Pernicious anemia presenting as catatonia: correlating vitamin B12 levels and catatonic symptoms

Bram, Damien; Bubrovszky, Maxime; Durand, Jean-Paul; Lefèvre, Guillaume; Morell-Dubois, Sandrine; Vaïva, Guillaume

doi:10.1016/j.genhosppsych.2015.02.003

Cited by 14 publications

(9 citation statements)

References 10 publications

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“…Psychiatric symptoms can sometimes occur without hematological and neurological abnormalities and can be prodromal of vitamin B12 deficiency (16). Bram et al reported a case of autoimmune B12 deficiency presenting as catatonia without anemia or other abnormalities where a correlation was found between the patient's B12 blood levels and catatonic symptoms over time (17).…”

Section: Discussionmentioning

confidence: 99%

Catatonia Development in a Patient with Bipolar Disorder Following Electroconvulsive Therapy: A Case Report

Mashayekhi

Ghayoumi

2019

IJPS

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Objective: Electroconvulsive therapy (ECT) is a major treatment of catatonia; and catatonia development during electroconvulsive therapy is a highly surprising phenomenon. We present a patient with bipolar disorder who developed catatonia during ECT. Case Reports: A 21-year-old woman, with a known case of bipolar disorder in manic phase without psychotic feature, history of long acting antipsychotic use, and severe B12 deficiency, was treated with ECT. Full catatonia syndrome developed after the fifth session of ECT. Conclusion: In rare cases, catatonia can develop during ECT course in the presence of some precipitating factors. Thus, these precipitating factors should be eliminated as much as possible before the start of ECT course to prevent catatonia development.

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Section: Discussionmentioning

confidence: 99%

Catatonia Development in a Patient with Bipolar Disorder Following Electroconvulsive Therapy: A Case Report

Mashayekhi

Ghayoumi

2019

IJPS

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“…Identification depends on a high grade of suspicion, because it can even occur with normal B 12 levels 11. Psychiatric symptoms related to lack of cyanocobalamin are considered rare, but this has been reported as the only identifiable cause 11–13.…”

Section: Discussionmentioning

confidence: 99%

Catatonia as an internal medicine disease: infrequent or still underdiagnosed?

et al. 2016

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Catatonia is a motor and behavioural syndrome with multiple psychiatric, general medical and neurological aetiologies that might be simultaneously present. B12 deficiency is a rare, treatable cause of catatonia, not always easy to rule out. The authors present a case of a woman with catatonia associated with severe cyanocobalamin deficiency, admitted to an internal medicine ward. The benign course was related to an adequate and early diagnosis.

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“…Two cases of catatonia in pernicious anaemia have been reported, both of whom responded to vitamin B12 supplementation. 82,83 Dietary vitamin B12 deficiency might also cause catatonia. 84,85 In thyroid disease, catatonia has been reported in patients with thyroid autoantibodies with hyper thyroid, [86][87][88] hypothyroid, 90,91 and euthyroid 91,92 states.…”

Section: Autoimmune Disorders Causing Catatoniamentioning

confidence: 99%

Catatonia and the immune system: a review

Rogers

Pollak

Blackman

et al. 2019

The Lancet Psychiatry

146

119

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Catatonia is a psychomotor disorder featuring stupor, posturing, and echophenomena. This Series paper examines the evidence for immune dysregulation in catatonia. Activation of the innate immune system is associated with mutism, withdrawal, and psychomotor retardation, which constitute the neurovegetative features of catatonia. Evidence is sparse and conflicting for acute-phase activation in catatonia, and whether this feature is secondary to immobility is unclear. Various viral, bacterial, and parasitic infections have been associated with catatonia, but it is primarily linked to CNS infections. The most common cause of autoimmune catatonia is N-methyl-D-aspartate receptor (NMDAR) encephalitis, which can account for the full spectrum of catatonic features. Autoimmunity appears to cause catatonia less by systemic inflammation than by the downstream effects of specific actions on extracellular antigens. The specific association with NMDAR encephalitis supports a hypothesis of glutamatergic hypofunction in catatonia.

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Pernicious anemia presenting as catatonia: correlating vitamin B12 levels and catatonic symptoms

Cited by 14 publications

References 10 publications

Catatonia Development in a Patient with Bipolar Disorder Following Electroconvulsive Therapy: A Case Report

Catatonia Development in a Patient with Bipolar Disorder Following Electroconvulsive Therapy: A Case Report

Catatonia as an internal medicine disease: infrequent or still underdiagnosed?

Catatonia and the immune system: a review

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