Peroxisome proliferator-activated receptors and biotransformation responses in relation to condition factor and contaminant burden in tilapia species from Ogun River, Nigeria

Adeogun, Aina O.; Ibor, Oju R.; Regoli, Francesco; Arukwe, Augustine

doi:10.1016/j.cbpc.2015.12.006

Cited by 18 publications

(11 citation statements)

References 70 publications

(83 reference statements)

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“…Although PAHs are identified as ligands for PPAR-α in human cells (Kim et al, 2005), this interaction is not known for fish. However, several studies have shown that petroleum compounds affect transcription levels of genes related to lipid metabolism (Bilbao et al, 2010;Adeogun et al, 2016;Xu et al, 2016;Cocci et al, 2017). Furthermore, PAH exposure altered lipid plasma parameters in Chinook salmon (Oncorhynchus tshawytscha) in a similar pattern of that found in starving fish (Meador et al, 2006).…”

Section: Introductionmentioning

confidence: 73%

“…The crude oil treatment did not affect transcription levels of ppar-α and -γ in exposed polar cod, which is in contrast to recent experimental studies on freshwater and marine fish. Waterborne exposure to relatively high levels of PAHs caused a significant activation of PPAR isotypes at transcription level next to induced CYP1A activity in exposed fish (Adeogun et al, 2016;Cocci et al, 2017). Furthermore, the study by Bilbao et al (2010) showed that fuel oil exposure induced the transcriptional up-regulation of ppar-α, rxr and aox1 in thicklip grey mullets (Chelon labrosus), as well as typical effects associated to peroxisome proliferation in marine organisms.…”

Section: Effects Of Crude Oil On Genes and Plasma Parameters Related mentioning

confidence: 99%

“…However, as discussed before polar cod were exposed to relatively low crude oil doses that may not have been high enough to induce significant effects in endpoints related to lipid metabolism. Furthermore, it is important to highlight that polar cod were exposed through the food, which is in contrast to the waterborne exposure in the studies on thicklip grey mullets (Bilbao et al, 2010), seabream (Cocci et al, 2017) and tilapia species (Adeogun et al, 2016). If thermodynamic equilibrium occurs between diet and water, whole-body uptake of PAHs may be similar from these two exposure routes (Meador et al, 1995), however, additional factors such as differential tissue metabolism and enterohepatic circulation may result in disparate internal PAH concentration in fish.…”

Section: Effects Of Crude Oil On Genes and Plasma Parameters Related mentioning

confidence: 99%

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Effects of dietary crude oil exposure on molecular and physiological parameters related to lipid homeostasis in polar cod ( Boreogadus saida )

Vieweg

Bilbao

Meador

et al. 2018

Comparative Biochemistry and Physiology Part C: Toxicology &

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Polar cod is an abundant Arctic key species, inhabiting an ecosystem that is subjected to rapid climate change and increased petroleum related activities. Few studies have investigated biological effects of crude oil on lipid metabolism in this species, despite lipids being a crucial compound for Arctic species to adapt to the high seasonality in food abundance in their habitat. This study examines the effects of dietary crude oil exposure on transcription levels of genes related to lipid metabolism (peroxisome proliferator-activated receptors [ppar-α, ppar-γ], retinoic X receptor [rxr-β], palmitoyl-CoA oxidase [aox1], cytochrome P4507A1 [cyp7α1]), reproduction (vitellogenin [vtg-β], gonad aromatase [cyp19a1]) and biotransformation (cytochrome P4501A1 [cyp1a1], aryl hydrocarbon receptor [ahr2]). Exposure effects were also examined through plasma chemistry parameters. Additional fish were exposed to a PPAR-α agonist (WY-14,643) to investigate the role of PPAR-α in their lipid metabolism. The dose-dependent up-regulation of cyp1a1 reflected the activation of genes related to PAH biotransformation upon crude oil exposure. The crude oil exposure did not significantly alter the mRNA expression of genes involved in lipid homeostasis except for cyp7α1 transcription levels. Plasma levels of cholesterol and alanine transaminase showed significant alterations in fish exposed to crude oil at the end of the experiment. WY exposure induced a down-regulation of ppar-α, an effect contrary to studies performed on other fish species. In conclusion, this study showed clear effects of dietary crude oil exposure at environmentally relevant concentrations on xenobiotic biotransformation but revealed only weak alterations in the lipid metabolism of polar cod.

