Peroxisome biogenesis, protein targeting mechanisms and PEX gene functions in plants

Cross, Laura L.; Ebeed, Heba Talat; Baker, Alison

doi:10.1016/j.bbamcr.2015.09.027

Cited by 57 publications

(62 citation statements)

References 131 publications

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“…This involves cleaving PTS2 and the collaboration of a battery of proteins called peroxins (PEXs) which are peroxisomal biogenesis factors encoded by PEX genes involved in matrix protein transport through PTS1 and PTS2 pathways. They are located in both the cytosol and peroxisomal membrane [34].…”

Section: Introductionmentioning

confidence: 99%

Plant peroxisomes: A nitro-oxidative cocktail

et al. 2017

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Although peroxisomes are very simple organelles, research on different species has provided us with an understanding of their importance in terms of cell viability. In addition to the significant role played by plant peroxisomes in the metabolism of reactive oxygen species (ROS), data gathered over the last two decades show that these organelles are an endogenous source of nitric oxide (NO) and related molecules called reactive nitrogen species (RNS). Molecules such as NO and H2O2 act as retrograde signals among the different cellular compartments, thus facilitating integral cellular adaptation to physiological and environmental changes. However, under nitro-oxidative conditions, part of this network can be overloaded, possibly leading to cellular damage and even cell death. This review aims to update our knowledge of the ROS/RNS metabolism, whose important role in plant peroxisomes is still underestimated. However, this pioneering approach, in which key elements such as β-oxidation, superoxide dismutase (SOD) and NO have been mainly described in relation to plant peroxisomes, could also be used to explore peroxisomes from other organisms.

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Section: Introductionmentioning

confidence: 99%

Plant peroxisomes: A nitro-oxidative cocktail

et al. 2017

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“…1; reviewed in 1, 5]. Peroxisomal membrane proteins (PMPs) can be recognized by PEX19, a receptor that docks with PEX3 in the membrane to allow PMP insertion (Fig.…”

Section: Introductionmentioning

confidence: 99%

Pexophagy and peroxisomal protein turnover in plants

Young

Bartel

2016

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Peroxisomes are dynamic, vital organelles that sequester a variety of oxidative reactions and their toxic byproducts from the remainder of the cell. The oxidative nature of peroxisomal metabolism predisposes the organelle to self-inflicted damage, highlighting the need for a mechanism to dispose of damaged peroxisomes. In addition, the metabolic requirements of plant peroxisomes change during development, and obsolete peroxisomal proteins are degraded. Although pexophagy, the selective autophagy of peroxisomes, is an obvious mechanism for executing such degradation, pexophagy has only recently been described in plants. Several recent studies in the reference plant Arabidopsis thaliana implicate pexophagy in the turnover of peroxisomal proteins, both for quality control and during functional transitions of peroxisomal content. In this review, we describe our current understanding of the occurrence, roles, and mechanisms of pexophagy in plants.

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“…Since all peroxisomal proteins are encoded in the nucleus, they need to be imported into peroxisomes from the cytosol through a process mediated by peroxins (or PEX proteins), most of which are conserved across kingdoms (Hu et al, 2012;Cross et al, 2016). Recent molecular genetic studies have shed light on the function of plant PEX proteins and revealed regulatory mechanisms.…”

Section: Peroxisome Protein Import and Proliferation/divisionmentioning

confidence: 99%

Peroxisomes: versatile organelles with diverse roles in plants

Pan

Wang

et al. 2019

New Phytologist

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Summary Peroxisomes are small, ubiquitous organelles that are delimited by a single membrane and lack genetic material. However, these simple‐structured organelles are highly versatile in morphology, abundance and protein content in response to various developmental and environmental cues. In plants, peroxisomes are essential for growth and development and perform diverse metabolic functions, many of which are carried out coordinately by peroxisomes and other organelles physically interacting with peroxisomes. Recent studies have added greatly to our knowledge of peroxisomes, addressing areas such as the diverse proteome, regulation of division and protein import, pexophagy, matrix protein degradation, solute transport, signaling, redox homeostasis and various metabolic and physiological functions. This review summarizes our current understanding of plant peroxisomes, focusing on recent discoveries. Current problems and future efforts required to better understand these organelles are also discussed. An improved understanding of peroxisomes will be important not only to the understanding of eukaryotic cell biology and metabolism, but also to agricultural efforts aimed at improving crop performance and defense.

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Peroxisome biogenesis, protein targeting mechanisms and PEX gene functions in plants

Cited by 57 publications

References 131 publications

Plant peroxisomes: A nitro-oxidative cocktail

Plant peroxisomes: A nitro-oxidative cocktail

Pexophagy and peroxisomal protein turnover in plants

Peroxisomes: versatile organelles with diverse roles in plants

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