Peroxidase-like behavior and photothermal effect of chitosan-coated Prussian-blue nanoparticles: dual-modality antibacterial action with enhanced bioaffinity

Chakraborty, Nayanika; Jha, Diksha; Gautam, Hemant K.; Roy, Indrajit

doi:10.1039/d0ma00231c

Cited by 15 publications

(11 citation statements)

References 49 publications

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“…75 The above discussed heteroatoms have their own unique properties, but out of all of these, nitrogen is best because of its half shell electronic configuration and presence of a lone pair. 23,[76][77][78][79][80][81][82] The comparable atomic size of nitrogen and carbon makes it highly suitable for doping in the carbon framework. 83 These lone pairs act as electron donor sites, which make them an active site for substrate catalysis and provide a path with low activation energy.…”

Section: Effect Of Heteroatom Incorporationmentioning

confidence: 99%

Prospects of nano-carbons as emerging catalysts for enzyme-mimetic applications

et al. 2022

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Section: Effect Of Heteroatom Incorporationmentioning

confidence: 99%

Prospects of nano-carbons as emerging catalysts for enzyme-mimetic applications

et al. 2022

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“…However, as PB nanocrystals generate heating upon exposure to visible light, their antibacterial activity can be significantly enhanced upon combined photothermal therapy. We have demonstrated that the antibacterial action of the PB nanocrystal platform can be further enhanced upon coating with a layer of chitosan that facilitates high affinity electrostatic interaction with both Gram-positive and Gram-negative bacterial cells [ 52 ]. In a separate work, we have shown that upon doping silver ions in the PB network, very high broad-spectrum antibacterial action could be observed due to the combined effects of ROS generation and silver-ion-mediated toxicity, along with a photothermal effect [ 53 ].…”

Section: Nanozyme Platforms For Antibacterial Applicationsmentioning

confidence: 99%

“…For example, since iron-oxide-based nanoparticles have already been used as clinical MR contrast agents, iron-oxide -based nanozymes can be considered as promising candidates in this regard. On the other hand, Prussian blue (PB) nanoparticles are used clinically for the removal of radioactive contaminants in humans [ 52 , 53 ]; thus, PB-based nanozymes can also be explored for advanced clinical aspects. Other nanozymes based on biocompatible nanoparticles, such as graphene oxide, metal–organic frameworks, single-atom nanozymes, etc., are also being extensively explored in this regard.…”

Section: Challenges and Opportunities Of Nanozymesmentioning

confidence: 99%

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

et al. 2022

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The ability of some nanoparticles to mimic the activity of certain enzymes paves the way for several attractive biomedical applications which bolster the already impressive arsenal of nanomaterials to combat deadly diseases. A key feature of such ‘nanozymes’ is the duplication of activities of enzymes or classes of enzymes, such as catalase, superoxide dismutase, oxidase, and peroxidase which are known to modulate the oxidative balance of treated cells for facilitating a particular biological process such as cellular apoptosis. Several nanoparticles that include those of metals, metal oxides/sulfides, metal–organic frameworks, carbon-based materials, etc., have shown the ability to behave as one or more of such enzymes. As compared to natural enzymes, these artificial nanozymes are safer, less expensive, and more stable. Moreover, their catalytic activity can be tuned by changing their size, shape, surface properties, etc. In addition, they can also be engineered to demonstrate additional features, such as photoactivated hyperthermia, or be loaded with active agents for multimodal action. Several researchers have explored the nanozyme-mediated oxidative modulation for therapeutic purposes, often in combination with other diagnostic and/or therapeutic modalities, using a single probe. It has been observed that such synergistic action can effectively by-pass the various defense mechanisms adapted by rogue cells such as hypoxia, evasion of immuno-recognition, drug-rejection, etc. The emerging prospects of using several such nanoparticle platforms for the treatment of bacterial infections/diseases and cancer, along with various related challenges and opportunities, are discussed in this review.

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“…Roy and colleagues have found that the well-known pigment Prussian Blue (PB), and its analogues (PBAs) can serve as efficient nanoparticulate photothermal agents [200]. They have demonstrated efficient bactericidal and anticancer action using a formulation of chitosan-coated PB nanoparticles irradiated with red-emitting laser light [201]. Recently, it has been recognized that localized PTT also triggers a systemic immunogenic response that affects cancer cells in non-target regions (abscopal effect) [192,202].…”

Section: Photothermal Therapymentioning

confidence: 99%

Aberrant Signaling Pathways in Cancer Cells: Application of Nanomaterials

2021

Journal of Cellular Signaling

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Cell signaling pathways involve several proteins, called kinases, to pass on vital messages from the transmembrane-proteins, e.g., receptor tyrosine kinases (RTKs) to the nucleus of a cell through a cascade of processes for various activities such as controlled cell division, proliferation, apoptosis, metabolism, DNA replication and repair. Alterations in these signaling proteins combined with genetic and/or epigenetic mutations spawn various types of cancer that empowers the cells to ignore or maneuver the immune signals and carry on felonious activities such as uncontrolled cell division and growth, genetic instability, angiogenesis around the tumor in hypoxia, eluding the body's immune system, cell migration, and invasion of surrounding healthy cells. Inhibition of such malicious transmuted signaling pathways has therapeutic importance for cancer. In this article, we have briefly described three vital signaling pathways that are aberrantly triggered by Ras and Wnt proteins and the NF-2 genes causing different types of cancer. Recent research in the targeted therapy using drugs to put off these signaling pathways, especially, for cancer stem cells (CSCs) has been reviewed here. However, such therapy suffers a low success rate due to the resistance to drugs by cancer cells. Considering this snag of targeting drugs, many researchers use nanoparticles for this purpose; some of these works have been reviewed in brief. The consequences of protein-nanoparticles interaction in this approach has also been discussed. Finally, we have proposed use of nanomaterials for targeted ion delivery, or targeted heating using light or magnetic field, to destroy cancer cells.

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Peroxidase-like behavior and photothermal effect of chitosan-coated Prussian-blue nanoparticles: dual-modality antibacterial action with enhanced bioaffinity

Abstract: Mechanism of peroxidase-like activity and photothermal effect of chitosan-coated Prussian blue nanoparticles.

Cited by 15 publications

References 49 publications

Prospects of nano-carbons as emerging catalysts for enzyme-mimetic applications

Prospects of nano-carbons as emerging catalysts for enzyme-mimetic applications

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

Aberrant Signaling Pathways in Cancer Cells: Application of Nanomaterials

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