2013
DOI: 10.1074/jbc.m111.317487
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Peroxisome Proliferator-activated Receptor γ Agonists Induce Cell Cycle Arrest through Transcriptional Regulation of Krüppel-like Factor 4 (KLF4)

Abstract: Background: PPAR␥ serves as a master transcriptional regulator of glucose and lipid metabolism, but it also plays an important role in carcinogenesis. Results: Up-regulation of KLF4 upon PPAR␥ activation is mediated through the PPRE in the KLF4 promoter. Conclusion: KLF4 partly mediates PPAR␥-induced cell proliferation inhibition. Significance: This study provides further insights into the PPAR␥ signal transduction pathway as well as a novel cancer therapeutic strategy.

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Cited by 37 publications
(41 citation statements)
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References 30 publications
(31 reference statements)
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“…MTS Cell Proliferation Assay-MTS cell proliferation assay was performed as described previously (25). Briefly, cells were seeded in 96-well plates at a density of 1 ϫ 10 3 cells/well and then incubated in the absence or presence of 4 mM SB at 48 h intervals.…”
Section: Methodsmentioning
confidence: 99%
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“…MTS Cell Proliferation Assay-MTS cell proliferation assay was performed as described previously (25). Briefly, cells were seeded in 96-well plates at a density of 1 ϫ 10 3 cells/well and then incubated in the absence or presence of 4 mM SB at 48 h intervals.…”
Section: Methodsmentioning
confidence: 99%
“…Cells were cultured in RPMI 1640 medium with 10% fetal bovine serum and antibiotics. Transfections were performed as described previously (25). Cells were transfected with siRNAs (25 nM) by HiPerFect (Qiagen) following the manufacturers' protocol.…”
Section: Methodsmentioning
confidence: 99%
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“…ID1 siRNA (GS3397; Qiagen), c-Jun siRNA (GS3725; Qiagen), c-Fos siRNA (GS8061; Qiagen), and negative control siRNA (1027310; Qiagen) were purchased from Qiagen. RNA purification and qRT-PCR were performed as described previously (31). The primers used are listed in Table 1.…”
Section: Methodsmentioning
confidence: 99%