Peroxisomal Membrane Protein PMP34 Is Involved in the Human Papillomavirus Infection Pathway

Ito, Rie; Kitamura, Koji; Inohara, Hidenori; Yusa, Kosuke; Kaneda, Yasufumi; Nimura, Keisuke

doi:10.3389/fviro.2022.870922

Cited by 2 publications

(1 citation statement)

References 34 publications

(44 reference statements)

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“…The human papillomavirus (HPV) is a DNA virus from the Papillomaviridae family and the main cause of cervical and anogenital cancers. A recent study, using a genome-wide CRISPR screen, has identified PMP34 as an important protein for the HPV life cycle, although the underlying mechanisms have not been resolved (493).…”

Section: Human Papillomavirusmentioning

confidence: 99%

The physiological functions of human peroxisomes

Wanders

Baes

Ribeiro

et al. 2023

Physiological Reviews

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Peroxisomes are subcellular organelles which play a central role in human physiology by catalyzing a range of unique metabolic functions. The importance of peroxisomes for human health is exemplified by the existence of a group of usually severe diseases caused by an impairment in one or more peroxisomal functions. Among others these include the Zellweger spectrum disorders, X-linked adrenoleukodystrophy and Refsum disease. In order to fulfill their role in metabolism, peroxisomes require the continued interaction with other subcellular organelles including lipid droplets, lysosomes, the endoplasmic reticulum, and mitochondria. In recent years it has become clear that the metabolic alliance between peroxisomes and other organelles requires the active participation of tethering proteins to bring the organelles physically closer together thereby achieving efficient transfer of metabolites. This review intends to describe the current state of knowledge about the metabolic role of peroxisomes in humans with particular emphasis on the metabolic partnership between peroxisomes and other organelles and the consequences of genetic defects in these processes. We will also describe the biogenesis of peroxisomes and the consequences of the multiple genetic defects therein. In addition, we will discuss the functional role of peroxisomes in different organs and tissues and will include relevant information derived from model systems notably peroxisomal mouse models. Finally, we will pay particular attention to a hitherto underrated role of peroxisomes in viral infections.

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Section: Human Papillomavirusmentioning

confidence: 99%

The physiological functions of human peroxisomes

Wanders

Baes

Ribeiro

et al. 2023

Physiological Reviews

View full text Add to dashboard Cite

show abstract

Multiomics data analyses to identify SLC25A17 as a novel biomarker to predict the prognosis and immune microenvironment in head and neck squamous cell carcinoma

Shi

Huang

et al. 2023

BMC Bioinformatics

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Objective This study aims to explore the predictive value of SLC25A17 in the prognosis and tumor microenvironment (TME) of patients with head and neck squamous cell carcinoma (HNSCC) and to provide ideas for individual clinical treatment. Methods A pancancer analysis of the differential expression of SLC25A17 among different tumors was first conducted via the TIMER 2.0 database. Subsequently, the expression of SLC25A17 and related clinical information of HNSCC patients were obtained from the TCGA database, and patients were divided into two groups according to the median value of SLC25A17 expression. K‒M survival analysis was conducted to compare the overall survival (OS) and progression-free survival (PFS) between the groups. The Wilcoxon test was used to compare the distribution of SLC25A17 in different clinical characteristics, and univariate Cox and multivariate Cox analyses were performed to analyze independent prognostic factors to establish a predictive nomogram. Calibration curves were generated to verify the reliability of predicting 1-year, 3-year and 5-year survival rates and another cohort (GSE65858) was used for external validation. Gene set enrichment analysis was conducted to compare the enriched pathways, and the immune microenvironment was assessed using the CIBERSORT and estimate packages. Furthermore, the expression levels of SLC25A17 in immune cells were also analyzed with single-cell RNA-seq via the TISCH. Moreover, the immunotherapeutic response and chemotherapy drug sensitivity were compared between the two groups to guide precise treatment. The TIDE database was applied to predict the possibility of immune escape in the TCGA-HNSC cohort. Results Compared with normal samples, the expression of SLC25A17 was much higher in HNSCC tumor samples. For patients with high SLC25A17 expression, the OS and PFS were shorter than those with low SLC25A17 expression, indicating a worse prognosis. The expression of SLC25A17 varied in different clinical features. Univariate Cox and multivariate COX analyses showed that SLC25A17, age, and lymph node metastasis are independent prognostic risk factors for HNSCC, and the survival prediction model based on these factors had reliable predictive value. Patients in the low-expression group exhibited more immune cell infiltration, higher TME scores, higher IPS scores and lower TIDE scores than those in the high-expression groups, suggesting better immunotherapeutic response with lower SLC25A17 expression. Moreover, patients in the high-expression group were more sensitive to chemotherapy. Conclusions SLC25A17 can effectively predict the prognosis of HNSCC patients and could be a precise individual-targeted indicator for the treatment of HNSCC patients.

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Peroxisomal Membrane Protein PMP34 Is Involved in the Human Papillomavirus Infection Pathway

Cited by 2 publications

References 34 publications

The physiological functions of human peroxisomes

The physiological functions of human peroxisomes

Multiomics data analyses to identify SLC25A17 as a novel biomarker to predict the prognosis and immune microenvironment in head and neck squamous cell carcinoma

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