Peroxidase-Mimicking DNAzymes as Receptors for Label-Free Discriminating Heavy Metal Ions by Chemiluminescence Sensor Arrays

Wu, Mengmeng; Yang, Bing; Shi, Lu; Tang, Qiaorong; Wang, Jing; Liu, Wei; Li, Baoxin; Jin, Yan

doi:10.1021/acs.analchem.2c05447

Cited by 14 publications

(58 citation statements)

References 39 publications

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“…The triple-emitting MOF was prepared by incorporating Eu 3+ and HCAA into the framework of a UiO-66-type MOF with free carboxylic acids (i.e., UiO-66 (10)). UiO-66 (10) was synthesized by replacing the usual ligand of UiO-66 (i.e., terephthalic acid, TPA) by trace amount of isophthalic acid (IPA, 10%), using the solvothermal method with a slight modification to the literature. 32,33 Next, Eu 3+ was loaded into UiO-66(10) via a coordination reaction, and the resulted material was denoted as Eu 3+ @UiO-66 (10).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…UiO-66 (10) was synthesized by replacing the usual ligand of UiO-66 (i.e., terephthalic acid, TPA) by trace amount of isophthalic acid (IPA, 10%), using the solvothermal method with a slight modification to the literature. 32,33 Next, Eu 3+ was loaded into UiO-66(10) via a coordination reaction, and the resulted material was denoted as Eu 3+ @UiO-66 (10). Finally, HCAA was introduced into Eu 3+ @UiO-66(10) by the impregnation method, obtaining the triple-emitting MOF, HCAA/Eu 3+ @ UiO-66 (10).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…32,33 Next, Eu 3+ was loaded into UiO-66(10) via a coordination reaction, and the resulted material was denoted as Eu 3+ @UiO-66 (10). Finally, HCAA was introduced into Eu 3+ @UiO-66(10) by the impregnation method, obtaining the triple-emitting MOF, HCAA/Eu 3+ @ UiO-66 (10). The MOFs were then characterized using various techniques, including scanning electron microscopy (SEM), Xray diffraction (XRD), nitrogen adsorption/desorption measurements, X-ray photoelectron spectroscopy (XPS), inductively coupled plasma-optical emission spectrometry (ICP-OES), thermogravimetric analysis (TG), and Raman, ultraviolet−visible (UV−vis) absorption, fluorescence, and extended X-ray absorption fine structure/near edge structure (EXAFS/XANES) spectroscopies.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…To discriminate five NACs, 50 μL of HCAA/Eu 3+ @UiO-66(10) solution (10 μg/ mL in 10 mM NaAc−HAc buffer, pH 5.0) was separately Scheme 1. Schematic Illustration of the (a) Design and (b) Fluorescence Screening and Discrimination Mechanisms of the HCAA/Eu 3+ @UiO-66 (10) pipetted into a 6 × 5 area in a 96-well plate, which contained 6 columns (a blank and 5 NACs) and 5 rows (5 replicates).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Multiple-Emitting Luminescent Metal–Organic Framework as an Array-on-a-MOF for Rapid Screening and Discrimination of Nitroaromatics

Chen,

Mo,

et al. 2024

Anal. Chem.

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Fluorescence array technologies have attracted great interest in the sensing field because of their high sensitivity, low cost, and capability of multitarget detection. However, traditional array sensing relies on multiple independent sensors and thus often requires time-consuming and laborious measurement processes. Herein, we introduce a novel fluorescence array strategy of the array-on-a-metal−organic framework (MOF), which integrates multiple array elements into a single MOF matrix to achieve facile sensing and discrimination of multiple target analytes. As a proofof-concept system, we constructed a luminescent MOF containing three different emitting channels, including a lanthanide ion (europium/Eu 3+ , red emission), a fluorescent dye (7-hydroxycoumarin-4-acetic acid/HCAA, blue emission), and the MOF itself (UiO-66-type MOF, blue-violet emission). Five structurally similar nitroaromatic compounds (NACs) were chosen as the targets. All three channels of the array-on-a-MOF displayed rapid and stable fluorescence quenching responses to NACs (response equilibrium achieved within 30 s). Different responses were generated for each channel against each NAC due to the various quenching mechanisms, including photoinduced electron transfer, energy competition, and the inner filter effect. Using linear discriminant analysis, the array-on-a-MOF successfully distinguished the five NACs and their mixtures at varying concentrations and demonstrated good sensitivity to quantify individual NACs (detect limit below the advisory concentration in drinking water). Moreover, the array also showed feasibility in the sensing and discrimination of multiple NACs in real water samples. The proposed "array-on-a-MOF" strategy simplifies multitarget discrimination procedures and holds great promise for various sensing applications.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Multiple-Emitting Luminescent Metal–Organic Framework as an Array-on-a-MOF for Rapid Screening and Discrimination of Nitroaromatics

