Persistence and clearance of human papillomavirus infection: a prospective cohort study

Rosa, Maria Inês da; Fachel, J. M G; Rosa, Daniela D.; Medeiros, Lídia Rosi; Igansi, Cristine Nascente; Bozzetti, Mary Clarisse

doi:10.1016/j.ajog.2008.06.033

Cited by 58 publications

(66 citation statements)

References 40 publications

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“…The majority of HPV infected patients are able to clear the infection naturally, and only a small proportion will progress to SCC (Sudenga et al, 2014). The most important protective immune mechanism is the suppression or elimination of the HPV virus and the immune response mediated by cells within 1-2 years of exposure (Rosa et al, 2008). A persistent infection of the HR-HPV genotypes is considered the most important factor for the development of cervical lesions and progression to SCC; however, it is not a sufficient cause (Sudenga et al, 2014).…”

Section: Scc Burden Among Brazilian Womenmentioning

confidence: 99%

“…A persistent infection of the HR-HPV genotypes is considered the most important factor for the development of cervical lesions and progression to SCC; however, it is not a sufficient cause (Sudenga et al, 2014). There are other factors that can contribute to the emergence and progression of the lesion, for example, high viral load, number of pregnancies, use of oral contraceptives, smoking, immunosuppression, other STD infections and genetic predisposition (Rosa et al, 2008).…”

Section: Scc Burden Among Brazilian Womenmentioning

confidence: 99%

See 1 more Smart Citation

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

Freitas

Suehiro²,

Consolaro³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Human papillomavirus is a virus that is distributed worldwide, and persistent infection with high-risk genotypes (HR-HPV) is considered the most important factor for the development of squamous cell cervical carcinoma (SCC). However, by itself, it is not sufficient, and other factors may contribute to the onset and progression of lesions. For example, infection with other sexually transmitted diseases such as human immunodeficiency virus (HIV) may be a factor. Previous studies have shown the relationship between HPV infection and SCC development among HIV-infected women in many regions of the world, with great emphasis on low-and middleincome countries (LMICs). Brazil is considered a LMIC and has great disparities across different regions. The purpose of this review was to highlight the current knowledge about HPV infection and cervical abnormalities in HIV+ women in Brazil because this country is an ideal setting to evaluate HIV impact on SCC development and serves as model of LMICs and low-resource settings.

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Section: Scc Burden Among Brazilian Womenmentioning

confidence: 99%

Section: Scc Burden Among Brazilian Womenmentioning

confidence: 99%

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

Freitas

Suehiro²,

Consolaro³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…The high-risk HPV DNA test is highly sensitive but low specific (Rodríguez et al, 2008;Rosa et al, 2008), and is not effective for distinguishing HPV physical status (episomal or integrated infection). Therefore, it is incapable of identifying which part of patients with the ASCUS or HPV-positive results are likely to have a CIN2+ lesion (Arbyn et al, 2004, Poomtavorn et al, 2011.…”

Section: Discussionmentioning

confidence: 99%

Significance of Human Telomerase RNA Gene Amplification Detection for Cervical Cancer Screening

Chen

Lin²,

Liu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: Liquid-based cytology is the most often used method for cervical cancer screening, but it is relatively insensitive and frequently gives equivocal results. Used as a complementary procedure, the high-risk human papillomavirus (HPV) DNA test is highly sensitive but not very specific. The human telomerase RNA gene (TERC) is the most often amplified oncogene that is observed in cervical precancerous lesions. We assessed genomic amplification of TERC in liquid-based cytological specimens to explore the optimal strategy of using this for cervical cancer screening. Methods: Six hundred and seventy-one residual cytological specimens were obtained from outpatients aged 25 to 64 years. The specimens were evaluated by the Digene Hybrid Capture 2 (HC2) HPV DNA test and fluorescence in situ hybridization (FISH) with a chromosome probe to TERC (3q26). Colposcopic examination and histological evaluation were performed where indicated. Results: The TERC positive rate was higher in the CIN2+ (CIN2, CIN3 and SCC) group than in the normal and CIN 1 groups (90.0% vs. 10.4%, p < 0.01). In comparison with the HC2 HPV DNA test, the TERC amplification test had lower sensitivity but higher specificity (90.0% vs. 100.0%, 89.6% vs. 44.0%, respectively). TERC amplification test used in conjunction with the HC2 HPV DNA test showed a combination of 90.0% sensitivity and 92.2% specificity. Conclusion: The TERC amplification test can be used to diagnose cervical precancerous lesions. TERC and HPV DNA co-testing shows an optimal combination of sensitivity and specificity for cervical cancer screening.

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“…The results of the current study are consistent with those of other studies regarding HPV detection in Brazilian women. de Aguiar Original Article et al, 25 Lorenzi et al, 19 Rosa et al, 26 and Nonnenmacher et al 27 reported HPV prevalence rates of 10.5%, 12.3%, 12.3%, and 15%, respectively. The majority of these women lived in rural or remote areas of Brazil and experienced difficulties in accessing medical care or the heath assistance infrastructure.…”

Section: Discussionmentioning

confidence: 99%

Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas?

Lorenzi

Fregnani

Possati-Resende

et al. 2016

Cancer Cytopathology

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Persistence and clearance of human papillomavirus infection: a prospective cohort study

Cited by 58 publications

References 40 publications

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

Significance of Human Telomerase RNA Gene Amplification Detection for Cervical Cancer Screening

Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas?

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