Persistence and Adherence to Biologic Therapies in Juvenile Idiopathic Arthritis

Abstract

BackgroundJuvenile Idiopathic Arthritis (JIA) is a chronic inflammatory disease that often requires the use of biological therapies to control disease activity. Persistence and adherence to treatment are important aspects on which we have scarce information.MethodsWe performed a longitudinal, retrospective, and observational study based on daily clinical management of JIA patients. We calculated the clinical remission status at 6 and 12 months. Persistence of biological therapy was evaluated by Kaplan-Meier curves and adherence by the Medication Possession Ratio (MPR).ResultsWe included 68 patients who received biological therapy. Of these, 11 (16.2%) and 5 (7.4%) required a second and third biological, respectively. Persistence rate of biological therapies at 5 years was 64%, with no differences between the first and second biological line. Adherence was high the first year of treatment (MPR80: 96.3%) as well as the second and third years (MPR80: 85.2% and 91.8% respectively).ConclusionsPersistence and adherence to biological therapies were remarkably high in our JIA cohort. Adherence to biological treatments could be related to a higher probability of accomplishing Wallace remission criteria at 6 months, but it was not confirmed at 12 months.

Síndrome de Sjögren en un adolescente. Caso Clínico

“…Aunque el cintigrama está catalogado como método secundario para diagnóstico, revisiones sistemáticas muestran un rendimiento que oscila entre 47 a 88% de sensibilidad y 50 a 89% de especificidad 5,18 , que sumado a sus características (no invasivo, fácil de realizar, bajo costo) lo postulan como una excelente herramienta (no aislada) para llevar a cabo el dictamen. Incluso, en revisiones recientes se ha propuesto la ecografía como herramienta diagnóstica, ya que además de ser accesible y no cruenta, tiene una sensibilidad de hasta 90% para detectar alteraciones glandulares características de la enfermedad 23 .…”