Perseverative behavior in Alzheimer's disease and subcortical ischemic vascular dementia.

Lamar, Melissa; Podell, Kenneth; Carew, Tania Giovannetti; Cloud, Blaine S.; Resh, Robynn; Kennedy, Colleen M.; Goldberg, Elkohnon; Kaplan, Edith; Libon, David J.

doi:10.1037/0894-4105.11.4.523

Cited by 90 publications

(65 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased number of perseverations on semantic fluency (recurrent perseverations) in AD suggests distinct patterns of perseverative behaviour in these disorders in agreement with a previous report of comparable populations [33]. Our findings are consistent with the hypothesis of perseverations proposed by Sandson and Albert [34].…”

Section: Discussionsupporting

confidence: 83%

Neuropsychological Deficit in Early Subcortical Vascular Dementia: Comparison to Alzheimer’s Disease

Traykov

Baudic

Thibaudet

et al. 2002

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

To further clarify the cognitive syndrome in subcortical vascular dementia (VaD), we investigated 20 patients with early-stage VaD as compared with 30 patients with Alzheimer’s disease (AD) and 22 normal controls using episodic memory, attention/executive function and language tests. The patient groups were closely matched in terms of age, education and severity of dementia. The VaD patients had a significantly better free recall, cued recall and recognition memory than AD patients, the recognition being within normal limits in VaD. In addition, VaD patients had a greater number of perseverative errors during the Modified Card Sorting test, while AD patients exhibited more perseverations of semantic fluency. The results of retrieval deficit syndrome and increased number of perseverations during tasks sensitive to frontal lobe function are in agreement with the studies emphasizing the importance of frontal dysfunction in subcortical VaD. These findings are relevant for the early diagnosis of VaD and might be useful in the differential diagnosis with AD.

show abstract

Section: Discussionsupporting

confidence: 83%

Neuropsychological Deficit in Early Subcortical Vascular Dementia: Comparison to Alzheimer’s Disease

Traykov

Baudic

Thibaudet

et al. 2002

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…A first study specifically comparing graphic perseverations in patients with AD or VaD showed that perseverations were more frequent in VaD than in AD [172]. However, Cosentino et al [173] assessed patients on CDT and on copying clocks and observed that perseveration and closing-in (see below) in AD and VaD were more frequent in patients with higher number of white matter lesions and with more marked impairment on executive frontal tasks.…”

Section: Graphic Perseverationmentioning

confidence: 99%

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

View full text Add to dashboard Cite

Abstract. Drawing is a multicomponential process that can be impaired by many kinds of brain lesions. Drawing disorders are very common in Alzheimer's disease and other forms of dementia, and can provide clinical information for the distinction of the different dementing diseases. In our review we started from an overview of the neural and cognitive bases of drawing, and from a recollection of the drawing tasks more frequently used for assessing individuals with dementia. Then, we analyzed drawing disorders in dementia, paying special attention to those observed in Alzheimer's disease, from the prodromal stages of the amnesic mild cognitive impairment to the stages of full-blown dementia, both in the sporadic forms with late onset in the entorhino-hippocampal structures and in those with early onset in the posterior neocortical structures. We reviewed the drawing features that could differentiate Alzheimer's disease from vascular dementia and from the most frequent forms of degenerative dementia, namely frontotemporal dementia and Lewy body disease. Finally, we examined some peculiar aspects of drawing disorders in dementia, such as perseverations, rotations, and closing-in. We argue that a careful analysis of drawing errors helps to differentiate the different forms of dementia more than overall accuracy in drawing.

show abstract

“…number of categories on the Wisconsin Card Sorting Test and performance on Raven's Colored Progressive Matrices). Moreover, Lamar et al [19] reported a pattern of perseverative behavior in s-IVD patients different from that of AD patients. In line with the assumption that conventional neuropsychological tests might fail to distinguish between cortical and subcortical dementia, Mendez and Mendez [20] suggested unstructured tasks that require executive abilities such as behavioral initiation as the most useful to better differentiate VaD from AD patients.…”

Section: Introductionmentioning

confidence: 99%

Frontal Impairment in Subcortical Ischemic Vascular Dementia in Comparison to Alzheimer’s Disease

Cannatà¹,

Alberoni

Franceschi³

et al. 2002

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

We compared the performance of patients with Alzheimer’s disease to that of patients with subcortical vascular dementia (s-IVD) in a set of tasks assessing categorization abilities, sustained and selective attention, and set-shifting and set-maintaining skills. Only the measures of naming and categorization abilities on the Test of Classification and Recall of Pictures (TCRP) proved useful in differentiating AD from s-IVD patients. s-IVD patients showed worse performance than AD on the TCRP categorization measures, while both AD and s-IVD patients were equally impaired in other tasks assessing executive functions (EF). With respect to the naming task, s-IVD patients made significantly more perseverative and unrelated errors than AD patients. Moreover, in the s-IVD group, we found a strong correlation between categorization ability and an attentional test score (Attentional Matrices), while no such correlation emerged in the AD group. These results suggest a dissociated impairment of EF in the 2 dementia groups. In our view, the lack of inhibition and the inability to manipulate complex information are responsible for a greater executive dysfunction in s-IVD patients in comparison with AD patients. The capacity to build up strategies appears more preserved in AD patients, whose impaired performance in executive tasks seems to be related to an impairment of attentional shifting and working memory.

show abstract

Perseverative behavior in Alzheimer's disease and subcortical ischemic vascular dementia.

Cited by 90 publications

References 23 publications

Neuropsychological Deficit in Early Subcortical Vascular Dementia: Comparison to Alzheimer’s Disease

Neuropsychological Deficit in Early Subcortical Vascular Dementia: Comparison to Alzheimer’s Disease

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Frontal Impairment in Subcortical Ischemic Vascular Dementia in Comparison to Alzheimer’s Disease

Contact Info

Product

Resources

About