Chen,

Mo,

et al. 2024

Anal. Chem.

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“…Combined with the mathematics analysis technique, such as a principal component analysis (PCA), linear discriminant analysis, and hierarchical clustering analysis (HCA), , the characteristic fingerprints can be transformed into simple visualization modes, enabling discrimination among different target analytes. Thus, many sensor arrays have been developed to detect and differentiate a wide range of analytes, including ions, proteins, DNA, and even small molecules with a similar structure or chemical characteristics . Though widely used for the recognition of various target analytes, there is still no report on sensor arrays for the detection and identification of His and its metabolites.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescence–Electrochemiluminescence Dual-Mode Sensor Arrays for Histidine and Its Metabolite Discrimination and Disease Identification

Qian,

Liu,

Huo

et al. 2023

Anal. Chem.

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Histidine (His) and its metabolite analysis is significant due to their vital roles in the diagnosis of diseases. In practical applications, simple and effective detection and discrimination of these metabolic species are still a great challenge due to their highly similar structures. Herein, photoluminescence (PL)−electrochemiluminescence (ECL) dual-mode sensor arrays consisting of a series of sensing elements were proposed for simultaneous quantitation and accurate discrimination of His and its four key metabolites (including histamine, imidazole-4-acetic acid, N-acetylhistamine, and imidazole propionate). The sensing elements of these sensor arrays were constructed by employing two solvent iridium(III) complexes ([Ir(pbz) 2 (DMSO)Cl] and [Ir-(ppy) 2 (DMSO)Cl], pbz = 3-(2-pyridyl)benzoic acid, ppy = 2phenylpyridine) with excellent PL and ECL performances as cross-responsive sensing units. Based on diverse coordination abilities of the two complexes with the imidazole group of the five targets, PL and ECL responses of each sensing unit can be enhanced to various degrees, which generate unique fingerprint patterns for the corresponding targets. Through principal component analysis, the multifarious patterns (two-, three-, and four-element sensor arrays) can be transformed into simple visualization modes, from which His and its four key metabolites can be effectively discriminated against each other. Moreover, the quantitation of an individual metabolic species at different concentrations and the recognition of the mixtures with different ratios were also accurately achieved. Notably, His and its four key metabolites in urine can also be successfully discriminated by the as-fabricated sensor arrays, and the patients with kidney diseases can be identified clearly, providing a promising way for disease diagnosis.

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Facile one-pot synthesis of triethanolamine-functionalized AuNPs-GO-UiO-66-NH2 nanocomposites for simultaneous electrochemical detection of Cd(II), Pb(II), and Cu(II)

Tu,

Li,

Liu

et al. 2023

J Solid State Electrochem

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Peroxidase-Mimicking DNAzymes as Receptors for Label-Free Discriminating Heavy Metal Ions by Chemiluminescence Sensor Arrays

Cited by 14 publications

References 39 publications

Multiple-Emitting Luminescent Metal–Organic Framework as an Array-on-a-MOF for Rapid Screening and Discrimination of Nitroaromatics

Multiple-Emitting Luminescent Metal–Organic Framework as an Array-on-a-MOF for Rapid Screening and Discrimination of Nitroaromatics

Photoluminescence–Electrochemiluminescence Dual-Mode Sensor Arrays for Histidine and Its Metabolite Discrimination and Disease Identification

Facile one-pot synthesis of triethanolamine-functionalized AuNPs-GO-UiO-66-NH2 nanocomposites for simultaneous electrochemical detection of Cd(II), Pb(II), and Cu(II)

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