Perseverations during paired-associate learning in Huntington's disease

Rich, Jill B.; Campodonico, Jeffrey R.; Rothlind, Johannes C.; Bylsma, Frederick W.; Brandt, Jason

doi:10.1080/01688639708403850

Cited by 14 publications

(10 citation statements)

References 25 publications

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“…One case report was excluded since the patient had no clinical signs or symptoms suggesting HD, DNA analysis was not available and he had a negative family history for HD [13]. One article did not use standardized or validated research instruments for OCBs or PBs, and was therefore excluded [14].…”

Section: Resultsmentioning

confidence: 99%

Obsessive-Compulsive and Perseverative Behaviors in Huntington’s Disease

Oosterloo

Craufurd

Nijsten

et al. 2019

JHD

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Background: Neuropsychiatric symptoms are highly prevalent in Huntington’s disease (HD). However, little is known of the prevalence and course of obsessive-compulsive behaviors (OCBs) and perseverative behaviors (PBs) during the progression of the disease. Objective: This review provides a summary of the literature on OCBs and PBs in HD gene expansion carriers (HDGECs). Methods: Pubmed database was searched for articles on OCBs and PBs in HD up to 2017. We used search terms, all synonyms for HD, and various terms for OCBs and PBs. Results: We found 5 case series and 11 original articles that describe a prevalence range of 5 to 52% for OCBs and up to 75% for PBs depending on disease stage and measurement scale used. Premanifest HDGECs report more OCBs compared to controls, and manifest HDGECs report a higher rate of OCBs compared to premanifest HDGECs. OCBs and PBs are associated with a longer disease duration and disease severity in manifest HDGECs, but decrease in the most advanced stages. When HDGECs come closer to estimated motor onset, the companion ratings on OCBs appear to be higher than the self-ratings of HDGECs. Conclusions: Both OCBs and PBs are characteristic neuropsychiatric features of HD. Perseveration is probably best distinguished from OCBs as it occurs without the individual’s full awareness or insight into their presence (and the behavior may not be distressing). Although these behaviors are seldom distinguished, we conclude that differentiating OCBs from PBs in HD is beneficial for the management and treatment of these symptoms in HDGECs.

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Section: Resultsmentioning

confidence: 99%

Obsessive-Compulsive and Perseverative Behaviors in Huntington’s Disease

Oosterloo

Craufurd

Nijsten

et al. 2019

JHD

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“…Identification of location of different patterned objects that have been previously revealed and then occluded. Tests visual memory and learning (Rich et al, 1997).…”

Section: Paired Associates Learningmentioning

confidence: 99%

A mobile, high-throughput semi-automated system for testing cognition in large non-primate animal models of Huntington disease

McBride

Perentos

Morton

2016

Journal of Neuroscience Methods

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We have designed and validated an automated operant behavioural testing system suitable for high throughput cognitive testing in sheep and other medium-sized quadrupeds, such as pigs and dogs. Sheep performance in the two-choice visual discrimination task was very similar to that reported for non-human primates and strongly supports the use of farm animals as pre-clinical models for the study of neurodegenerative diseases.

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“…18 We identified that animals exposed to stroke exhibited robust deficits in two key metrics, namely the % of correct trials performed, which is considered to reference both learning and memory, as well as the number of repeated trials, which is considered to index perseveration. 18,32,33 Both the LOPC paradigms limited these deficits to a level that was comparable to that observed in sham animals. These findings align well with other studies that illustrate the effectiveness of LOPC to improve cognitive deficits after stroke.…”

Section: Discussionmentioning

confidence: 65%

Low oxygen post conditioning improves stroke-induced cognitive impairment

Zhao

Ong

Pietrogrande

et al. 2018

Preprint

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Post-stroke cognitive impairment has proven to be notoriously difficult to treat. In the current study, we sought to both better understand cellular changes that underpin cognitive deficits and to consider the potential restorative benefits of low oxygen post conditioning (LOPC).We were motivated to use LOPC as an intervention as it is one of the few experimental interventions previously shown to improve cognitive function post-stroke. Experimental stroke was induced by photothrombotic occlusion in adult male C57BL/6 mice. Mice were randomly assigned to either a normal atmospheric air exposure or low oxygen (11% O 2 ) exposure groups three days post-occlusion. On day 17 post-stroke, mice were euthanized for histology or biochemical analyses. Stroked mice exposed to LOPC was associated with marked reductions in amyloid-beta both in its absolute level and in the extent of its oligomerization. Exposure to LOPC post-stroke also improved cellular deficits induced by stroke including an increase in vessel density, a reduction in vascular leakage, and restoration of AQP4 polarisation. Critically, stroked mice exposed to LOPC exhibited robust improvements in cognitive function post-stroke, assessed using a touchscreen based pairedassociate learning task. These findings provide compelling pre-clinical evidence of the potential clinical utility of LOPC for enhancing recovery post-stroke.

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Perseverations during paired-associate learning in Huntington's disease

Cited by 14 publications

References 25 publications

Obsessive-Compulsive and Perseverative Behaviors in Huntington’s Disease

Obsessive-Compulsive and Perseverative Behaviors in Huntington’s Disease

A mobile, high-throughput semi-automated system for testing cognition in large non-primate animal models of Huntington disease

Low oxygen post conditioning improves stroke-induced cognitive impairment

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