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Section: Introductionmentioning

confidence: 73%

Section: Effects Of Crude Oil On Genes and Plasma Parameters Related mentioning

confidence: 99%

Section: Effects Of Crude Oil On Genes and Plasma Parameters Related mentioning

confidence: 99%

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Effects of dietary crude oil exposure on molecular and physiological parameters related to lipid homeostasis in polar cod ( Boreogadus saida )

Vieweg

Bilbao

Meador

et al. 2018

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…The PPARγ activator, TBT activated an obesogen response by increasing body weight and whole-lipid content in Chinook salmon ( Oncorhynchus tshawytscha ) and condition factor, triglycerides, and hepatosomatic index in zebrafish (71). Interestingly, toxicants that activate PPARs may enhance condition factor while also increasing other stress responses typically associated with poor physiological conditions (72). …”

Section: Resultsmentioning

confidence: 99%

Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus

Baldwin

Boswell

Ginjupalli

et al. 2017

Nuclear Receptor Research

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The nuclear receptors (NRs) are ligand-dependent transcription factors that respond to various internal as well as external cues such as nutrients, pheromones, and steroid hormones that play crucial roles in regulation and maintenance of homeostasis and orchestrating the physiological and stress responses of an organism. We annotated the Fundulus heteroclitus (mummichog; Atlantic killifish) nuclear receptors. Mummichog are a non-migratory, estuarine fish with a limited home range often used in environmental research as a field model for studying ecological and evolutionary responses to variable environmental conditions such as salinity, oxygen, temperature, pH, and toxic compounds because of their hardiness. F. heteroclitus have at least 74 NRs spanning all seven gene subfamilies. F. heteroclitus is unique in that no RXRα member was found within the genome. Interestingly, some of the NRs are highly conserved between species, while others show a higher degree of divergence such as PXR, SF1, and ARα. Fundulus like other fish species show expansion of the RAR (NR1B), Rev-erb (NR1D), ROR (NR1F), COUPTF (NR2F), ERR (NR3B), RXR (NR2B), and to a lesser extent the NGF (NR4A), and NR3C steroid receptors (GR/AR). Of particular interest is the co-expansion of opposing NRs, Reverb-ROR, and RAR/RXR-COUPTF.

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“…17: 477-485 (2017) Misaki, Gelman, & Watabe, 2007), tilapia (Adeogun, Ibor, Regoli, & Aru kwe, 2016), sea bass (Boukouvala et al, 2004), orange-spotted grouper , g rass carp (He et al, 2012). Although there were some reports on PPARγ related to the fish nutrition, immune and environ ment (Liang, Zhao, Li, & Gao, 2015;Luo et al, 2015;Adeogun et al, 2016), the regulation and function of fish PPARγ remain unknown. Especially, limited information is available about the expression of PPARγ in response to dietary different lipid levels.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Wang¹,

Yang²,

Liu³

et al. 2017

Turk. J. Fish. Aquat. Sci.

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Redlip mullet (Liza haematocheila) PPARγ cDNA (lhPPARγ) by reverse transcription polymerase chain reaction (RT -PCR) and rapid amplification of cDNA ends (RACE) were isolated in this study. The full-length cDNA was 2985 bp, consisted of a 200 bp 5'UTR, 1183 bp 3'UTR and 1599 bp ORF encoding a polypeptide with 533 amino acids. lhPPARγ protein was predicted to consist of four domains, i.e. N-terminal domain, DNA-binding domain, C-terminal ligand binding domain and flexible hinge domain. Real time quantitative RT-PCR revealed that lhPPARγ mRNA was detected in all tested tissues. The highest expression level of lhPPARγ mRNA was observed in abdomen fat followed by intestine, gill, kidney, liver, skin, brain, spleen, stomach, liver, heart and muscle. These results suggested that lhPPARγ was functionally and evolutionarily conserved between redlip mullet and other vertebrates. Six iso-nitrogenous diets with different lipid level (from 2.0% to 14.6%) were fed to triplicate groups. Although fish fed diets containing 14.6% lipid showed higher lhPPARγ mRNA expression in the liver, intestine and muscle than fish fed other diets, no significant difference was observed, which indicated redlip mullet might adapt to high lipid level below 14.6%.

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Peroxisome proliferator-activated receptors and biotransformation responses in relation to condition factor and contaminant burden in tilapia species from Ogun River, Nigeria

Cited by 18 publications

References 70 publications

Effects of dietary crude oil exposure on molecular and physiological parameters related to lipid homeostasis in polar cod ( Boreogadus saida )

Effects of dietary crude oil exposure on molecular and physiological parameters related to lipid homeostasis in polar cod ( Boreogadus saida )

Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus

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