Peroxisome proliferator-activated receptor α agonist attenuates oxidized-low density lipoprotein induced immune maturation of human monocyte-derived dendritic cells

Shi, Hongyu; Ge, Junbo; Fang, Wei-Yi; Yao, Kang; Sun, Aijun; Huang, Rongchong; Jia, Qingzhe; WANG, Ke-qiang; Zou, Yunzeng; Cao, Xuetao

doi:10.1097/00029330-200809010-00030

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…Studies demonstrated that the peroxisome proliferator activated receptor gamma (PPAR-γ agonist ciglitazone inhibited the ox-LDL-induced maturation and immune functions of DCs (Luo et al, 2004 ). Interestingly, it was shown that the PPAR-α agonist fenofibrate, inhibited the ox-LDL-induced immune maturation of DCs (Shi et al, 2008 ). These effects of PPARs may partially explain their ability to slow atherosclerosis progression and reduce the risk of coronary heart disease independently from their metabolic effects.…”

Section: Dendritic Cells and Atherosclerosismentioning

confidence: 99%

Macrophages, dendritic cells, and regression of atherosclerosis

Feig¹,

Feig²

2012

Front. Physio.

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Atherosclerosis is the number one cause of death in the Western world. It results from the interaction between modified lipoproteins and cells such as macrophages, dendritic cells (DCs), T cells, and other cellular elements present in the arterial wall. This inflammatory process can ultimately lead to the development of complex lesions, or plaques, that protrude into the arterial lumen. Ultimately, plaque rupture and thrombosis can occur leading to the clinical complications of myocardial infarction or stroke. Although each of the cell types plays roles in the pathogenesis of atherosclerosis, the focus of this review will be primarily on the macrophages and DCs. The role of these two cell types in atherosclerosis is discussed, with a particular emphasis on their involvement in atherosclerosis regression.

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Section: Dendritic Cells and Atherosclerosismentioning

confidence: 99%

Macrophages, dendritic cells, and regression of atherosclerosis

Feig¹,

Feig²

2012

Front. Physio.

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“…As a result, there were 12 highly common pathways PPAR α -dependent in both tissues, including 4 upregulated and 8 downregulated pathways in PPAR α KO mice (see Table 3 ). The most downregulated pathways were metabolism related pathway, such as fatty acid metabolism, tryptophan metabolism, pyruvate metabolism, pantothenate and CoA biosynthesis, biosynthesis of unsaturated fatty acids, beta-Alanine metabolism, and glycerolipid metabolism identified in both liver and intestine [ 28 – 31 ]. Besides, PPAR signaling pathway was also identified as one of the most common downregulated pathways, which is part of endocrine system.…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARαKnockout by Gene Set Enrichment Analysis

Wang

Yang

et al. 2011

PPAR Research

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Gene expression profiling of PPARα has been used in several studies, but fewer studies went further to identify the tissue-specific pathways or genes involved in PPARα activation in genome-wide. Here, we employed and applied gene set enrichment analysis to two microarray datasets both PPARα related respectively in mouse liver and intestine. We suggested that the regulatory mechanism of PPARα activation by WY14643 in mouse small intestine is more complicated than in liver due to more involved pathways. Several pathways were cancer-related such as pancreatic cancer and small cell lung cancer, which indicated that PPARα may have an important role in prevention of cancer development. 12 PPARα dependent pathways and 4 PPARα independent pathways were identified highly common in both liver and intestine of mice. Most of them were metabolism related, such as fatty acid metabolism, tryptophan metabolism, pyruvate metabolism with regard to PPARα regulation but gluconeogenesis and propanoate metabolism independent of PPARα regulation. Keratan sulfate biosynthesis, the pathway of regulation of actin cytoskeleton, the pathways associated with prostate cancer and small cell lung cancer were not identified as hepatic PPARα independent but as WY14643 dependent ones in intestinal study. We also provided some novel hepatic tissue-specific marker genes.

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“…CD14 ? monocytes were isolated from PBMCs after plastic adherence and negatively selected to approximately 95% purity by using cocktail immunomagnetic beads (Miltenyi Biotec, Bergisch Gladbach, Germany) [5,10,11,13].…”

Section: Isolation Of Monocytesmentioning

confidence: 99%

Effects of Gekko Sulfated Polysaccharide–Protein Complex on the Defective Biorheological Characters of Dendritic Cells Under Tumor Microenvironment

Chen

Zhang

et al. 2011

Cell Biochem Biophys

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We previously isolated a sulfated polysaccharide-protein complex from Gekko swinhonis Guenther, a traditional Chinese medicine, and have demonstrated its direct anti-cancer effect on human hepatocellular carcinoma cell line SMMC-7721. Here we investigated the effects of Gekko sulfated polysaccharide-protein complex (GSPP) on the defective biorheological characters of dendritic cells (DCs) under SMMC-7721 microenvironment. Our findings have shown that the biorheological properties of DCs were severely impaired by SMMC-7721 microenvironment, including decreased cell deformability, migration, and electrophoresis mobility, increased osmotic fragilities, and changed organizations of cytoskeletal proteins. We also found decreased secretion of interleukin (IL)-12 and increased secretion of IL-10 in DCs. However, supernatant collected from nonmalignant liver cells had no effect on these parameters. SMMC-7721 cells were treated with GSPP and the supernatant was used to culture DCs. We found that the defective biorheological parameters of DCs, except for osmotic fragility, were partially or completely improved. The secretion of IL-12 did not change as compared with that of DCs in SMMC-7721 microenvironment, but the secretion of IL-10 was resumed to the control level. Our results indicate that GSPP could partially restore the defective biorheological characteristics of DCs via modifying the tumor microenvironment and decreasing the secretion of IL-10 of DCs.

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Peroxisome proliferator-activated receptor α agonist attenuates oxidized-low density lipoprotein induced immune maturation of human monocyte-derived dendritic cells

Cited by 7 publications

References 12 publications

Macrophages, dendritic cells, and regression of atherosclerosis

Macrophages, dendritic cells, and regression of atherosclerosis

A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARαKnockout by Gene Set Enrichment Analysis

Effects of Gekko Sulfated Polysaccharide–Protein Complex on the Defective Biorheological Characters of Dendritic Cells Under Tumor Microenvironment

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