“…Chlorantraniliprole was the first commercialized diamide and exhibits an exceptional activity against lepidopteran pests ( European Food Safety Authority et al, 2019 ; Kadala et al, 2019 ; Zhou et al, 2019 ; Jouraku et al, 2020 ; Satpathy et al, 2020 ). It activates ryanodine receptors by stimulation of calcium release from the sarcoplasmic reticulum of muscle cells causing impaired regulation, paralysis, and ultimately death of target species ( Ahlawat et al, 2019 ; Chen et al, 2019 ; He et al, 2019 ; Héma et al, 2019 ; Jallow et al, 2019 ; Plata-Rueda et al, 2019 ; Silva et al, 2019 ; Passos et al, 2020 ; Shah and Shad, 2020 ; Williams et al, 2020 ). However, the researcher continued to pursue a wide range of polar groups on the anthranilic core with an emphasis on nitrile substitution ( Barrania, 2019 ; Bolzan et al, 2019 ; Carscallen et al, 2019 ; Mao et al, 2019 ; Gao et al, 2019 ; Meng et al, 2019 ; O'Neal et al, 2019 ; Sharma et al, 2019 ; Sreedhar, 2019 ; Truong and Pessah, 2019 ; Jiang et al, 2020 ).…”