Peroxisome proliferator-activated receptor γ activation inhibits liver growth through miR-122-mediated downregulation of cMyc

Yarushkin, Andrei A.; Kazantseva, Yuliya A.; Kobelev, Vyacheslav S.; Pustylnyak, Yuliya A.; Pustylnyak, Vladimir O.

doi:10.1016/j.ejphar.2017.01.016

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…MiR-122 is involved in HBV replication [14,29] and the regulation of cell proliferation [14,30] in HBV infection. In HCV infection, miR-122 is associated with hepatocyte proliferation [31], apoptosis [32], lipid metabolism [33], interferon response [6], liver fibrosis [6], and HCV replication [12,13]. Further studies will be needed at this point.…”

Section: Discussionmentioning

confidence: 99%

Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis

Nakamura¹,

Jiang²,

Haga³

et al. 2017

PLoS ONE

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BackgroundNoninvasive methods to accurately and conveniently evaluate liver fibrosis are desirable. MicroRNA (miR) is one of the candidates. MiRs are small RNAs consisting of 19–25 nucleotides that negatively regulate many target genes at transcriptional levels. Recently, many researchers have focused on circulating miRs in the blood stream as biomarkers. Hepatic miR-122 has been reported to have an association with viral replication and hepatic fibrosis in chronic hepatitis B virus (HBV) and hepatic C virus (HCV) infection.MethodsWe measured serum miR-122 levels in HBV- and HCV-infected patients confirmed with liver biopsy. We also investigated a novel liver fibrosis marker Wisteria floribunda agglutinin-positive Mac-2 binding protein [WFA(+)-M2BP]. We evaluated the diagnostic usefulness of these markers in hepatic fibrosis and inflammation of patients with chronic viral infection.ResultsThe serum miR-122 levels of HBV-infected patients were higher than those of the control subjects. In HBV-infected patients, the serum miR-122 levels of patients with advanced liver fibrosis were significantly lower. Serum WFA(+)-M2BP was significantly higher dependent on both the staging of fibrosis and the grading of inflammatory activity in patients with both HBV and HCV infection. We also observed that higher serum WFA(+)-M2BP levels augmented the prediction of advanced liver fibrosis among HBV-infected patients with lower serum miR-122 levels.ConclusionsA lower serum miR-122 level is a useful predictor of advanced liver fibrosis in HBV-infected patients. Serum WFA(+)-M2BP could predict liver fibrosis in both HBV and HCV infection. The combination of these markers may result in the more accurate evaluation of liver fibrosis in HBV infection.

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Section: Discussionmentioning

confidence: 99%

Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis

Nakamura¹,

Jiang²,

Haga³

et al. 2017

PLoS ONE

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“…Besides, miRNAs also regulate Sp1 and other transcription factors and thereby serve as tumor suppressor-like molecules (Fulciniti et al, 2016;Hedrick et al, 2016;Li et al, 2018;Lv and Wang, 2018). Several studies demonstrated the cross talk between pro-oncogenic microRNAs and oncogene cellular myelocytomatosis (c-Myc) (Zheng et al, 2014;Chen et al, 2017;Yarushkin et al, 2017). The regulation of microRNAs by transcription factors will confer alternative strategies to target microRNAs as potential therapeutic interventions.…”

Section: B Regulation Of Microrna Expressionmentioning

confidence: 99%

Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury

Lee¹,

Yuan²,

Kerr³

et al. 2020

Pharmacol Rev

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Significance Statement--MicroRNAs have been studied extensively during the last two decades in cancer and organ injury, including acute lung injury, myocardial infarction, and acute gut injury, for their regulation of gene expression, application as diagnostic markers, and therapeutic potentials. In this review, we specifically emphasize the pros and cons of different delivery approaches to modulate microRNAs, as well as the most recent exciting progress in the field of therapeutic targeting of microRNAs for disease treatment in patients.

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“…MicroRNAs (miRNAs) serve as post-transcriptional markers of gene expression [3,4] and form base pairs with target messenger RNAs [5,6] at the 3′,5′-untranslated regions or within the coding sequence [7,8], whose differential expression signature is a hallmark of human cancers and has been identified in various human tumors [9,10], such as the prostate [11][12][13], ovary [14,15], lung [16][17][18], breast [19,20], brain [21,22], stomach [23][24][25], liver [26,27], and pituitary [6,28,29]. Depending on corresponding cellular contexts and target genes [30,31], miRNAs are related with pituitary tumorigenesis [32], dysfunction, neurodegeneration [33], and metastatic non-functioning pituitary carcinoma [34].…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs and Target Genes in Pituitary Adenomas

et al. 2018

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Pituitary adenomas account for the top three primary intracranial tumors in terms of total incidence rates. The clinical symptoms presented by the disease are often characterized by a series of systemic endocrine disorders, severe occupational lesions, and even some malignant features, and therefore early diagnosis and predicting recurrence would be instructive for clinical treatment of pituitary adenomas. An increasing number of specific microRNA (miRNA) expression signatures have been identified in pituitary, and miRNAs are related with the pituitary tumorigenesis, dysfunction, neurodegeneration, and metastatic non-functioning pituitary carcinoma. Here, this paper reviews the effects of aberrant miRNA expression in human pituitary adenomas and summarizes some corresponding target genes and biological significance over the last 7 years (2010-2017).

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Peroxisome proliferator-activated receptor γ activation inhibits liver growth through miR-122-mediated downregulation of cMyc

Cited by 6 publications

References 30 publications

Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis

Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis

Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury

MicroRNAs and Target Genes in Pituitary Adenomas

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