Perovskite Mediated Vibronic Coupling of Semiconducting SERS for Biosensing

Abstract

Improving charge transfer efficiency via vibronic coupling is vital to the performance of semiconducting surface-enhanced Raman spectroscopy (SERS). Previous attempts have focused on defects-based metastable-state assisted band structure matching strategy to enhance vibronic coupling. However, defect-related charge transfer transitions can be easily deteriorated due to enhanced phonon-assisted relaxation upon continuous laser irradiation. Herein, perovskite-based steady-state assisted band structure matching strategy is proposed to enhance vibronic coupling within perovskite-molecule charge transfer complex, leading to remarkable Raman enhancement up to 5.9 × 10 6 . Particularly, vibronic coupling can be modulated by tuning valence band position and introducing ultrathin Au coating, which allows selective enhancement of molecules with different band structures, including narrowbandgap molecules and wide-bandgap molecules. Importantly, based on intrinsically stable conduction band and valence band states, this system achieves ultrahigh photostability, preserving 91.3% of the original intensity after 50 000 s of irradiation. This system also provides an outstanding tool for trace molecular detection, allowing sensitive and selective identification of 9 types of gastric cancer related aldehydes, which enables distinguishing the breath of gastric cancer patients from healthy controls with a discriminatory accuracy of 81.09%. This study is anticipated to shed new light into the future strategy design of efficient and stable semiconducting SERS.

Application of SERS in In‐Vitro Biomedical Detection

“…How to selectively detect other molecules without affinity is still a problem to be considered. In addition, charge transfer causes shifts of the analyte's inherent vibration fingerprint, which leads to peak broadening and increases the difficulty of accurate interpretation [32] …”

“…In addition, charge transfer causes shifts of the analyte's inherent vibration fingerprint, which leads to peak broadening and increases the difficulty of accurate interpretation. [32] MXene is a typical inorganic lamellar material, MXene is composed of transition metal carbides/nitrides with several atomic layers. As a two-dimensional material, it has been widely studied in supercapacitors, batteries, sensors, medicine and other fields due to its unique hydrophilicity, biocompatibility and conductivity.…”

Charge‐Transfer Polymeric Hydrogels with Self‐Healing, Injectable, Thermosensitive, Adhesive, and Antibacterial Properties for Diabetic Wound Healing

“…[ 3 ] Numerous CT complexes are formed by CT interactions and have been studied for a long time. [ 4 ] Plenty of attractive characteristics, including photothermal therapy, [ 5 ] biomedical imaging, [ 6 ] biosensing, [ 7 ] antibacteria, [ 8 ] reversible assembly, [ 9,10 ] and wound healing, [ 11 ] have been reported from the studies of CT complexes. Bulk materials containing CT complexes can inherit their characteristics.…”

Tunable Preparation of SERS-Active Au–Ag Janus@Au NPs for Label-Free Staphylococcal Enterotoxin C Detection

“…In contrast, surface-enhanced Raman scattering (SERS) analysis is simple to operate, takes less time to detect, and does not require complex pre-treatment of samples, so it can greatly improve the detection efficiency and shows potential application for SEC detection. − Noble metal nanomaterials have been widely applied in SERS research because of their strong localized surface plasmon resonance (LSPR). ,− LSPR can cause localized electromagnetic (EM) field enhancement, and the EM field enhancement effect is one of the two widely accepted theoretical mechanisms for SERS enhancement . Most SERS sensors rely on the Raman signal of the target itself for quantitative detection or require additional modification of the Raman reporter on the plasmonic nanoprobes to obtain the strong detection signal. − These will lead to the following limitations: (1) The targets without an inherent Raman signal or with low Raman intensity cannot be sensitively detected. (2) The additional modification of Raman reporters may induce unstable SERS signals and are susceptible to the surrounding complex sample matrices.…”