Abstract:The nuclear protein HMGB1 (high mobility group box 1) is secreted by monocytesmacrophages in response to inflammatory stimuli and serves as a danger-associated molecular pattern. Acetylation and phosphorylation of HMGB1 are implicated in the regulation of its nucleocytoplasmic translocation for secretion, although inflammatory stimuli are also known to induce H 2 O 2 production. Here we show that H 2 O 2 -induced oxidation of HMGB1 that results in formation of an intramolecular disulphide bond between Cys 23 a… Show more
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