Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Pro12Ala Gene Polymorphism and Oxidative Stress in Menopausal Women with Cardiovascular Disease from North Indian Population of Punjab

Amrita, Jyot; Mahajan, Mridula; Bhanwer, A.J.S.; Mohan, Gurinder; Matharoo, Kawaljit

doi:10.1080/09723757.2017.1317106

Cited by 3 publications

(4 citation statements)

References 51 publications

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“…In the present studied population with CVD, the frequency of T allele carrier was more as compare to subjects without CVD. Similar, to the present study Associations of various candidate genes with predisposition to CVD have been extensively reported and polymorphism at multiple genes has been coupled with differential effects of lipid metabolism with this disease (21). Adiponectin attenuates expression of class A scavenger receptor in human macrophages and inhibits transformation of macrophages to foam cells (36).…”

Section: Discussionsupporting

confidence: 82%

“…Gumanova et al (24) in their study found that higher levels of NO are significantly associated with coronary lesions though, some studies reported increased activity of SOD in ischemic heart disease patients (25). On the other hand, other studies similar to our study revealed decreased activity of SOD (19,21,26).…”

Section: Discussionsupporting

confidence: 79%

“…Another study by Bhargava et al (20) reported increased levels of MDA in patients with CAD and CVD with hyperhomocystenemia. Similarly, in our previous report, we had observed increased levels of MDA in menopausal women suffering from CVD (21). On the contrary, Lopes et al (22) observed no difference in the concentration of MDA between atherosclerotic subjects and controls.…”

Section: Discussionsupporting

confidence: 76%

“…For another studied prooxidant LDL carbonyl protein, significant difference in the mean levels was again observed in subjects with CVD as compared to subjects without CVD. Similarly, increased levels of carbonyl protein were also observed in the patients of CVD in our earlier reported study (21) and in a study conducted by Lopes et al (22). In another study by Jawalekar et al (23) increase in protein carbonyl in red cell extract in the patients with IHD, HTN and cerebrovascular disease as compared to the healthy controls were reported.…”

Section: Discussionsupporting

confidence: 75%

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Association of AdipoQ gene variation (rs1501299) and oxidative stress with cardiovascular disease in North West Indian population of Punjabi women

Amrita

Mahajan²,

Bhanwer³

et al. 2021

J Med Biochemistry

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Background: Till to date whether adiponectin AdipoQ gene variation (rs 1501299) is associated with cardiovascular disease, still remains controversial. Therefore, we aimed to relate the SNP (rs1501299) of adiponectin gene and oxidative stress in context to CVD in Punjabi women of North West India. Methods: In the present case-control study menopausal women with CVD as cases (n=265) and menopausal women without CVD as controls (n=258) were recruited. Genotyping of rs1501299 single nucleotide polymorphism of adiponectin gene was carried out by RFLP-PCR analysis. Biochemical parameters were analyzed according to the standard procedures. Results: Distribution of homozygous TT genotype of normolipidemic (p=0.001) and hyperlipidemic (p=0.001) women with CVD were significantly higher as compared to women without CVD. rs1501299 T allele carriers with CVD also showed significant (p=0.001) higher frequency distribution as compared to women without CVD. Under recessive model of inheritance TT mutant type homozygotes conferred ̴ 9 fold higher risk [p=0.001; OR= 9.60 (2.92-31.58)] towards CVD susceptibility for MDA>1.50; ̴ 11 fold higher risk [p=0.007; OR= 11.11 (1.49-82.83)] towards CVD for LDL carbonyl protein>15.04 and ̴ 9 fold higher risk [p=0.001; OR= 9.75 (2.30-41.22)] towards CVD susceptibility for SOD≤5.55. Under logistic regression analysis oxidative stress and TT genotype were significantly correlated with CVD. Conclusion: Our study revealed significant association of AdipoQ (rs1501299) gene polymorphism and oxidative stress with cardiovascular disease in Punjabi women of North West India. However, additional studies are required to support these findings. Keywords: AdipoQ gene, Association, Cardiovascular disease, MDA, RFLP-PCR, SOD

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 75%

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Association of AdipoQ gene variation (rs1501299) and oxidative stress with cardiovascular disease in North West Indian population of Punjabi women

Amrita

Mahajan²,

Bhanwer³

et al. 2021

J Med Biochemistry

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Muscle food and human health: A systematic review from the perspective of external and internal oxidation

Wang

et al. 2023

Trends in Food Science & Technology

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Prevalence of AdipoQ (+276 G/T) gene polymorphism in Punjabi menopausal women with and without family history of cardiovascular disease

Amrita¹,

Mahajan²

2020

IJCBR

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Cardiovascular disease (CVD) is a serious threat in female population particularly after menopause. The prevalence of CVD with associated risk factors in Punjabi population after menopause is rapidly increasing. Adiponectin polymorphism ADIPOQ +276G/T is located in intron 2 which results from G to T substitution. The variants of adiponectin gene are found to be associated with obesity, metabolic syndrome markers and cardiovascular disease. The present study aimed to screen the prevalence of +276 G/T polymorphism of AdipoQ gene in menopausal women of Punjab with and without the family history of CVDGenomic DNA was extracted from intravenous blood for all the participants. Genotyping of +276 G/T polymorphism in the AdipoQ gene was done by polymerase chain reaction (PCR) – based Restriction Fragment Length Polymorphism (RFLP).Prevalence of TT genotype was higher among cases (22.3%) than among controls (4.4%). Statistical significant difference (p<0.05) was observed in the frequency distribution of TT genotype (p=0.020) in cases with positive family h/o CVD. TT genotype also provided significant risk ~9 folds towards CVD predisposition [p=0.001; OR=9.90(3.77-25.99)] in cases with negative family h/o CVD.The present study reveals that prevalence of TT genotype was found to be more in cases as compared to controls and also positive family history of CVD alone does not seem to be a good predictor as individual risk for cardiovascular disease in Punjabi menopausal women.

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Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Pro12Ala Gene Polymorphism and Oxidative Stress in Menopausal Women with Cardiovascular Disease from North Indian Population of Punjab

Cited by 3 publications

References 51 publications

Association of AdipoQ gene variation (rs1501299) and oxidative stress with cardiovascular disease in North West Indian population of Punjabi women

Association of AdipoQ gene variation (rs1501299) and oxidative stress with cardiovascular disease in North West Indian population of Punjabi women

Muscle food and human health: A systematic review from the perspective of external and internal oxidation

Prevalence of AdipoQ (+276 G/T) gene polymorphism in Punjabi menopausal women with and without family history of cardiovascular disease

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