Peroperative treatment with i.v. ketoprofen reduces pain and vomiting in children after strabismus surgery

Abstract

We concluded that ketoprofen administered i.v. during the operation produced analgesia and reduced opioid consumption and the incidence of vomiting in children after strabismus surgery.

Comparison of Acetaminophen and Ketoprofen in Febrile Children: A Single Dose Randomized Clinical Trial

“…Overdosing was more likely with ibuprofen both in dosage and frequency. No serious adverse events including gastric bleeding were reported in several clinical studies evaluating the efficacy of ketoprofen for longer durations in pain treatment in children [23][24][25]. In the present study only one patient had an allergy favoring urticaria in the ketoprofen group.…”

Subtenons lidocaine injection for postoperative pain relief after strabismus surgery in children: A prospective randomized controlled trial

“…4 The efficacy of a variety of opioid and nonsteroidal agents have been investigated in relation to strabismus surgery, [5][6][7][8][9] but postoperative pain remains a problem in some children.…”

Current management of pediatric postoperative pain

“…The incidence of nausea and vomiting with morphine, buprenorphine and tramadol (Ultram ® , Johnson & Johnson, PA, USA) is often reported to be high because up to 50% of children may develop emesis [61][62][63][64]. Nausea and vomiting may occur significantly less often with fentanyl and sufentanil (Sufenta ® , Wyeth-Ayerst Laboratories, PA, USA) [38,47,[65][66][67].…”

“…Morphine doses above 0.1 mg/kg are associated with a greater than 50% incidence of vomiting [61,63]. With fentanyl at doses of 2 µg/kg or less, vomiting occurs very rarely [38,65,66]. In contrast to dose-dependency, the risk of nausea and vomiting appears not to vary between different administration routes [64].…”