Peroxiredoxin, Senescence, and Cancer

Deng, Chujun; Lo, Tak-Ho; Chan, Ka-Ying; Li, Xiang; Wong, Chi‐Ming

doi:10.3390/cells11111772

Cited by 19 publications

(10 citation statements)

References 116 publications

(124 reference statements)

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“…Peroxiredoxin (Prdx) and glutathione reductase (GR) (P48642, Q8S5T1) were upregulated in Se-0:Se-6 expression. Prdx is a peroxidase that detoxifies peroxides, such as hydrogen peroxide, has broad substrate specificity and plays a key role in protecting cells from stress and maintaining homeostasis in many cellular processes [ 43 ]. The active action of Prdx is based on conserved Cys residues and depends on intermolecular or intramolecular mercaptan dioxide as an electron donor regeneration cycle, e.g., GSH and thioredoxin [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Lipid and Protein Oxidation of Brown Rice and Selenium-Rich Brown Rice during Storage

Zhang

Liu

2022

Foods

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Selenium-rich rice has become one of the effective ways to increase people’s selenium intake. Selenium-containing proteins have higher antioxidant properties, which may lead to selenium-rich brown rice (Se-BR) having better storage stability than ordinary brown rice (BR). By measuring the peroxidation value, fatty acid value, carbonyl value and protein secondary structure, it was found that Se-BR had higher oxidation resistance stability than BR. The biological function of the differential proteins (DEPs) between ordinary brown rice stored for 0 days (BR-0) and 180 days (BR-6) as well as Se-rich brown rice stored for 0 days (Se-0) and 180 days (Se-6) was investigated by using iTRAQ. A total of 237, 235, 113 and 213 DEPs were identified from group A (BR-0/BR-6), group B (Se-0/Se-6), group C (BR-0/Se-0) and group D (BR-6/Se-6), respectively. Kyoto Encyclopedia of Genes and Genomes analysis showed that the DEPs were mainly enriched in glucose metabolism, tricarboxylic acid cycle, fatty acid biosynthesis and degradation, glutathione metabolism, sulfur metabolism, peroxisome and other metabolic pathways. This study provides theoretical support for the study of protein oxidation kinetics and storage quality control of brown rice during storage.

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Section: Resultsmentioning

confidence: 99%

Lipid and Protein Oxidation of Brown Rice and Selenium-Rich Brown Rice during Storage

Zhang

Liu

2022

Foods

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“…This process also causes the removal of these damaged cells by activating the immune system through the SASP, but if the cells evade this fate, it may lead to tumorigenesis [ 34 ]. Emerging evidence showed that several ARGs may be the cause of onset and advancement of cancers due to regulation of the process of aging and cellular senescence by these ARGs and could be used as a target for cancer therapy [ 35 , 36 ]. Consequently, to analyze the exact role that aging plays in osteosarcoma, the transcriptome of the ARGs needs to be investigated thoroughly.…”

Section: Discussionmentioning

confidence: 99%

Identification and Development of an Age-Related Classification and Signature to Predict Prognosis and Immune Landscape in Osteosarcoma

Hong

et al. 2022

Journal of Oncology

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Background. In childhood and adolescence, the prevailing bone tumor is osteosarcoma associated with frequent recurrence and lung metastasis. This research focused on predicting the survival and immune landscape of osteosarcoma by developing a prognostic signature and establishing aging-related genes (ARGs) subtypes. Methods. The training group comprised of the transcriptomic and associated clinical data of 84 patients with osteosarcoma accessed at the TARGET database and the validation group consisted of 53 patients from GSE21257. The aging-related subtypes were identified using unsupervised consensus clustering analysis. The ARG signature was developed utilizing multivariate Cox analysis and LASSO regression. The prognostic value was assessed using the univariate and multivariate Cox analyses, Kaplan-Meier plotter, time-dependent ROC curve, and nomogram. The functional enrichment analyses were performed by GSEA, GO, and KEGG analysis, while the ssGSEA, ESTIMATE, and CIBERSORT analyses were conducted to reveal the immune landscape in osteosarcoma. Results. The two clusters of osteosarcoma patients formed based on 543 ARGs, depicted a considerable difference in the tumor microenvironment, and the overall survival and immune cell infiltration rate varied as well. Among these, the selected 23 ARGs were utilized for the construction of an efficient predictive prognostic signature for the overall survival prediction. The testing in the validation group of osteosarcoma patients confirmed the status of the high-risk score as an independent indicator for poor prognosis, which was already identified as such using the univariate and multivariate Cox analyses. Furthermore, the ARG signature could distinguish different immune-related functions, infiltration status of immune cells, and tumor microenvironment, as well as predict the immunotherapy response of osteosarcoma patients. Conclusion. The aging-related subtypes were identified and a prognostic signature was developed in this research, which determined different prognoses and allowed for treatment of osteosarcoma patients to be tailored. Additionally, the immunotherapeutic response of individuals with osteosarcoma could also be predicted by the ARG signature.

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“…Finally, Trx also contributes to peroxiredoxins (Prxs) by modulating the redox status and functions as an important mediator of redox signaling [ 128 , 129 ]. Reduced Trx can transfer reducing equivalents to the oxidized form of Prxs, and reduced Prx in turn scavenges ROS, e.g., H 2 O 2 [ 130 ].…”

Section: Trx/trxr Functions In Health and Diseasementioning

confidence: 99%

The Thioredoxin System of Mammalian Cells and Its Modulators

Hasan

Tatarskiy

Shtil³

2022

Biomedicines

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Oxidative stress involves the increased production and accumulation of free radicals, peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS), which are produced as by-products of aerobic respiration. ROS play a significant role in cell homeostasis through redox signaling and are capable of eliciting damage to macromolecules. Multiple antioxidant defense systems have evolved to prevent dangerous ROS accumulation in the body, with the glutathione and thioredoxin/thioredoxin reductase (Trx/TrxR) systems being the most important. The Trx/TrxR system has been used as a target to treat cancer through the thiol–disulfide exchange reaction mechanism that results in the reduction of a wide range of target proteins and the generation of oxidized Trx. The TrxR maintains reduced Trx levels using NADPH as a co-substrate; therefore, the system efficiently maintains cell homeostasis. Being a master regulator of oxidation–reduction processes, the Trx-dependent system is associated with cell proliferation and survival. Herein, we review the structure and catalytic properties of the Trx/TrxR system, its role in cellular signaling in connection with other redox systems, and the factors that modulate the Trx system.

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Peroxiredoxin, Senescence, and Cancer

Cited by 19 publications

References 116 publications

Lipid and Protein Oxidation of Brown Rice and Selenium-Rich Brown Rice during Storage

Lipid and Protein Oxidation of Brown Rice and Selenium-Rich Brown Rice during Storage

Identification and Development of an Age-Related Classification and Signature to Predict Prognosis and Immune Landscape in Osteosarcoma

The Thioredoxin System of Mammalian Cells and Its Modulators

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