“…Recent studies have demonstrated that high-frequency transthoracic echocardiography can detect significant stenosis of the LITA graft by evaluating the ratio of the diastolic-to-systolic velocity or the diastolic fraction of the LITA graft flow; [4][5][6] however, the flow pattern is influenced by other factors, such as the site of measurement within the LITA graft, the persistence of the branches of the LITA, the degree of stenosis in the native coronary artery and the regional wall motion of the left ventricle. 6,[11][12][13][14] In addition, the diastolic fraction of the LITA graft flow cannot distinguish mild or intermediate graft stenosis. Measuring flow reserve after drug administration or exercise is a useful method of evaluating the LITA graft stenosis that could not be detected by the LITA graft flow pattern at rest, but measuring the flow reserve may complicate a routine examination.…”