Peroxisomes in Dermatology. Part I

“…The inclusion of proteins with a striking homology to these receptors, but with no known ligands, termed orphan receptors, has expanded the family to now include approximately 150 different proteins (2). Orphan receptors that are members of this superfamily include peroxisomal proliferator activator receptors (PPARs) (3), testicular receptor (TR4) (4), and steroidogenic factor 1 (SF‐1) (5).…”

Section: Mechanism Of Estrogen Actionmentioning

confidence: 99%

The biological actions of estrogens on skin

Thornton

2002

Experimental Dermatology

221

157

View full text Add to dashboard Cite

There is still extensive disparity in our understanding of how estrogens exert their actions, particularly in non-reproductive tissues such as the skin. Although it has been recognized for some time that estrogens have significant effects on many aspects of skin physiology and pathophysiology, studies on estrogen action in skin have been limited. However, estrogens clearly have an important function in many components of human skin including the epidermis, dermis, vasculature, hair follicle and the sebaceous, eccrine and apocrine glands, having significant roles in skin aging, pigmentation, hair growth, sebum production and skin cancer. The recent discovery of a second intracellular estrogen receptor (ERb) with different cell-specific roles to the classic estrogen receptor (ERa), and the identification of cell surface estrogen

show abstract

“…25 PPARβ/δ is instrumental in damaged skin repair after injury and has been shown to interact closely with the regulatory elements of collagen genes and to promote wound healing by upregulating the synthesis of ECM proteins, such as type I and III collagen, TGF-β1, and fibronectin. 26 These findings imply that PPARβ/δ may be a potential target for skin antiaging intervention.…”

Section: Activation Of Pparβ/δ By Compound 1 In Fibroblastsmentioning

confidence: 98%

Upregulation of Collagen Expression via PPARβ/δ Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza

et al. 2015

View full text Add to dashboard Cite

This study investigated the agonistic activity of magnesium lithospermate B (1), isolated from Salvia miltiorrhiza, on peroxisome proliferator-activated receptor (PPARβ/δ) and the expressions of collagen genes (COL1A1 and COL3A1) and transforming growth factor-β1 (TGF-β1) in models of skin aging. The action of compound 1 as a PPARβ/δ agonist was determined by reporter gene assay, immunostaining, and Western blotting. To determine the antiaging effects of compound 1 on skin, aged Sprague-Dawley rat skin and ultraviolet B (UVB)-irradiated human skin fibroblasts were used. The results show that 1 presented a marked enhancement of both nuclear protein levels and activity of PPARβ/δ in fibroblasts. In addition, 1 prevented downregulation of PPARβ/δ activity in aged rat skin and UVB-induced fibroblasts. Furthermore, 1 increased the expressions of COL1A1, COL3A1, and TGF-β1 in vivo and in a cell culture system. Therefore, the present study shows that compound 1 prevents collagen degradation in aged rat skin and UVB-exposed fibroblasts through PPARβ/δ activation. The therapeutic and cosmetic applications of compound 1 need further investigation.

show abstract

Peroxisomes in Dermatology. Part I

Cited by 11 publications

References 55 publications

A Retrospective Case Series Review of the Peroxisome Proliferator-Activated Receptor Ligand Rosiglitazone in the Treatment of Atopic Dermatitis

A Retrospective Case Series Review of the Peroxisome Proliferator-Activated Receptor Ligand Rosiglitazone in the Treatment of Atopic Dermatitis

The biological actions of estrogens on skin

Upregulation of Collagen Expression via PPARβ/δ Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza

Contact Info

Product

Resources

About