Persistence of anti-HBs 5 years after the introduction of routine infant and adolescent vaccination in Italy

Faustini, Annunziata; Franco, Elisabetta; Sangalli, M; Spadea, Teresa; Calabrese, R.; Cauletti, M.; Perucci, Carlo A.

doi:10.1016/s0264-410x(01)00005-6

Cited by 18 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 Our study results support previous observations regarding the exponential decay of antibodies, with the half-life increasing with time since vaccination. 8,15,16 Additionally, the similar 56-fold decrease of anti-HBs GMTs observed five and ten years post-vaccination suggests a plateau-effect five years after vaccinating pre-adolescents. The ongoing follow-up of subjects allocated to Group C will show if this plateau-effect is longlasting.…”

Section: Resultsmentioning

confidence: 83%

Antibody and immune memory persistence after vaccination of preadolescents with low doses of recombinant hepatitis B vaccine

Gîlca¹,

Serres²,

Boulianne³

et al. 2010

Human Vaccines

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 83%

Antibody and immune memory persistence after vaccination of preadolescents with low doses of recombinant hepatitis B vaccine

Gîlca¹,

Serres²,

Boulianne³

et al. 2010

Human Vaccines

View full text Add to dashboard Cite

“…It was found that 92.9% of children and 94.1% of teenagers were protected against HBV (anti-HB titer >10 mIU/mL). In adolescents, the antibody levels were much higher than in children [46].…”

Section: Discussionmentioning

confidence: 99%

Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination

Coppeta

Pompei

Balbi

et al. 2019

IJERPH

View full text Add to dashboard Cite

Background: Immunization of healthcare workers (HCWs) and medical students for the hepatitis B virus (HBV) is a crucial part of the hospital infection control programs. The aim of our study was to evaluate the persistence of anti-HBV specific antibodies in HCWs vaccinated during infancy or adolescence. Methods: Medical records of 734 consecutive subjects born after 1980 (481 females, 65.5% and 253 males, 34.5%) who underwent serological testing for anti-hepatitis B surface antibodies (anti-HBs) were evaluated. Results: A non-protective titer (<10 mUI) was found in 88/734 (12.0%) subjects; 84 (47.8%) of them received a booster dose of anti-hepatitis B vaccine and the anti-HBs titer of 58 subjects was measured 1 month after administration. A protective titer (anti-HBs >10 mIU/mL) was observed in almost 90% of subjects receiving the booster dose. Conclusions: A substantial percentage of HCWs had a non-protective anti-HBs titer at the time of the first employment, especially those vaccinated at birth age. However, the response to the booster dose showed that in these subjects, an anti-HBs titer <10 mIU/mL was due to the physiological decline of antibodies over the years. Therefore, primary immunization in childhood is highly effective and provides lasting immunity against HBV infection.

show abstract

“…None had anti-HBs Ͻ10 mIU/mL. Faustini et al 19 followed children at low risk who were vaccinated in infancy with a recombinant vaccine. By 5 years of age, only 7% had titers of anti-HBs Ͻ10 mIU/mL.…”

Section: Discussionmentioning

confidence: 99%

Duration of Hepatitis B Immunity in Low Risk Children Receiving Hepatitis B Vaccinations From Birth

Petersen

Bulkow²,

McMahon³

et al. 2004

The Pediatric Infectious Disease Journal

115

View full text Add to dashboard Cite

show abstract

Persistence of anti-HBs 5 years after the introduction of routine infant and adolescent vaccination in Italy

Cited by 18 publications

References 32 publications

Antibody and immune memory persistence after vaccination of preadolescents with low doses of recombinant hepatitis B vaccine

Antibody and immune memory persistence after vaccination of preadolescents with low doses of recombinant hepatitis B vaccine

Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination

Duration of Hepatitis B Immunity in Low Risk Children Receiving Hepatitis B Vaccinations From Birth

Contact Info

Product

Resources

About