Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator

Pavlíková, Nela; Kortner, Trond M.; Arukwe, Augustine

doi:10.1016/j.aquatox.2010.04.014

Cited by 38 publications

(12 citation statements)

References 80 publications

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“…TBT and TPT are known ligands of the RXR-PPAR␥ heterodimer and induce lipogenic PPAR gene expression in liver and adipose tissue (Inadera and Shimomura, 2005). Pavlikova et al (2010) reported up to 2-fold increase of PPAR expression and that of PPAR˛/ˇiso-types in the liver of salmon exposed to rather high concentrations of TBT through the diet (10 mg/Kg). However, PPAR expression in RTL-W1 cells is rather low, and exposure to organotin compounds did not alter the expression of PPAR˛/ˇ, and led to minor alterations in cell lipids in comparison to the other endocrine disrupters tested.…”

Section: Discussionmentioning

confidence: 97%

Alteration of cellular lipids and lipid metabolism markers in RTL-W1 cells exposed to model endocrine disrupters

et al. 2015

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Section: Discussionmentioning

confidence: 97%

Alteration of cellular lipids and lipid metabolism markers in RTL-W1 cells exposed to model endocrine disrupters

et al. 2015

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“…Interestingly, 1.5 mg/L DCHP increased the expression of both pparγ and cyp19 , suggesting that DCHP affects the amphibian reproductive system differently from rodents. Similarly, increases in pparγ transcription were concurrent with increased cyp19a mRNA levels in tributyltin‐treated salmon . Such disruption of cyp19 could result in increased aromatization, and therefore to an increase in estradiol production.…”

Section: Discussionmentioning

confidence: 85%

Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae

Mathieu-Denoncourt

Martyniuk

Loughery

et al. 2016

Enviro Toxic and Chemistry

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Phthalates are compounds used in polymers to increase their flexibility and are now ubiquitous in the environment as a result of widespread use. Because few studies have focused on the adverse effects of these chemicals in aquatic species, the present study aimed to determine the effects of phthalate diesters in amphibians. Western clawed frog (Silurana tropicalis) tadpoles were acutely exposed to water spiked with monomethyl phthalate (MMP; 1.3-1595.5 mg/L), dimethyl phthalate (DMP; 0.03-924.0 mg/L), or dicyclohexyl phthalate (DCHP; 0.3-99.3 mg/L). Because few studies have addressed the toxicity of these specific phthalates in most organisms, the present study used higher concentrations of these chemicals to determine their toxicity pathways in amphibians and at the same time investigate a suite of genes known to be altered by the well-studied phthalates. Both DMP and DCHP increased larval mortality (9.1-924.0 mg/L DMP and 4.1-99.3 mg/L DCHP), increased frequency of malformations in tadpoles (0.1-34.1 mg/L DMP and 4.1-19.0 mg/L DCHP), and up-regulated cellular stress-related messenger-RNA (mRNA) levels (4.1 mg/L DCHP). To characterize the molecular toxicity pathway of these phthalates in tadpoles, transcriptome analysis was conducted using a custom microarray. Parametric analysis of gene set enrichment revealed important changes in the expression of genes related to drug metabolism and transport, liver metabolism, xenobiotic clearance, and xenobiotic metabolism after DMP and DCHP treatments, although these responses were less pronounced with MMP (the metabolite of DMP). The present study is one of the few studies that demonstrated complementarity between gene expression analysis and organismal effects. Environ Toxicol Chem 2016;35:2511-2522. © 2016 SETAC.

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“…In juvenile salmon TBT decreased estrogen receptor-alpha (ERa) and increased estrogen receptor-beta (ERb) and androgen receptor-beta (ARb). TBT modified the expression patterns of ERa, ERb and ARb in salmon hepatocyte (Pavlikova et al, 2010a). Exposure to organotins or organotin compounds-contaminated seafood may lead to reproductive disruption in female reproductive system of mammals.…”

Section: Triorganotin Compounds and Their Molecular Interactions Withmentioning

confidence: 98%

Triorganotin compounds - ligands for “rexinoid” inducible transcription factors: Biological effects

Brtko

Dvořák

2015

Toxicology Letters

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Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator

Cited by 38 publications

References 80 publications

Alteration of cellular lipids and lipid metabolism markers in RTL-W1 cells exposed to model endocrine disrupters

Alteration of cellular lipids and lipid metabolism markers in RTL-W1 cells exposed to model endocrine disrupters

Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae

Triorganotin compounds - ligands for “rexinoid” inducible transcription factors: Biological effects

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