Peroxiredoxins in erythrocytes: far beyond the antioxidant role

de Paula, Carla Peres; de Oliveira da Silva, João Pedro Maia; Romanello, Karen Simone; Bernardo, Victoria Simões; Torres, Flaviene Felix; da Silva, Danilo Grünig Humberto; da Cunha, Anderson Ferreira

doi:10.1007/s00109-023-02368-7

Cited by 1 publication

(2 citation statements)

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“…It is reported that oxidative stress plays an important role in the pathogenesis of DKD. Wherein, PRDX family members are believed to play an important role in the process of oxidative stress 37 . Transcriptomic analysis of kidney tissue from DKD patients revealed that PRDX family members were not signi cantly upregulated or downregulated at the transcriptional level (Gene Expression Omnibus, GSE142025) 26 ; nevertheless, proteomic analysis of urine from DKD patients found that only PRDX1, 2, and 5 could be detected in urine, with the highest abundance of PRDX2, which was 2.6 times higher than that of DM patients (ProteomeXchange Datasets, PXD016571) 27 .…”

Section: Discussionmentioning

confidence: 99%

“…The role of the PRDX family members is diverse, and in addition to antioxidant activity, they can also function as a molecular chaperone, transduce peroxide signal, protect membranes from damage, and play a role in maintaining iron homeostasis 37 . A recent study found that PRDX2 participated in the cellular response to ROS and activated downstream signaling pathways through excessive oxidation by ROS within the cell.…”

Section: Discussionmentioning

confidence: 99%

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A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages

Li,

Long,

Peng

et al. 2024

Preprint

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Diabetic kidney disease (DKD) is the main cause of death due to diabetes mellitus (DM). Due to the complexity of the onset, it is difficult to achieve accurate prevention and treatment. The classically activated macrophages (M1) polarization is a crucial proinflammatory mechanism in DKD, while the interaction and cascade effects of oxidative stress and inflammatory response remain to be elucidated. A urine proteomic analysis of DM patients indicated that peroxiredoxin 2 (PRDX2) had the higher abundance in DKD. We recently found that PRDX of parasitic protozoa Entamoeba histolytica, which was similar to human PRDX2 in amino acid sequence and spatial structure, could activate the inflammatory response of macrophages through toll like receptor 4 (TLR4). Hence, our study was designed to explore the role of PRDX2 in chronic inflammation during DKD. Combined with in vivo and in vitro experiments, results showed that the PRDX2 was positively correlated with DKD progression and upregulated by high glucose or recombinant tumor necrosis factor-α in renal tubular epithelial cells; Besides, recombinant PRDX2 could promote macrophages M1 polarization, enhance the migration and phagocytic ability of macrophages through TLR4. In summary, our study has explored the novel role of PRDX2 in DKD to provide basis for further researches on the diagnosis and treatment of DKD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%