Persistence of impaired health status of Q fever patients 4 years after the first Dutch outbreak

Limonard, Gijs; Peters, Jeannette B.; Besselink, R.; Groot, C. A. R.; Dekhuijzen, P.N.R.; Vercoulen, J.H.M.M.; Nabuurs-Franssen, Marrigje H.

doi:10.1017/s0950268815002216

Cited by 13 publications

(15 citation statements)

References 27 publications

(39 reference statements)

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“…In these studies, patients with possible, probable, or proven "chronic Q fever" were excluded. Limonard et al investigated the health status of 82 patients with a past primary infection at 1 and 4 years of follow-up and found a higher frequency of severely impaired general quality of life and undue fatigue (50% and 46%, respectively) than in an adjusted control group (645,646). These proportions were stable through the years.…”

Section: Other Related Clinical Syndromesmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Other Related Clinical Syndromesmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…These studies confirmed that Q-fever had a significant impact on the level of fatigue and QoL measured in the first 3 months up to 26 months after onset of Q-fever compared to either controls or normative data [ 11 – 16 ]. Studies also showed that Q-fever patients still experienced a significant impact on fatigue and QoL 4 years after onset of Q-fever compared to normative data or a healthy control group [ 14 , 18 ]. Other studies showed significant improvements over time after a follow-up of 24 months and even absence of significant differences on the level of fatigue and QoL between persons with or without a history of C .…”

Section: Introductionmentioning

confidence: 99%

Impact of Q-fever on physical and psychosocial functioning until 8 years after Coxiella burnetii infection: An integrative data analysis

Reukers¹,

Jaarsveld²,

Akkermans³

et al. 2022

PLoS ONE

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Background This study aimed to determine short- and long-term physical and psychosocial impact of Coxiella burnetii infection in three distinct entities: Q-fever fatigue syndrome (QFS), chronic Q-fever, and patients with past acute Q-fever without QFS or chronic Q-fever. Methods Integrative data analysis was performed, combining original data from eight studies measuring quality of life (QoL), fatigue, physical and social functioning with identical validated questionnaires, from three months to eight years after onset infection. Linear trends in each outcome were compared between Q-fever groups using multilevel linear regression analyses to account for repeated measures within patients. Results Data included 3947 observations of 2313 individual patients (228 QFS, 135 chronic Q-fever and 1950 patients with past acute Q-fever). In the first years following infection, physical and psychosocial impact was highest among QFS patients, and remained high without significant improvements over time. In chronic Q-fever patients, QoL and physical functioning worsened significantly over time. Levels of fatigue and social participation in patients with past acute Q-fever improved significantly over time. Conclusion The impact differs greatly between the three Q-fever groups. It is important that physicians are aware of these differences, in order to provide relevant care for each patient group.

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“…Cardiovascular disease are long-term sequelae (Parker, NR, Barralet & Bell 2006) and myocarditis is the leading cause of death in humans (Fournier, Pierre-Edouard et al 2001). Four years after the initial Q fever infection, chronic fatigue syndrome (CFS) was found in 46% Q fever patients from the 2007 Q fever outbreak (Limonard et al 2016).…”

Section: List Of Figures and Tablesmentioning

confidence: 99%

The epidemiology of Q fever in Queensland, Australia and effectiveness of vaccination for prevention

Woldeyohannes¹

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Q fever, caused by the small obligate intracellular, gram-negative pathogenic bacterium Coxiella burnetii, is primarily an occupationally-acquired zoonotic disease most commonly reported in people working in the livestock and meat industries who have direct or indirect contact with infected animals. The main preventive tool for Q fever is a vaccine (Q-VAX ® , Seqirus, Australia) that is recognised to be highly effective and providing long lasting protection. Its implementation requires pre-vaccination screening tests using serology and skin tests conducted in parallel. This is because the vaccine has more side effects in persons who have already had the disease Q fever, so testing for prior immunity is necessary before vaccination to avoid unwanted vaccine side effects. However, outbreaks of Q fever continue to be recorded in abattoirs and Q fever continues to be an important public health issue in Australia. The incidence of Q fever remains high especially in Queensland and New South Wales (NSW) though there is good evidence of improved Q fever control as a result of the implementation of the Q fever vaccination program. There is evidence that the Q fever vaccination has not been fully implemented because of the high incidence of Q fever among individuals targeted by past vaccination program.Therefore, this PhD thesis was mainly intended to assess the overall effectiveness of the Q fever vaccination program, and the associated Q fever notification and hospital admission rates, and the most risky exposures for the occurrence of Q fever in Queensland, Australia. Chapter 1 presents a literature review on Q fever at global and Australia levels. In chapter 2, I conducted a systematic review and meta-analysis on the seroprevalence of Q fever. Chapter 3 addresses estimation of vaccine failure rate and duration of immunity for Q fever using Cox proportional hazard model. I then explicitly addressed the accuracy of the Q fever pre-screening test using Bayesian latent class analysis in chapter 4. In chapter 5, I assessed the demographic and vaccination status factors associated with the incidence of Q fever infection using a case control design. In chapter 6, I modelled the rate of Q fever notification and hospitalization, and identified the associated factors using Poisson and Negative Binomial regression models. In chapter 7, I conducted a risk assessment using the enhanced Q fever exposure surveillance data using multiple correspondence analysis (MCA) technique. Finally, chapter eight highlight key findings, discuss them, and summarize the thesis.In summary, the results presented in this Thesis, address the knowledge gap regarding the incidence of Q fever in vaccinated individuals and the duration of immunity of the Q fever vaccine and the accuracy of the prescreening tests thereby addressing the overall effectiveness of the Q fever vaccination program and the resulting Q fever notification and admission rates in the Queensland. It presents evidence of the protective effect of being vaccinated using the Q fever vaccine...

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Persistence of impaired health status of Q fever patients 4 years after the first Dutch outbreak

Cited by 13 publications

References 27 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

Impact of Q-fever on physical and psychosocial functioning until 8 years after Coxiella burnetii infection: An integrative data analysis

The epidemiology of Q fever in Queensland, Australia and effectiveness of vaccination for prevention

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