Peroral Cholangioscopy-Guided Forceps Biopsy and Endoscopic Scraper for the Diagnosis of Indeterminate Extrahepatic Biliary Stricture

Kato, Masayuki; Onoyama, Takumi; Takeda, Yohei; Kawata, Soichiro; Kurumi, Hiroki; Koda, Hiroki; Yamashita, Taro; Hamamoto, Wataru; Sakamoto, Yuri; Matsumoto, Kazuya; Isomoto, Hajime

doi:10.3390/jcm8060873

Cited by 9 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies reported that the use of POCS can improve the diagnostic accuracy of indeterminate biliary lesions (6,12). On the other hands, the sensitivities of POCS-guided forceps biopsy for malignant biliary stricture (60.1%) and cholangiocarcinoma (66.2%) were still insufficient (8) and were similar for fluoroscopic tissue acquisition (7,15). Moreover, the sensitivity and accuracy of POCSguided forceps biopsy for indeterminate biliary lesions were lower than those of visual findings for POCS in past study (13).…”

Section: Discussionmentioning

confidence: 99%

Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy

Onoyama¹,

Takeda²,

Kawata³

et al. 2020

Ann Transl Med

Self Cite

View full text Add to dashboard Cite

Background: Peroral cholangioscopy (POCS)-guided forceps biopsy is a method for diagnosing indeterminate biliary strictures and for the preoperative identification of the exact perihilar and distal margins of biliary tract cancer (BTC). However, POCS-guided forceps biopsy may result in an insufficient amount of specimen at times. Therefore, we evaluated the adequate tissue acquisition rate and the factors affecting the adequate tissue acquisition of POCS-guided forceps biopsy for the biliary tract.Methods: Patients who underwent POCS-guided forceps biopsy for biliary disease between September 2016 and October 2018 at our hospital were enrolled retrospectively. We evaluated the adequate tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion and that for non-stenotic bile duct.In addition, the factors affecting the adequate tissue acquisition rate of POCS-guided forceps biopsy were evaluated.Results: We enrolled 47 patients with biliary disease and performed POCS-guided forceps biopsy for biliary lesion and POCS-guided forceps mapping biopsy for non-stenotic bile duct in 40 and 36 patients, respectively. The adequate tissue acquisition rates of POCS-guided forceps biopsy for biliary lesions and that for non-stenotic bile duct were 86.4%, and 68.9%, respectively. In the multivariate logistic regression analyses, age, and previous biliary stenting before POCS were factors affecting the adequate tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion. For non-stenotic bile duct, the location of the biliary lesion, endoscopic sphincterotomy (EST), and procedure time of POCS were factors affecting the adequate tissue acquisition rate of POCS-guided forceps mapping biopsy.Conclusions: Previous biliary stenting was a factor affecting a low tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion. In the POCS-guided forceps mapping biopsy, the location of the biliary lesion, EST, and procedure time were factors affecting tissue acquisition rates.

show abstract

Section: Discussionmentioning

confidence: 99%

Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy

Onoyama¹,

Takeda²,

Kawata³

et al. 2020

Ann Transl Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…An endoscopic scraper (Trefle; Piolax Medical Devices, Yokohama, Japan; Supplementary Figure S1 ) is now available [ 8 ] and has been used for the diagnosis of biliary strictures, mainly in Japan [ 9 , 10 ]. This device has unique configurations; the wire-guided system is designed to access biliary strictures over the guidewire, and three scraping loops are used specifically to obtain tissues and cell samples for histology and cytology.…”

Section: Introductionmentioning

confidence: 99%

Use of Endoscopic Scraper and Cell Block Technique as a Replacement for Conventional Brush for Diagnosing Malignant Biliary Strictures

Kato

Naitoh

Hayashi

et al. 2022

Cancers

View full text Add to dashboard Cite

Histological evidence is essential for diagnosing malignant biliary strictures. However, conventional brush cytology remains the primary method used worldwide, despite its low diagnostic sensitivity and accuracy, as it is technically easy, rapid, and cost-effective. The aim of this study was to evaluate the diagnostic performance of a recently introduced endoscopic scraper, the simplicity of which is comparable to that of a conventional brush, by comparing diagnostic yields and the number of collected cells. The sensitivity of the endoscopic scraper when using the cell block technique was significantly higher than when using brush cytology or a brush with the cell block technique (53.6% vs. 30.9%, p < 0.001; 53.6% vs. 31.6%, p = 0.024, respectively). Quantitative digital image analysis of cell block sections revealed that the median number of cells obtained with the endoscopic scraper was significantly higher than when using the brush (1917 vs. 1014 cells, p = 0.042). Furthermore, seven cases (8.3%; 7/84) were diagnosed by immunohistochemical analysis of the cell block section obtained from the endoscopic scraper. Given its simplicity and greater capacity for sample acquisition, use of the endoscopic scraper in conjunction with the cell block technique could replace brush cytology for the histological diagnosis of malignant biliary strictures.

show abstract

“…Some studies reported that the use of POCS can improve the diagnostic accuracy of indeterminate biliary lesions [6,12]. On the other hands, the sensitivities of POCS-guided forceps biopsy for malignant biliary stricture (60.1%) and cholangiocarcinoma (66.2%) were still insufficient [8] and were similar for fluoroscopic tissue acquisition [7,15]. Moreover, the sensitivity and accuracy of POCS-guided forceps biopsy for indeterminate biliary lesions were lower than those of visual findings for POCS in past study [13].…”

Section: Discussionmentioning

confidence: 99%

Sufficient Tissue Acquisition Rate of Peroral Cholangioscopy-guided Forceps Biopsy

Onoyama

Takeda

Kawata

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Peroral cholangioscopy (POCS)-guided forceps biopsy is a method for diagnosing indeterminate biliary strictures and for the preoperative identification of the exact perihilar and distal margins of biliary tract cancer (BTC). However, POCS-guided forceps biopsy may result in an insufficient amount of specimen at times. Aims: We evaluated the sufficient tissue acquisition rate and the factors affecting the sufficient tissue acquisition of POCS-guided forceps biopsy for the biliary tract. Methods: Patients who underwent POCS-guided forceps biopsy for biliary disease between September 2016 and October 2018 at our hospital were enrolled retrospectively. We evaluated the sufficient tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion and that for nonstenotic bile duct. In addition, the factors affecting the sufficient tissue acquisition rate of POCSguided forceps biopsy were evaluated. Results and Conclusions : We enrolled 47 patients with the biliary disease and performed POCS-guided forceps biopsy for biliary lesion and POCS-guided forceps mapping biopsy for non-stenotic bile duct in 40 and 36 patients, respectively. The sufficient tissue acquisition rates of POCS-guided forceps biopsy for biliary lesions and that for non-stenotic bile duct were 86.4%, and 68.9%, respectively. In the multivariate logistic regression analyses, age and previous biliary stenting before POCS were factors affecting the sufficient tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion. For non-stenotic bile duct, the location of the biliary lesion, endoscopic sphincterotomy, and procedure time of POCS were factors affecting the sufficient tissue acquisition rate of POCS-guided forceps mapping biopsy.

show abstract

Peroral Cholangioscopy-Guided Forceps Biopsy and Endoscopic Scraper for the Diagnosis of Indeterminate Extrahepatic Biliary Stricture

Cited by 9 publications

References 26 publications

Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy

Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy

Use of Endoscopic Scraper and Cell Block Technique as a Replacement for Conventional Brush for Diagnosing Malignant Biliary Strictures

Sufficient Tissue Acquisition Rate of Peroral Cholangioscopy-guided Forceps Biopsy

Contact Info

Product

Resources

About