Peroxidase-encapsulated Zn/Co-zeolite imidazole framework nanosheets on ZnCoO nanowire array for detecting H2O2 derived from mitochondrial superoxide anion

Jin, Xin; Geng, Chaoyao; Zhao, Dan; Liu, Yuan; Wang, Xingqi; Liu, Xiaoqiang; Wong, Danny K.Y.

doi:10.1016/j.bios.2023.115547

Cited by 10 publications

(1 citation statement)

References 33 publications

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“…Jin et al [100] developed a nanocomposite designated as 2D-Zn/Co-ZIF(HRP)|ZnCoO, which consisted of horseradish peroxidase (HRP)-encapsulated 2D Zn-Co ZIF nanosheets strung on a ZnCoO nanowire array on a Ti substrate (Figure 5A). This EC biosensor had the potential to detect H 2 O 2 produced by O 2…”

Section: Ec Detection Of Mitochondrial Rosmentioning

confidence: 99%

Recent Advances in Electrochemical Detection of Cell Energy Metabolism

Koo,

Kim,

Kim

2024

Biosensors

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Cell energy metabolism is a complex and multifaceted process by which some of the most important nutrients, particularly glucose and other sugars, are transformed into energy. This complexity is a result of dynamic interactions between multiple components, including ions, metabolic intermediates, and products that arise from biochemical reactions, such as glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), the two main metabolic pathways that provide adenosine triphosphate (ATP), the main source of chemical energy driving various physiological activities. Impaired cell energy metabolism and perturbations or dysfunctions in associated metabolites are frequently implicated in numerous diseases, such as diabetes, cancer, and neurodegenerative and cardiovascular disorders. As a result, altered metabolites hold value as potential disease biomarkers. Electrochemical biosensors are attractive devices for the early diagnosis of many diseases and disorders based on biomarkers due to their advantages of efficiency, simplicity, low cost, high sensitivity, and high selectivity in the detection of anomalies in cellular energy metabolism, including key metabolites involved in glycolysis and mitochondrial processes, such as glucose, lactate, nicotinamide adenine dinucleotide (NADH), reactive oxygen species (ROS), glutamate, and ATP, both in vivo and in vitro. This paper offers a detailed examination of electrochemical biosensors for the detection of glycolytic and mitochondrial metabolites, along with their many applications in cell chips and wearable sensors.

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Section: Ec Detection Of Mitochondrial Rosmentioning

confidence: 99%

Recent Advances in Electrochemical Detection of Cell Energy Metabolism

Koo,

Kim,

Kim

2024

Biosensors

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Tunable Structured 2D Nanobiocatalysts: Synthesis, Catalytic Properties and New Horizons in Biomedical Applications

Cui,

Gao,

Wen

et al. 2024

Small

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Abstract2D materials have offered essential contributions to boosting biocatalytic efficiency in diverse biomedical applications due to the intrinsic enzyme‐mimetic activity and massive specific surface area for loading metal catalytic centers. Since the difficulty of high‐quality synthesis, the varied structure, and the tough choice of efficient surface loading sites with catalytic properties, the artificial building of 2D nanobiocatalysts still faces great challenges. Here, in this review, a timely and comprehensive summarization of the latest progress and future trends in the design and biotherapeutic applications of 2D nanobiocatalysts is provided, which is essential for their development. First, an overview of the synthesis‐structure‐fundamentals and structure‐property relationships of 2D nanobiocatalysts, both metal‐free and metal‐based is provided. After that, the effective design of the active sites of nanobiocatalysts is discussed. Then, the progress of their applied research in recent years, including biomedical analysis, biomedical therapeutics, pharmacokinetics, and toxicology is systematically highlighted. Finally, future research directions of 2D nanobiocatalysts are prospected. Overall, this review to provide cutting‐edge and multidisciplinary guidance for accelerating future developments and biomedical applications of 2D nanobiocatalysts is expected.

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Pyridine‐Bridged Covalent Organic Frameworks with Adjustable Band Gaps as Intelligent Artificial Enzymes for Light‐Augmented Biocatalytic Sensing

Cui,

Zhou,

Wen

et al. 2024

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One of the biggest challenges in biotechnology and medical diagnostics is finding extremely sensitive and adaptable biosensors. Since metal‐based enzyme‐mimetic biocatalysts may lead to biosafety concerns on accumulative toxicity, it is essential to synthesize metal‐free enzyme‐mimics with optimal biocatalytic activity and superior selectivity. Here, the pyridine‐bridged covalent organic frameworks (COFs) with specific oxidase‐like (OXD‐like) activities as intelligent artificial enzymes for light‐augmented biocatalytic sensing of biomarkers are disclosed. Because of the adjustable bandgaps of pyridine structures on the photocatalytic properties of the pristine COF structures, the pyridine‐bridged COF exhibit efficient, selective, and light‐responsive OXD‐like biocatalytic activity. Moreover, the pyridine‐bridged COF structures show tunable and light‐augmented biocatalytic detection capabilities, which outperform the recently reported state‐of‐the‐art OXD‐mimics regarding biosensing efficiency. Notably, the pyridine‐bridged COF exhibits efficient and multifaceted diagnostic activity, including the extremely low limit of detection (LOD), which enables visual assays for abundant reducibility biomarkers. It is believed that this design will offer unique metal‐free biocatalysts for high‐sensitive and low‐cost colorimetric detection and also provide new insights to create highly efficient enzyme‐like COF materials via linkage‐modulation strategies for future biocatalytic applications.

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Peroxidase-encapsulated Zn/Co-zeolite imidazole framework nanosheets on ZnCoO nanowire array for detecting H2O2 derived from mitochondrial superoxide anion

Cited by 10 publications

References 33 publications

Recent Advances in Electrochemical Detection of Cell Energy Metabolism

Recent Advances in Electrochemical Detection of Cell Energy Metabolism

Tunable Structured 2D Nanobiocatalysts: Synthesis, Catalytic Properties and New Horizons in Biomedical Applications

Pyridine‐Bridged Covalent Organic Frameworks with Adjustable Band Gaps as Intelligent Artificial Enzymes for Light‐Augmented Biocatalytic Sensing

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