Peroxidase-Mimicking Nanozyme with Surface-Dispersed Pt Atoms as the Label for the Lateral Flow Immunoassay of C-Reactive Protein

Panferov, Vasily G.; Byzova, Nadezhda A.; Zherdev, Anatoly V.; Dzantiev, Boris B.

doi:10.26434/chemrxiv.14171249

Cited by 1 publication

(1 citation statement)

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“…Recent research has focused on introducing nanozymes as the detection labels for signal development, with the goal of improving assay perfor-mance and sensitivity. [49][50][51][52] We previously reported an ultrasensitive LFIA for the detection of p24, which is one of the earliest presenting HIV biomarkers, using a porous platinum coreshell structure (Figure 4A). [37] In this immunoassay, antibodyfunctionalized platinum nanocatalysts (PtNCs) displaying high internal surface area owing to an urchin-like morphology served as the detection probe.…”

Section: Nanozymes In Point-of-care Devicesmentioning

confidence: 99%

The Nanozyme Revolution: Enhancing the Performance of Medical Biosensing Platforms

et al. 2023

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Nanozymes represent a class of nanosized materials that exhibit innate catalytic properties similar to biological enzymes. The unique features of these materials have positioned them as promising candidates for applications in clinical sensing devices, specifically those employed at the point‐of‐care. They notably have found use as a means to amplify signals in nanosensor‐based platforms and thereby improve sensor detection limits. Recent developments in the understanding of the fundamental chemistries underpinning these materials have enabled the development of highly effective nanozymes capable of sensing clinically relevant biomarkers at detection limits that compete with “gold‐standard” techniques. However, there remain considerable hurdles that need to be overcome before these nanozyme‐based sensors can be utilized in a platform ready for clinical use. An overview of the current understandings of nanozymes for disease diagnostics and biosensing applications and the unmet challenges that must be considered prior to their translation in clinical diagnostic tests is provided.

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